Volume 21 Issue 4
Apr.  2023
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(4): 589-592
FU Kuan, DUAN Meili, WANG Guoxing. Risk factors for sepsis caused by pyogenic liver abscess[J]. Chinese Journal of General Practice, 2023, 21(4): 589-592. doi: 10.16766/j.cnki.issn.1674-4152.002937
Citation: FU Kuan, DUAN Meili, WANG Guoxing. Risk factors for sepsis caused by pyogenic liver abscess[J]. Chinese Journal of General Practice, 2023, 21(4): 589-592. doi: 10.16766/j.cnki.issn.1674-4152.002937
shu

Risk factors for sepsis caused by pyogenic liver abscess

doi: 10.16766/j.cnki.issn.1674-4152.002937
  • 1.

    Department of Emergency, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

Funds:

 ZYLX201804

  • Received Date: 2023-01-05
    Available Online: 2023-05-31
    Abstract
  •   Objective  To analyze the clinical characteristics of pyogenic liver abscess (PLA), to review the risk factors for sepsis caused by pyogenic liver abscess (PLA) and the laboratory indicators that can predict the occurrence of sepsis at an early stage.  Methods  The clinical data of 131 patients with PLA in Beijing Friendship Hospital, Capital Medical University from January 2019 to December 2020 were retrospectively analyzed. Patients meeting the inclusion criteria were divided into a sepsis group (45 cases) and a non-sepsis group (86 cases). SPSS 26.0 statistical software was used to analyze the clinical data of patients in the two groups, and the risk factors of sepsis caused by PLA were determined by univariate and logistic multivariate analysis. Receiver operating characteristic curve (ROC curve) was used to analyze the diagnostic value of neutrophil ratio, serum creatinine and glucose on admission for the sepsis caused by PLA.  Results  The sepsis group had a higher percentage of males and symptoms of chills, and higher neutrophil percentage, hemoglobin, C-reactive protein, glutamic-pyruvic transaminase, total bilirubin, direct bilirubin, creatinine and glucose levels on admission than the non-sepsis groups, while platelets, sodium and carbon dioxide levels were lower than the non-sepsis group (all P < 0.05). Logistic regression analysis showed that the higher percentage of neutrophil, creatinine and glucose at admission were the risk factors for sepsis caused by bacterial liver abscess (all P < 0.05). ROC curve analysis showed that serum neutrophil ratio and creatinine at admission had better diagnostic value for PLA progressing to sepsis, and the AUC values were 0.815 (95% CI: 0.743-0.886) and 0.760 (95% CI: 0.667-0.854), respectively. When the neutrophil ratio is ≥85.8% and creatinine ≥79.75 μmol/L, one needs to be alert for the progression of PLA to sepsis.  Conclusion  The neutrophil ratio is a good predictor of PLA-induced sepsis. In PLA patients, if the neutrophil ratio is ≥85.8% on admission, it is necessary to prevent the progression of sepsis.

     

    • FullText(HTML)
  • loading
    • References(23)
  • [1]
    王贝贝, 冯婷婷, 赵卫峰, 等. 社区获得性细菌性肝脓肿患者的临床和病原学特征[J]. 中华传染病杂志, 2021, 39(6): 351-357. doi: 10.3760/cma.j.cn311365-20200712-00712

    WANG B B, FENG T T, ZHAO W F, et al. Clinical and pathogenic characteristics of community acquired pyogenic liver abscess[J]. Chinese Journal of Infectious Diseases, 2021, 39(6): 351-357. doi: 10.3760/cma.j.cn311365-20200712-00712
    [2]
    潘教治, 王仙敏, 黄友全, 等. 糖尿病合并细菌性肝脓肿424例临床分析[J]. 中华临床感染病杂志, 2021, 14(3): 199-202. doi: 10.3760/cma.j.issn.1674-2397.2021.03.007

