Volume 21 Issue 4
Apr.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(4): 589-592
FU Kuan, DUAN Meili, WANG Guoxing. Risk factors for sepsis caused by pyogenic liver abscess[J]. Chinese Journal of General Practice, 2023, 21(4): 589-592. doi: 10.16766/j.cnki.issn.1674-4152.002937
Citation: FU Kuan, DUAN Meili, WANG Guoxing. Risk factors for sepsis caused by pyogenic liver abscess[J]. Chinese Journal of General Practice, 2023, 21(4): 589-592. doi: 10.16766/j.cnki.issn.1674-4152.002937
shu

Risk factors for sepsis caused by pyogenic liver abscess

doi: 10.16766/j.cnki.issn.1674-4152.002937
  • 1.

    Department of Emergency, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

Funds:

 ZYLX201804

  • Received Date: 2023-01-05
    Available Online: 2023-05-31
    Abstract
  •   Objective  To analyze the clinical characteristics of pyogenic liver abscess (PLA), to review the risk factors for sepsis caused by pyogenic liver abscess (PLA) and the laboratory indicators that can predict the occurrence of sepsis at an early stage.  Methods  The clinical data of 131 patients with PLA in Beijing Friendship Hospital, Capital Medical University from January 2019 to December 2020 were retrospectively analyzed. Patients meeting the inclusion criteria were divided into a sepsis group (45 cases) and a non-sepsis group (86 cases). SPSS 26.0 statistical software was used to analyze the clinical data of patients in the two groups, and the risk factors of sepsis caused by PLA were determined by univariate and logistic multivariate analysis. Receiver operating characteristic curve (ROC curve) was used to analyze the diagnostic value of neutrophil ratio, serum creatinine and glucose on admission for the sepsis caused by PLA.  Results  The sepsis group had a higher percentage of males and symptoms of chills, and higher neutrophil percentage, hemoglobin, C-reactive protein, glutamic-pyruvic transaminase, total bilirubin, direct bilirubin, creatinine and glucose levels on admission than the non-sepsis groups, while platelets, sodium and carbon dioxide levels were lower than the non-sepsis group (all P < 0.05). Logistic regression analysis showed that the higher percentage of neutrophil, creatinine and glucose at admission were the risk factors for sepsis caused by bacterial liver abscess (all P < 0.05). ROC curve analysis showed that serum neutrophil ratio and creatinine at admission had better diagnostic value for PLA progressing to sepsis, and the AUC values were 0.815 (95% CI: 0.743-0.886) and 0.760 (95% CI: 0.667-0.854), respectively. When the neutrophil ratio is ≥85.8% and creatinine ≥79.75 μmol/L, one needs to be alert for the progression of PLA to sepsis.  Conclusion  The neutrophil ratio is a good predictor of PLA-induced sepsis. In PLA patients, if the neutrophil ratio is ≥85.8% on admission, it is necessary to prevent the progression of sepsis.

     

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