Volume 21 Issue 4
Apr.  2023
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(4): 555-559
ZHAO Tianhao, YANG Yiqun, LI Yuetong, ZHANG Xiaofeng, WANG Yueyue, GENG Zhijun, LI Jing, ZUO Lugen, GE Sitang, SONG Xue, DENG Min. Expression and clinical significance of UBE2S in gastric cancer[J]. Chinese Journal of General Practice, 2023, 21(4): 555-559. doi: 10.16766/j.cnki.issn.1674-4152.002929
Citation: ZHAO Tianhao, YANG Yiqun, LI Yuetong, ZHANG Xiaofeng, WANG Yueyue, GENG Zhijun, LI Jing, ZUO Lugen, GE Sitang, SONG Xue, DENG Min. Expression and clinical significance of UBE2S in gastric cancer[J]. Chinese Journal of General Practice, 2023, 21(4): 555-559. doi: 10.16766/j.cnki.issn.1674-4152.002929
shu

Expression and clinical significance of UBE2S in gastric cancer

doi: 10.16766/j.cnki.issn.1674-4152.002929
  • 1.

    Department of Gastroenterology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 2008085MH282

 KJ2020A0563

 KJ2020A0550

  • Received Date: 2022-05-11
    Available Online: 2023-05-31
    Abstract
  •   Objective  To investigate the expression of ubiquitin-binding enzyme 2S (UBE2S) in gastric cancer (GC) tissues, and to explore its relationship with the long-term prognosis of GC patients.  Methods  A total of 101 GC patients admitted to Department of Gastrointestinal Surgery, the First Affiliated Hospital of Bengbu Medical College from January 2016 to December 2016 were selected as the study subjects.Tumor tissue and clinical information of all patients were collected.UBE2S protein levels in cancer and adjacent tissues were detected by immunohistochemistry, and the relationship between UBE2S and histopathological detection values was analyzed.The effect of UBE2S expression on GC prognosis was investigated and survival curve was drawn.Bioinformatics methods were used to analyze the possible mechanism of UBE2S involved in tumor.  Results  Immunohistochemical analysis showed that the expression of UBE2S in GC tissues was significantly higher than that in adjacent tissues.The positive expression of UBE2S was significantly correlated with CEA, CA19-9, T stage and N stage (P < 0.01).Multivariate analysis suggested that UBE2S was an independent risk factor for gastric cancer (HR=2.832, 95%CI: 1.361-4.170, P < 0.01).Kaplan-Meier survival curve showed that the postoperative survival rate of GC patients was discrepant from different UBE2S expression (log-rank χ2=27.512, P < 0.01).ROC curve results showed AUC=0.789, sensitivity and specificity were 77.42% and 74.36%, respectively.  Conclusion  UBE2S is highly expressed in GC, which is closely related to the prognosis of GC.The high expression of UBE2S may be an independent risk factor for postoperative survival in patients with GC.

     

    • FullText(HTML)
  • loading
    • References(17)
  • [1]
    SUNG H, FERLAY J, SIEGEL R L, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249. doi: 10.3322/caac.21660
    [2]
    BERGQUIST J R, LEITING J L, HABERMANN E B, et al. Early-onset gastric cancer is a distinct disease with worrisome trends and oncogenic features[J]. Surgery, 2019, 166(4): 547-555. doi: 10.1016/j.surg.2019.04.036
    [3]
    WONG M C S, HUANG J J, CHAN P S F, et al. Global incidence and mortality of gastric cancer, 1980-2018[J]. JAMA Netw Open, 2021, 4(7): e2118457. DOI: 10.1001/jamanetworkopen.2021.18457.
    [4]
    ALLEMANI C, MATSUDA T, DI CARLO V, et al. Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries[J]. Lancet, 2018, 391(10125): 1023-1075. doi: 10.1016/S0140-6736(17)33326-3
    [5]
    INOKUCHI M, NAKAGAWA M, TANIOKA T, et al. Long- and short-term outcomes of laparoscopic gastrectomy versus open gastrectomy in patients with clinically and pathological locally advanced gastric cancer: a propensity-score matching analysis[J]. Surg Endosc, 2018, 32(2): 735-742. doi: 10.1007/s00464-017-5730-7
    [6]
    DESHAIES R J, JOAZEIRO C A. RING domain E3 ubiquitin ligases[J]. Annu Rev Biochem, 2009, 78: 399-434. doi: 10.1146/annurev.biochem.78.101807.093809
    [7]
    郑智, 尹杰, 张军, 等. 泛素特异性蛋白酶在肿瘤演进过程中的研究进展[J]. 国际外科学杂志, 2021, 48(11): 774-777. doi: 10.3760/cma.j.issn115396-20201001-00302