    PAN J Z, XIE D M, WANG X D, et al. Clinical analysis of 424 cases of diabetes mellitus complicated with bacterial liver abscess[J]. Chinese Journal of Clinical Infectious Diseases, 2021, 14(3): 199-202. doi: 10.3760/cma.j.issn.1674-2397.2021.03.007
    [3]
    YOO J J, LEE T K, KYOUNG D S, et al. A population-based study of pyogenic liver abscess in Korea: incidence, mortality and temporal trends during 2007-2017[J]. Liver Int, 2021, 41(11): 2747-2758. doi: 10.1111/liv.15034
    [4]
    LEE C H, JO H G, CHO E Y, et al. Maximal diameter of liver abscess independently predicts prolonged hospitalization and poor prognosis in patients with pyogenic liver abscess[J]. BMC Infect Dis, 2021, 21(1): 171. doi: 10.1186/s12879-021-05873-7
    [5]
    YIN D L, JI C Y, ZHANG S J, et al. Clinical characteristics and management of 1 572 patients with pyogenic liver abscess: a 12-year retrospective study[J]. Liver Int, 2021, 41(4): 810-818. doi: 10.1111/liv.14760
    [6]
    RUDD K E, JOHNSON S C, AGESA K M, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study[J]. Lancet, 2020, 395(10219): 200-211. doi: 10.1016/S0140-6736(19)32989-7
    [7]
    蔡敏杰, 金莹莹, 林荣海, 等. 脓毒症基因多态性的研究新进展[J]. 中华全科医学, 2021, 19(3): 471-475. doi: 10.16766/j.cnki.issn.1674-4152.001838

    CAI M J, JIN Y Y, LIN R H, et al. Recent developments of gene polymorphisms of sepsis[J]. Chinese Journal of General Practice, 2021, 19(3): 471-475. doi: 10.16766/j.cnki.issn.1674-4152.001838
    [8]
    LI S X, YU S F, PENG M F, et al. Clinical features and development of sepsis in Klebsiella pneumoniae infected liver abscess patients: a retrospective analysis of 135 cases[J]. BMC Infect Dis, 2021, 21(1): 597. doi: 10.1186/s12879-021-06325-y
    [9]
    PARK K S, LEE S H, YUN S J, et al. Neutrophil-to-lymphocyte ratio as a feasible prognostic marker for pyogenic liver abscess in the emergency department[J]. Eur J Trauma Emerg Surg, 2019, 45(2): 343-351. doi: 10.1007/s00068-018-0925-8
    [10]
    孙炳伟. 脓毒症时中性粒细胞的生物学行为[J]. 医学研究生学报, 2019, 32(1): 31-36. https://www.cnki.com.cn/Article/CJFDTOTAL-JLYB201901008.htm

    SUN B W. Biological behavior of neutrophils in sepsis[J]. Journal of Medical Postgraduates, 2019, 32(1): 31-36. https://www.cnki.com.cn/Article/CJFDTOTAL-JLYB201901008.htm
    [11]
    KUMAR S, PAYAL N, JYOTI A, et al. Neutrophil extracellular traps and organ dysfunction in sepsis[J]. Clin Chim Acta, 2021, 523: 152-162. doi: 10.1016/j.cca.2021.09.012
    [12]
    阴晴, 刘大东, 邢虎, 等. 应用logistic回归模型和ROC曲线评价外周血感染性指标在脓毒症中的诊断价值[J]. 中国老年学杂志, 2019, 39(12): 2955-2957. doi: 10.3969/j.issn.1005-9202.2019.12.042

    YIN Q, LIU D D, XING H, et al. Logistic regression model and ROC curve were used to evaluate the diagnostic value of peripheral blood infectivity indexes in sepsis[J]. Chinese Journal of Gerontology, 2019, 39(12): 2955-2957. doi: 10.3969/j.issn.1005-9202.2019.12.042
    [13]
    杜俊丽. 血清Neu%、PCT水平与脓毒症患者APACHEⅡ评分的关联性及其临床意义[J]. 临床医学, 2021, 41(7): 45-46. https://www.cnki.com.cn/Article/CJFDTOTAL-EBED202107016.htm

