Volume 21 Issue 3
Mar.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(3): 381-384
ZENG Chaochao, HU Qingtian, WANG Yuexiang, GENG Zhijun, HU Sigan, LIU Jinjun, LI Miaonan. The level and significance of HIGD-1A and HIGD-1B protein in patients with acute coronary syndrome[J]. Chinese Journal of General Practice, 2023, 21(3): 381-384. doi: 10.16766/j.cnki.issn.1674-4152.002888
Citation: ZENG Chaochao, HU Qingtian, WANG Yuexiang, GENG Zhijun, HU Sigan, LIU Jinjun, LI Miaonan. The level and significance of HIGD-1A and HIGD-1B protein in patients with acute coronary syndrome[J]. Chinese Journal of General Practice, 2023, 21(3): 381-384. doi: 10.16766/j.cnki.issn.1674-4152.002888
shu

The level and significance of HIGD-1A and HIGD-1B protein in patients with acute coronary syndrome

doi: 10.16766/j.cnki.issn.1674-4152.002888
  • 1.

    Department of Cardiovascular Medicine, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2021A0818

 KJ2018A0219

  • Received Date: 2022-04-12
    Available Online: 2023-04-19
    Abstract
  •   Objective  To detect serum hypoxia induced genetic structure domain protein-1A (HIGD-1A) and hypoxia induced genetic structure domain protein-1B (HIGD-1B) protein levels in patients with acute coronary syndrome (ACS) and analyze their relationship with the development of ACS.  Methods  A total of 106 patients with acute coronary syndrome (ACS) diagnosed by coronary angiography in the Department of Cardiovascular Medicine, the First Affiliated Hospital of Bengbu Medical College from September 2019 to September 2021 were selected, including 50 patients with acute myocardial infarction (AMI), 56 patients with unstable angina pectoris (UAP), and 20 patients with stable angina pectoris (SAP). Thirty-four patients with normal coronary angiography during the same period were selected as the normal group. The protein levels of HIGD-1A and HIGD-1B were detected by ELISA to evaluate the differences between the groups.  Results  Serum HIGD-1B protein was statistically significant between the ACS and control group (P < 0.001). There was no significant difference in HIGD-1A protein among ACS group, SAP group and normal group (P=0.123). According to Gensini score, the degree of coronary artery disease was divided into mild group (n=29), moderate group (n=40) and severe group (n=37). There was a significant difference in HIGD-1B level among patients with different degrees of coronary artery disease in ACS group (P < 0.001). Pearson correlation analysis showed that HIGD-1B level was positively correlated with Gensini score in ACS group (r=0.685, P < 0.001). When drawing ROC curve, the AUC of serum HIGD-1B level in predicting acute coronary syndrome was 0.940, the sensitivity was 84.0%, the specificity was 94.1%, and the Youden index was 0.781, which had certain diagnostic reference value.  Conclusion  The serum HIGD-1B protein is significantly elevated in patients with acute coronary syndromes and positively correlated with coronary severity, which is of great significance for the diagnosis of ACS.

     

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