Volume 21 Issue 3
Mar.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(3): 361-364
ZHANG Mengmeng, TANG Huili, HUANG He, CAI Jingxing, WU Xiaoying, YANG Chuanzhong, YU Zhangbin, LI Sitao, ZHOU Xiaoguang. Analysis of the critical values of partial coagulation function indicators in 1 057 neonates in the early stages of life[J]. Chinese Journal of General Practice, 2023, 21(3): 361-364. doi: 10.16766/j.cnki.issn.1674-4152.002883
Citation: ZHANG Mengmeng, TANG Huili, HUANG He, CAI Jingxing, WU Xiaoying, YANG Chuanzhong, YU Zhangbin, LI Sitao, ZHOU Xiaoguang. Analysis of the critical values of partial coagulation function indicators in 1 057 neonates in the early stages of life[J]. Chinese Journal of General Practice, 2023, 21(3): 361-364. doi: 10.16766/j.cnki.issn.1674-4152.002883
shu

Analysis of the critical values of partial coagulation function indicators in 1 057 neonates in the early stages of life

doi: 10.16766/j.cnki.issn.1674-4152.002883
  • 1.

    Department of Neonatology, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong 518000, China

Funds:

 202002030008

 81741086

  • Received Date: 2023-01-09
    Available Online: 2023-04-19
    Abstract
  •   Objective  To investigate the critical values of four coagulation indexes in neonates of different gestational ages at the beginning of life.  Methods  A total of 1 110 eligible newborns hospitalized in 3 level-A tertiary hospitals in Shenzhen from January 1, 2012 to December 31, 2021 were selected. Based on the gestational age, they were divided into early preterm infants, middle preterm infants, late preterm infants and term infants, and four indicators of coagulation function were detected within 24 hours after admission. To establish the reference ranges of four critical values of neonatal coagulation function in the early stage of life, and to determine the condition of 1 588 neonates admitted to the Eighth Affiliated Hospital of Sun Yat-sen University during the same period.  Results  The critical values of coagulation function in early preterm infants were APTT ≥96.6 s or ≤46.7 s, PT ≥21.4 s or ≤12.5 s, TT ≥23.9 s or ≤15.7 s, FIB ≥3.1 g/L or ≤0.9 g/L; In medium preterm infants were APTT ≥92.4 s or ≤49.1 s, PT ≥18.9 s or ≤12.3 s, TT ≥23.5 s or ≤15.4 s, FIB ≥3.0 g/L or ≤1.1 g/L; In Late premature infants were APTT ≥93.4 s or ≤54.8 s, PT ≥17.1 s or ≤12.5 s, TT ≥19.3 s or ≤15.3 s, FIB ≥2.2 g/L or ≤1.1 g/L; In full-term infants were APTT ≥77.6 s or ≤42.0 s, PT ≥17.4 s or ≤12.2 s, TT ≥19 s or ≤14.5 s, FIB ≥2.4 g/L or ≤1.3 g/L. Among the 1 588 neonates, the detection rate of critical values in early preterm infants was 12.61% (14/111), mainly respiratory distress syndrome; the detection rate of critical values in mid-term preterm infants was 10.99% (21/191), mainly respiratory distress syndrome and neonatal hemorrhagic diseases. The detection rate of critical values in late preterm infants was 5.33% (25/469), mainly neonatal hyperbilirubinemia, neonatal hemorrhagic diseases and neonatal asphyxia. The detection rate of critical values in full-term infants was 4.28% (35/817), mainly neonatal hemorrhagic diseases and neonatal asphyxia.  Conclusion  The reference ranges of four critical values of coagulation function in neonates with different gestational ages at the early stage of life have been established, which has an important reference value for predicting the condition of severe neonates.

     

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