Volume 21 Issue 3
Mar.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(3): 369-373
WANG Congying, ZHANG Fan. Establishment of a nomogram prediction model for the risk of hypoxic-ischemic encephalopathy in neonates with intrauterine distress[J]. Chinese Journal of General Practice, 2023, 21(3): 369-373. doi: 10.16766/j.cnki.issn.1674-4152.002885
Citation: WANG Congying, ZHANG Fan. Establishment of a nomogram prediction model for the risk of hypoxic-ischemic encephalopathy in neonates with intrauterine distress[J]. Chinese Journal of General Practice, 2023, 21(3): 369-373. doi: 10.16766/j.cnki.issn.1674-4152.002885
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Establishment of a nomogram prediction model for the risk of hypoxic-ischemic encephalopathy in neonates with intrauterine distress

doi: 10.16766/j.cnki.issn.1674-4152.002885

  • Department of Neonatology, Huaian Second People ' s Hospital, Huaian, Jiangsu 223022, China

Funds:

 F202029

  • Received Date: 2022-11-28
    Available Online: 2023-04-19
    Abstract
  •   Objective  To analyze the risk factors for hypoxic-ischemic encephalopathy (HIE) in neonates with intrauterine distress, and to develop a personalized nomograph prediction model.  Methods  Ninety-six neonates with exposure factors of intrauterine distress and HIE (case group) treated in the Neonatology Department of Huaian Second People ' s Hospital from January 2017 to December 2021 were collected, 96 neonates with exposure factors of intrauterine distress who did not develop HIE (control group) treated in our hospital during the same period were selected. Logistic regression analysis was performed to screen the risk factors affecting the risk of HIE in neonates with intrauterine distress; R software was used to construct a nomogram model to predict the risk of HIE in neonates with intrauterine distress, and the model was meanwhile validated.  Results  1 min Apgar score < 7 points (P < 0.001), irregular prenatal examination (P=0.003), pregnancy-induced hypertension (P < 0.001), abnormal umbilical cord (P=0.043), abnormal labor process (P=0.001), pH < 7.0 (P=0.009), alkaline residue < -12.0 mmol/L (P=0.003) were independent risk factors for HIE in neonates with intrauterine distress. The area under the ROC curve was 0.875 (95% CI: 0.826-0.925). The slope of the calibration curve was close to 1, and the H-L goodness-of-fit test χ2=7.221, P=0.513.  Conclusion  1 min Apgar score < 7, irregular prenatal examination, pregnancy induced hypertension, umbilical cord abnormality, abnormal labor process, pH < 7.0, and alkaline residue < -12.0 mmol/L are all independent risk factors for HIE in neonates with intrauterine distress. The nomograph prediction model constructed using the above indicators has good predictive power and can accurately predict the risk of HIE in neonates with intrauterine distress.

     

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    • References(20)
  • [1]
    陈莉, 陈信. 持续脑功能监测在新生儿缺氧缺血性脑病的应用效果[J]. 中华全科医学, 2020, 18(4): 564-567. doi: 10.16766/j.cnki.issn.1674-4152.001299

    CHEN L, CHEN X. Effect of continuous brain function monitoring on neonatal hypoxic-ischemic encephalopathy[J]. Chinese Journal of General Practice, 2020, 18(4): 564-567. doi: 10.16766/j.cnki.issn.1674-4152.001299
    [2]
    GRECO P, NENCINI G, PIVA I, et al. Pathophysiology of hypoxic-ischemic encephalopathy: a review of the past and a view on the future[J]. Acta Neurol Belg, 2020, 120(2): 277-288. doi: 10.1007/s13760-020-01308-3
    [3]
    刘珍, 赵延凤, 魏莹亚, 等. 新生儿发生缺氧缺血性脑病的影响因素分析[J]. 临床医学研究与实践, 2020, 5(30): 1-2, 6. https://www.cnki.com.cn/Article/CJFDTOTAL-YLYS202030002.htm

    LIU Z, ZHAO Y F, WEI Y Y, et al. Analysis of influencing factors of neonatal hypoxic ischemic encephalopathy[J]. Clinical Research and Practice, 2020, 5(30): 1-2, 6. https://www.cnki.com.cn/Article/CJFDTOTAL-YLYS202030002.htm
    [4]
    于扬, 司振妍, 吕聪聪. 3.0T核磁共振磁敏感加权成像在新生儿缺氧缺血性脑病诊断中的价值分析[J]. 中国基层医药, 2019, 26(3): 272-275. doi: 10.3760/cma.j.issn.1008-6706.2019.03.005

    YU Y, SI Z Y, LYU C C. Clinical value of 3.0T magnetic resonance magnetic sensitive weighted imaging in the diagnosis of neonatal hypoxic ischemic encephalopathy[J]. Chinese Journal of Primary Medicine and Pharmacy, 2019, 26(3): 272-275. doi: 10.3760/cma.j.issn.1008-6706.2019.03.005
    [5]
    付仕强, 邓小梅, 张程. 头针联合康复训练对缺氧缺血性脑病患儿近期预后的影响[J]. 海南医学, 2017, 28(14): 2375-2377. doi: 10.3969/j.issn.1003-6350.2017.14.046

