Volume 21 Issue 3
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(3): 481-484
PAN Xianli, SU Zengfeng. Correlation between insomnia and telomere length and aging[J]. Chinese Journal of General Practice, 2023, 21(3): 481-484. doi: 10.16766/j.cnki.issn.1674-4152.002912
Citation: PAN Xianli, SU Zengfeng. Correlation between insomnia and telomere length and aging[J]. Chinese Journal of General Practice, 2023, 21(3): 481-484. doi: 10.16766/j.cnki.issn.1674-4152.002912
shu

Correlation between insomnia and telomere length and aging

doi: 10.16766/j.cnki.issn.1674-4152.002912

  • Department of General Medicine, Chaohu Hospital Affiliated to Anhui Medical University, Chaohu, Anhui 238000, China

Funds:

 KJ2020A0189

 2020xkj219

  • Received Date: 2022-01-12
    Available Online: 2023-04-19
    Abstract
  • Sleep is a neurochemical process regulated by sleep promotion and arousal centres in the brain. Circadian rhythm stability decreases with age, and the prevalence of sleep disorders increases. Insomnia is the most common sleep disorder, and it affects millions of people and has profound consequences for individuals and society. The sleep pattern, sleep duration and quality of elderly have undergone significant changes, such as sleep fragmentation, early awakening, slow wave sleep reduction and significantly increased incidence of insomnia, compared with those of young and middle-aged individuals. Long-term serious insomnia not only affects the quality of life of patients but also increases the risk of some diseases and mortality. The mechanism of age-related changes in sleep patterns is not fully understood, and whether insomnia is a normal part of aging remains unclear. Telomeres are the ends of eukaryotic chromosomes that protect chromosome ends, maintain genome stability during transcription, and play a central role in the control of cell and body aging. Shortening of telomere length or changes in telomere structure can eventually lead to replicative senescence in cells and chromosomal instability, which are both markers of senescence. Aging is an inevitable consequence of life. In most organisms, the rate of aging is inversely proportional to average life span. Aging is also the biggest risk factor for cancer, neurodegeneration and cardiovascular diseases. Two studies were conducted on the relationship between insomnia and telomere length and aging, however, a systematic review of such studies is lacking. This paper will elaborate three aspects, namely, influence of insomnia on telomere length, significance of telomere length on aging and the effects of insomnia on aging.

     

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