Application of low molecular weight heparin combined with unfractionated heparin in direct thrombolysis of lower extremity deep vein thrombosis

WANG Ying; WANG Xiaogao; GUAN Zeyu; Ayoade Philip Adegoke; GAO Yong; YU Chaowen; CHEN Shiyuan; LU Ran

doi:10.16766/j.cnki.issn.1674-4152.002932

Volume 21 Issue 4

Apr. 2023

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Article Navigation > Chinese Journal of General Practice > 2023 > 21(4): 568-571

WANG Ying, WANG Xiaogao, GUAN Zeyu, Ayoade Philip Adegoke, GAO Yong, YU Chaowen, CHEN Shiyuan, LU Ran. Application of low molecular weight heparin combined with unfractionated heparin in direct thrombolysis of lower extremity deep vein thrombosis[J]. Chinese Journal of General Practice, 2023, 21(4): 568-571. doi: 10.16766/j.cnki.issn.1674-4152.002932

Citation:

WANG Ying, WANG Xiaogao, GUAN Zeyu, Ayoade Philip Adegoke, GAO Yong, YU Chaowen, CHEN Shiyuan, LU Ran. Application of low molecular weight heparin combined with unfractionated heparin in direct thrombolysis of lower extremity deep vein thrombosis[J]. Chinese Journal of General Practice, 2023, 21(4): 568-571. doi: 10.16766/j.cnki.issn.1674-4152.002932

Citation:

WANG Ying, WANG Xiaogao, GUAN Zeyu, Ayoade Philip Adegoke, GAO Yong, YU Chaowen, CHEN Shiyuan, LU Ran. Application of low molecular weight heparin combined with unfractionated heparin in direct thrombolysis of lower extremity deep vein thrombosis[J]. Chinese Journal of General Practice, 2023, 21(4): 568-571. doi: 10.16766/j.cnki.issn.1674-4152.002932

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Application of low molecular weight heparin combined with unfractionated heparin in direct thrombolysis of lower extremity deep vein thrombosis

doi: 10.16766/j.cnki.issn.1674-4152.002932

1.
Department of Biochemistry and Molecular Biology, Laboratory Medical School of Bengbu Medical College, Bengbu, Anhui 233000, China

Funds:

KJ2019A0327

201904a07020020

AHWJ2021a016

2020fyjyxm14

2020byzd67

20200343

Received Date: 2022-02-23
Available Online: 2023-05-31

Abstract

Abstract

Objective To explore the clinical efficacy of different anticoagulation regimens during catheter-directed thrombectomy (CDT) in deep venous thrombosis (DVT) of the lower extremities. Methods A total of 35 DVT patients admitted to the Department of Vascular Surgery of the First Affiliated Hospital of Bengbu Medical College Hospital from March 2021 to February 2022 were selected.They were randomly divided into a low molecular weight heparin+small dose unfractionated heparin pulse group (observation group, 18 cases) and a low molecular weight heparin application group merely (control group, 17 cases) by a random number table method.Thrombolysis effect was assessed by dynamic examination of plasma D-dimer.After treatment completed, the curative effect was analyzed by measuring the difference in the circumference of the lower limbs before and after the operation and the venous patency score. Results The plasma D-dimer in the observation group and control group increased during the thrombolysis process (day 3) were (78.26±11.57) and (66.06±12.31) mg/L (t=3.020, P=0.005).The circumference of 15 cm below the knee joint were (1.43±0.34) and (2.48±0.63) cm (t=6.185, P < 0.001);the lower extremity venous patency score was 5.34±0.90 and 7.29±1.19(t=5.235, P < 0.001);the dosage of urokinase were (302.22±20.45)×10⁴ and (381.17±27.59)×10⁴ units (t=9.656, P < 0.001).The comparison of the above two groups of data was statistically significant. Conclusion The efficacy of low molecular weight heparin combined with small dose unfractionated heparin pulse anticoagulation of CDT in DVT is excellent and safe.It should be popularized and applied in clinical treatment of lower extremity DVT.
- Deep venous thrombosis,
- Thrombectomy,
- Heparin anticoagulation,
- Catheter-directed thrombectomy

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Application of low molecular weight heparin combined with unfractionated heparin in direct thrombolysis of lower extremity deep vein thrombosis

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