    FU S Q, DENG X M, ZHANG C. Influence of scalp acupuncture combined with rehabilitation training on the short-term prognosis of children with hypoxic ischemic encephalopathy[J]. Hainan Medical Journal, 2017, 28(14): 2375-2377. doi: 10.3969/j.issn.1003-6350.2017.14.046
    [6]
    YASUDA S, SUZUKI H, HTUN Y, et al. Hour-specific nomogram for transcutaneous Bilirubin in newborns in Myanmar[J]. Pediatr Int, 2020, 62(9): 1049-1053. doi: 10.1111/ped.14251
    [7]
    HESS D R. A nomogram for use of non-invasive respiratory strategies in COVID-19[J]. Lancet Digit Health, 2021, 3(3): e140-e141. doi: 10.1016/S2589-7500(21)00006-6
    [8]
    谢幸, 苟文丽. 妇产科学[M]. 8版. 北京: 人民卫生出版社, 2013: 118-120.

    XIE X, GOU W L. Gynecology and Obstetrics[M]. 8th Ed. Beijing: People's Medical Publishing House, 2013: 118-120.
    [9]
    果崇慧, 杨青. 神经节苷脂治疗新生儿缺氧缺血性脑病对患儿血清炎症相关细胞因子和MMP-9的影响[J]. 河北医药, 2018, 40(2): 219-223. https://www.cnki.com.cn/Article/CJFDTOTAL-HBYZ201802014.htm

    GUO Z H, YANG Q. Effects of ganglioside on serum inflammatory cytokines and MMP-9 in neonates with hypoxic-ischemic encephalopathy[J]. Hebei Medical Journal, 2018, 40(2): 219-223. S https://www.cnki.com.cn/Article/CJFDTOTAL-HBYZ201802014.htm
    [10]
    WASSINK G, DAVIDSON J O, DHILLON S K, et al. Therapeutic hypothermia in neonatal hypoxic-ischemic encephalopathy[J]. Curr Neurol Neurosci Rep, 2019, 19(2): 2.
    [11]
    CNATTINGIUS S, JOHANSSON S, RAZAZ N. Apgar score and risk of neonatal death among preterm infants[J]. N Engl J Med, 2020, 383(1): 49-57. doi: 10.1056/NEJMoa1915075
    [12]
    赵燕凤, 张志群, 芦蕙, 等. 脐动脉血气分析联合Apgar评分对新生儿窒息多器官损害的诊断意义[J]. 中华全科医学, 2017, 15(2): 267-269. doi: 10.16766/j.cnki.issn.1674-4152.2017.02.026

    ZHAO Y F, ZHANG Z Q, LU H, et al. Umbilical artery blood gas analysis and Apgar score for multiple organ damage after neonatal asphyxia[J]. Chinese Journal of General Practice, 2017, 15(2): 267-269. doi: 10.16766/j.cnki.issn.1674-4152.2017.02.026
    [13]
    BUTT T K, FAROOQUI R, KHAN M A. Risk factors for hypoxic ischemic encephalopathy in children[J]. J Coll Physicians Surg Pak, 2008, 18(7): 428-432.
    [14]
    曹芳, 江余明, 肖佳荔, 等. 新生儿缺氧缺血性脑病的影响因素及不同亚低温时间窗治疗效果分析[J]. 中国基层医药, 2022, 29(9): 1369-1374.

    CAO F, JIANG Y M, XIAO J L, et al. Influential factors of neonatal hypoxic ischemic encephalopathy and the therapeutic effects of mild hypothermia at different time windows[J]. Chinese Journal of Primary Medicine and Pharmacy, 2022, 29(9): 1369-1374.
    [15]
    尹崇兰. 新生儿缺血缺氧性脑病发生的相关危险因素研究[J]. 中国妇幼健康研究, 2017, 28(6): 630-631, 635. https://www.cnki.com.cn/Article/CJFDTOTAL-SANE201706004.htm

    YIN C L. Risk factors of neonatal hypoxic ischemia encephalopathy[J]. Chinese Journal of Woman and Child Health Research, 2017, 28(6): 630-631, 635. https://www.cnki.com.cn/Article/CJFDTOTAL-SANE201706004.htm
    [16]
    NASIELL J, PAPADOGIANNAKIS N, LÖF E, et al. Hypoxic ischemic encephalopathy in newborns linked to placental and umbilical cord abnormalities[J]. J Matern Fetal Neonatal Med, 2016, 29(5): 721-726.
    [17]
    TORBENSON V E, TOLCHER M C, NESBITT K M, et al. Intrapartum factors associated with neonatal hypoxic ischemic encephalopathy: a case-controlled study[J]. BMC Pregnancy Childbirth, 2017, 17(1): 415.
    [18]
    FERREIRA C S, MELO Â, FACHADA A H, et al. Umbilical cord blood gas analysis, obstetric performance and perinatal outcome[J]. Rev Bras Ginecol Obstet, 2018, 40(12): 740-748.
    [19]
    LILJESTROM L, WIKSTROM A K, AGREN J, et al. Antepartum risk factors for moderate to severe neonatal hypoxic ischemic encephalopathy: a Swedish national cohort study[J]. Acta Obstet Gynecol Scand, 2018, 97(5): 615-623.
    [20]
    PEEBLES P J, DUELLO T M, EICKHOFF J C, et al. Antenatal and intrapartum risk factors for neonatal hypoxic ischemic encephalopathy[J]. J Perinatol, 2020, 40(1): 63-69.
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