Volume 21 Issue 3
Mar.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(3): 420-422
GUO Yinli, YU Jian, SHEN Junwen. Efficacy and safety of flexible ureteroscopic holmium laser lithotripsy in the treatment of ureteral calculi with hydronephrosis[J]. Chinese Journal of General Practice, 2023, 21(3): 420-422. doi: 10.16766/j.cnki.issn.1674-4152.002898
Citation: GUO Yinli, YU Jian, SHEN Junwen. Efficacy and safety of flexible ureteroscopic holmium laser lithotripsy in the treatment of ureteral calculi with hydronephrosis[J]. Chinese Journal of General Practice, 2023, 21(3): 420-422. doi: 10.16766/j.cnki.issn.1674-4152.002898
shu

Efficacy and safety of flexible ureteroscopic holmium laser lithotripsy in the treatment of ureteral calculi with hydronephrosis

doi: 10.16766/j.cnki.issn.1674-4152.002898
  • 1.

    Department of Urology Surgery, Zhoushan Branch of Shanghai Ruijin Hospital, Zhoushan, Zhejiang 316000, China

Funds:

 2020KY937

  • Received Date: 2022-10-20
    Available Online: 2023-04-19
    Abstract
  •   Objective  Flexible ureteroscopic holmium laser lithotripsy (FUHLL) was a minimally invasive operation that uses natural anatomical channels to reach the lesion, and can quickly relieve the obstruction. This study aims to explore the efficacy and safety of FUHLL in the treatment of ureteral calculi with hydronephrosis.  Methods  A total of 280 cases of ureteral calculi with hydronephrosis treated in Zhoushan Branch of Shanghai Ruijin Hospital from January 2020 to December 2021 were randomly divided into observation group (140 cases) and control group (140 cases). The observation group was treated with FUHLL, and the control group was treated with ureteroscopic holmium laser lithotripsy (UHLL). The renal function indexes and serum inflammatory factor levels of the two groups were measured before and 3 days after treatment. The pain degree was evaluated with visual analogue scale (VAS) scale on the first, second and third days after operation. The stone clearance and operation related indexes were compared between the two groups.  Results  Compared with the control group, the serum levels of IL-10, IL-6, PCT and CRP in the observation group were significantly lower after treatment [(17.59±4.35) ng/L vs. (20.16±5.08) ng/L, (12.52±3.17) ng/L vs. (16.97±5.29) ng/L, (19.76±4.13) ng/L vs. (22.53±4.91) ng/L, (11.76±2.24) mg/L vs. (16.31±3.19) mg/L, all P < 0.05]. Compared with the control group, the serum adrenocorticotrophin (ACTH) in the observation group were significantly lower after treatment (P < 0.05). While there was no significant difference in serum urea nitrogen and blood creatinine levels between the two groups after treatment (all P>0.05). Compared with the control group, the VAS scale scores after surgery were lower in the observation group at 1 d, 2 d and 3 d after operation (P < 0.05). The amount of intraoperative bleeding, duration of surgery and length of hospital stay between the two groups were significantly different (all P < 0.05). There was no significant difference in hospitalization costs and successful rate of one-time stone removal between the two groups (all P>0.05). Compared with the control group, the incidence of postoperative complications in the observation group was lower (P < 0.05).  Conclusion  Both FUHLL and UHLL can effectively treat ureteral calculi with hydronephrosis. However, the surgical trauma of FUHLL is less, which can reduce the postoperative inflammatory response and pain, and it is beneficial to protect renal function and reduce postoperative complications.

     

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