    ZHENG Z, YIN J, ZHANG J, et al. Research progress of ubiquitin-specific peptidases in tumorigenesis and development[J]. International Journal of Surgery, 2021, 48(11): 774-777. doi: 10.3760/cma.j.issn115396-20201001-00302
    [8]
    LI Z Y, WANG Y, LI Y D, et al. UBE2S stabilizes β-Catenin through K11-linked polyubiquitination to promote mesendoderm specification and colorectal cancer development[J]. Cell Death Dis, 2018, 9(5): 456. doi: 10.1038/s41419-018-0451-y
    [9]
    QIN Y N, DU J, FAN C F. UBE2S regulates Wnt/β-catenin signaling and promotes the progression of non-small cell lung cancer[J]. Int J Med Sci, 2020, 17(2): 274-279. doi: 10.7150/ijms.40243
    [10]
    LIN M F, LEI T, ZHENG J, et al. UBE2S mediates tumor progression via SOX6/β-Catenin signaling in endometrial cancer[J]. Int J Biochem Cell Biol, 2019, 109: 17-22. doi: 10.1016/j.biocel.2019.01.014
    [11]
    EUSEBI L H, TELESE A, MARASCO G, et al. Gastric cancer prevention strategies: a global perspective[J]. J Gastroenterol Hepatol, 2020, 35(9): 1495-1502. doi: 10.1111/jgh.15037
    [12]
    梁松, 江频, 李靖, 等. 中老年早期胃癌浸润深度相关因素分析及其与淋巴结转移的关系[J]. 中华全科医学, 2021, 19(7): 1084-1086, 1149. doi: 10.16766/j.cnki.issn.1674-4152.001990

    LIANG S, JIANG P, LI J, et al. Analysis of the related factors of the invasion depth of gastric cancer in middle-aged and elderly patients[J]. Chinese Journal of General Practice, 2021, 19(7): 1084-1086, 1149. doi: 10.16766/j.cnki.issn.1674-4152.001990
    [13]
    MARTINEZ-CHACIN R C, BODRUG T, BOLHUIS D L, et al. Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming[J]. Nat Struct Mol Biol, 2020, 27(6): 550-560. doi: 10.1038/s41594-020-0424-6
    [14]
    KIRKPATRICK D S, HATHAWAY N A, HANNA J, et al. Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology[J]. Nat Cell Biol, 2006, 8(7): 700-710. doi: 10.1038/ncb1436
    [15]
    YE Y, RAPE M. Building ubiquitin chains: E2 enzymes at work[J]. Nat Rev Mol Cell Biol, 2009, 10(11): 755-764. doi: 10.1038/nrm2780
    [16]
    SCARBROUGH P M, WEBER R P, IVERSEN E S, et al. A cross-cancer genetic association analysis of the DNA repair and DNA damage signaling pathways for lung, ovary, prostate, breast, and colorectal cancer[J]. Cancer Epidemiol Biomarkers Prev, 2016, 25(1): 193-200. doi: 10.1158/1055-9965.EPI-15-0649
    [17]
    KIM Y, CHOI J W, LEE J H, et al. Spindle assembly checkpoint MAD2 and CDC20 overexpressions and cell-in-cell formation in gastric cancer and its precursor lesions[J]. Hum Pathol, 2019, 85: 174-183. doi: 10.1016/j.humpath.2018.10.029
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(5)  / Tables(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (328) PDF downloads(13) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return