Volume 21 Issue 4
Apr.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(4): 555-559
ZHAO Tianhao, YANG Yiqun, LI Yuetong, ZHANG Xiaofeng, WANG Yueyue, GENG Zhijun, LI Jing, ZUO Lugen, GE Sitang, SONG Xue, DENG Min. Expression and clinical significance of UBE2S in gastric cancer[J]. Chinese Journal of General Practice, 2023, 21(4): 555-559. doi: 10.16766/j.cnki.issn.1674-4152.002929
Citation: ZHAO Tianhao, YANG Yiqun, LI Yuetong, ZHANG Xiaofeng, WANG Yueyue, GENG Zhijun, LI Jing, ZUO Lugen, GE Sitang, SONG Xue, DENG Min. Expression and clinical significance of UBE2S in gastric cancer[J]. Chinese Journal of General Practice, 2023, 21(4): 555-559. doi: 10.16766/j.cnki.issn.1674-4152.002929
shu

Expression and clinical significance of UBE2S in gastric cancer

doi: 10.16766/j.cnki.issn.1674-4152.002929
  • 1.

    Department of Gastroenterology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 2008085MH282

 KJ2020A0563

 KJ2020A0550

  • Received Date: 2022-05-11
    Available Online: 2023-05-31
    Abstract
  •   Objective  To investigate the expression of ubiquitin-binding enzyme 2S (UBE2S) in gastric cancer (GC) tissues, and to explore its relationship with the long-term prognosis of GC patients.  Methods  A total of 101 GC patients admitted to Department of Gastrointestinal Surgery, the First Affiliated Hospital of Bengbu Medical College from January 2016 to December 2016 were selected as the study subjects.Tumor tissue and clinical information of all patients were collected.UBE2S protein levels in cancer and adjacent tissues were detected by immunohistochemistry, and the relationship between UBE2S and histopathological detection values was analyzed.The effect of UBE2S expression on GC prognosis was investigated and survival curve was drawn.Bioinformatics methods were used to analyze the possible mechanism of UBE2S involved in tumor.  Results  Immunohistochemical analysis showed that the expression of UBE2S in GC tissues was significantly higher than that in adjacent tissues.The positive expression of UBE2S was significantly correlated with CEA, CA19-9, T stage and N stage (P < 0.01).Multivariate analysis suggested that UBE2S was an independent risk factor for gastric cancer (HR=2.832, 95%CI: 1.361-4.170, P < 0.01).Kaplan-Meier survival curve showed that the postoperative survival rate of GC patients was discrepant from different UBE2S expression (log-rank χ2=27.512, P < 0.01).ROC curve results showed AUC=0.789, sensitivity and specificity were 77.42% and 74.36%, respectively.  Conclusion  UBE2S is highly expressed in GC, which is closely related to the prognosis of GC.The high expression of UBE2S may be an independent risk factor for postoperative survival in patients with GC.

     

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