Volume 21 Issue 2
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(2): 195-198
LI Jing, LI Xiao-feng, YAN Ni, LIU Ling-jiao. Evaluation the screening value of obesity-related indices for non-alcoholic fatty liver disease[J]. Chinese Journal of General Practice, 2023, 21(2): 195-198. doi: 10.16766/j.cnki.issn.1674-4152.002843
Citation: LI Jing, LI Xiao-feng, YAN Ni, LIU Ling-jiao. Evaluation the screening value of obesity-related indices for non-alcoholic fatty liver disease[J]. Chinese Journal of General Practice, 2023, 21(2): 195-198. doi: 10.16766/j.cnki.issn.1674-4152.002843
shu

Evaluation the screening value of obesity-related indices for non-alcoholic fatty liver disease

doi: 10.16766/j.cnki.issn.1674-4152.002843
  • 1.

    Department of Endocrinology, Shaanxi Provincial People' s Hospital, Xi' an, Shaanxi 710068, China

Funds:

 81700735

  • Received Date: 2022-07-13
    Available Online: 2023-04-20
    Abstract
  •   Objective  To explore obesity-related indices suitable for screening non-alcoholic fatty liver disease (NAFLD) in middle-aged and elderly population.  Methods  This cross-sectional study screened 1 281 people aged 40 and above who attended physical examinations at the Health Management Center of Shaanxi Provincial People' s Hospital from January to March 2019. Their medical history was recorded, and they underwent physical examination and laboratory tests. All subjects underwent abdominal ultrasonography. Logistic regression was used to analyse the association between obesity index and the risk of NAFLD. ROC curve was used to evaluate the screening value of obesity indices for the risk of NAFLD.  Results  Among 1 281 subjects, 335 were diagnosed with NAFLD, with a prevalence rate of 26.15%. The blood pressure, triglyceride, total cholesterol, low density lipoprotein cholesterol, transaminase levels, fasting blood glucose, fasting insulin, homeostasis model assessment of insulin resistance, haemoglobin A1c, waist circumference (WC), waist-to-hip ratio (WHR), BMI and lipid accumulation product (LAP) values significantly increased in the NAFLD group, and the high-density lipoprotein cholesterol decreased. Logistic regression analysis showed that WC, WHR, BMI and LAP were significantly correlated with NAFLD after adjusting for confounding factors. Among them, LAP had the strongest correlation with NAFLD. Compared with subjects in the first quartile of LAP, subjects in the fourth quartile had a significantly increased risk of NAFLD (OR=18.055, 95% CI: 7.683-42.427, P < 0.001). The AUC of the four obesity indices were all greater than 0.7, indicating that they had high screening value for NAFLD. LAP had the highest screening value for NAFLD in males and females, with AUC 85.34 (95% CI: 81.78-88.90) in males and AUC 80.22 (95% CI: 76.95-83.48) in females.  Conclusion  LAP is closely associated with the risk of NAFLD and may be an effective tool for screening the disease in middle-aged and elderly people.

     

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