Volume 21 Issue 4
Apr.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(4): 565-567
YIN Shuqin, WANG Lina. A study on protective factors related to the early stages of Alzheimer' s disease[J]. Chinese Journal of General Practice, 2023, 21(4): 565-567. doi: 10.16766/j.cnki.issn.1674-4152.002931
Citation: YIN Shuqin, WANG Lina. A study on protective factors related to the early stages of Alzheimer' s disease[J]. Chinese Journal of General Practice, 2023, 21(4): 565-567. doi: 10.16766/j.cnki.issn.1674-4152.002931
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A study on protective factors related to the early stages of Alzheimer' s disease

doi: 10.16766/j.cnki.issn.1674-4152.002931
  • 1.

    School of Medicine, Huzhou Normal University, Huzhou, Zhejiang 313000, China

Funds:

 81373078

 72174061

  • Received Date: 2022-12-15
    Available Online: 2023-05-31
    Abstract
  •   Objective  To explore the influencing factors of early mild cognitive impairment in Alzheimer's disease and provide guidance for the prevention of cognitive impairment in Alzheimer's disease.  Methods  From January 2021 to January 2022, the elderly in 5 communities in Huzhou City were selected as the research objects, of which a total of 300 elderly patients with mild cognitive impairment (MCI) were selected as the research group, and 300 normal elderly people were selected as the control group.The cognitive activity score, education and socio-economic status, self-rating depression scale (SDS), and neuropsychological tests of the patients were evaluated, and the influence and protective effect of related factors on cognitive deficits were analyzed.  Results  The MMSE score of MCI patients (25.0±1.4) was significantly lower than that of the control group (28.9±1.1).The SDS score (35.5±4.5) was significantly higher than that of the control group (32.0±4.6), and the differences were statistically significant (all P < 0.05).There were statistically significant differences in terms of mean years of education, CAS and SES between the groups (all P < 0.05).After logistic multiple regression analysis, the results showed that high educational background, high CAS grade and high SES grade were protective factors for the development of Alzheimer's disease (all P < 0.05).  Conclusion  Higher levels of cognitive activity and socio-economic status, as well as higher education in community-based elderly patients are significant protective factors against the risk of dementia in Alzheimer's disease.

     

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