Volume 21 Issue 4
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DENG Chenghao, CHEN Kangyu, WANG Qi, WU Guohong, YAN Ji. Association of holter monitoring (24-hour ECG) parameters with improvement in left ventricular ejection fraction in heart failure with reduced ejection fraction[J]. Chinese Journal of General Practice, 2023, 21(4): 572-575. doi: 10.16766/j.cnki.issn.1674-4152.002933
Citation: DENG Chenghao, CHEN Kangyu, WANG Qi, WU Guohong, YAN Ji. Association of holter monitoring (24-hour ECG) parameters with improvement in left ventricular ejection fraction in heart failure with reduced ejection fraction[J]. Chinese Journal of General Practice, 2023, 21(4): 572-575. doi: 10.16766/j.cnki.issn.1674-4152.002933

Association of holter monitoring (24-hour ECG) parameters with improvement in left ventricular ejection fraction in heart failure with reduced ejection fraction

doi: 10.16766/j.cnki.issn.1674-4152.002933
Funds:

 皖科资秘[2019]341号

 KF2018006

  • Received Date: 2022-08-21
    Available Online: 2023-05-31
  •   Objective  To evaluate the association between heart rate variability (HRV) and arrhythmias on the improvement of left ventricular ejection fraction (LVEF) by analyzing the clinical data from patients with heart failure with reduced ejection fraction (HFrEF).  Methods  Among 1 344 HFrEF patients first admitted to Anhui Medical University Provincial Hospital for heart failure from November 2018 to November 2021, a total of 286 HFrEF patients with holter monitoring (24-hour ECG) at baseline and echocardiography followed-up within 1 year were screened, and 210 HFrEF patients with sinus rhythm were used for HRV analysis.Patients were divided into a heart failure with improved ejection fraction (HFimpEF) group and control group according to baseline and follow-up echocardiography.The differences between the 2 groups in baseline clinical data, echocardiographic and 24-hour holter monitoring parameters were compared, and logistic regression analysis was used to investigate the factors influencing the improvement in LVEF.  Results  One hundred and thirty-two patients (46.2%) met the criteria of HFimpEF group, with the remaining 154 patients served as control group.HFimpEF patients were mostly female, with higher the mean of the standard deviations of all normal sinus NN intervals for all 5-min segments (SDNN index).Multifactorial logistic regression analysis showed that arrhythmias index was not an influential factor in LVEF improvement; baseline SDNN index (OR: 1.026, 95%CI: 1.008-1.044, P=0.004) was independently associated with LVEF improvement in patients with sinus rhythm.  Conclusion  In HFrEF patients with sinus rhythm, the SDNN Index is an independent predictor of LVEF improvement.

     

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