    DJ J L. Correlation between serum Neu%, PCT and APACHE Ⅱ score in patients with sepsis and its clinical significance[J]. Clinical Medicine, 2021, 41(7): 45-46. https://www.cnki.com.cn/Article/CJFDTOTAL-EBED202107016.htm
    [14]
    齐文旗, 黄椿媚, 边帆, 等. 肝脓肿致脓毒血症的危险因素及早期诊断[J]. 中华急诊医学杂志, 2019, 28(11): 1383-1384, 1389. doi: 10.3760/cma.j.issn.1671-0282.2019.11.010

    QI W Q, HUANG C M, BIAN F, et al. Risk factors and early diagnosis of sepsis caused by liver abscess[J]. Chinese Journal of Emergency Medicine, 2019, 28(11): 1383-1384, 1389. doi: 10.3760/cma.j.issn.1671-0282.2019.11.010
    [15]
    杨祎, 章仲恒, 洪玉才, 等. 中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值对脓毒性休克预后的预测价值[J]. 全科医学临床与教育, 2022, 20(2): 170-172. https://www.cnki.com.cn/Article/CJFDTOTAL-QKYL202202021.htm

    YANG Y, ZHANG Z H, HONG Y C, et al. Prognostic value of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in septic shock[J]. Clinical Education of General Practice, 2022, 20(2): 170-172. https://www.cnki.com.cn/Article/CJFDTOTAL-QKYL202202021.htm
    [16]
    ATTAR B M, CABRERA N L, ARAUJO T, et al. Risk factors, management, and outcomes of pyogenic liver abscess in a US Safety Net Hospital[J]. Dig Dis Sci, 2020, 65(5): 1529-1538. doi: 10.1007/s10620-019-05851-9
    [17]
    ZHOU Y Y, LU G Z, BAI Y P, et al. Retrospective study of characteristics and management of pyogenic liver abscess during 5 years' experience[J]. Int J Clin Exp Pathol, 2021, 14(2): 252-260. http://www.ncbi.nlm.nih.gov/pubmed/33564358
    [18]
    赵岩, 李守龙, 王国兴. 超声介入联合抗生素治疗肺炎克雷伯菌肝脓肿临床分析[J]. 中国医师杂志, 2021, 23(10) : 1457-1460.

    ZHAO Y, LI S L, WANG G X. Clinical analysis of ultrasound intervention combined with antibiotics in treatment of Klebsiella pneumoniae liver abscess[J]. Journal of Chinese Physician, 2021, 23(10) : 1457-1460.
    [19]
    张健, 沈振华, 吴小昌. 不同血糖控制水平的化脓性肝脓肿患者临床特点和预后分析[J]. 浙江临床医学, 2022, 24(3): 361-363.

    ZHANG J, SHEN Z H, WU X C. Clinical characteristics and prognosis analysis of pyogenic liver abscess with different levels of serum glucose[J]. Zhejiang Clinical Medical Journal, 2022, 24(3): 361-363
    [20]
    高玉雷, 刘艳存, 王力军, 等. 天津某三甲医院四年急诊脓毒症特点回顾分析[J]. 中华急诊医学杂志, 2022, 31(1): 85-91.

    GAO Y L, LIU Y C, CHAI Y F, et al. Characteristics of sepsis in the emergency department of a tertiary hospital in Tianjin: A 4-year retrospective analysis[J]. Chinese Journal of Emergency Medicine, 2022, 31(1): 85-91.
    [21]
    ALKOMOS M F, ESTIFAN E, MELKI G, et al. Epidemiological, clinical, microbiological, and risk factors of pyogenic liver abscess: an 18-years retrospective single-center analysis[J]. J Community Hosp Intern Med Perspect, 2021, 11(1): 42-45. http://doc.paperpass.com/foreign/rgArti20214256384.html
    [22]
    赵豹, 邬路平, 徐乐珍, 等. 化脓性肝脓肿并发脓毒症的影响因素及其检查评估[J]. 中华医院感染学杂志, 2021, 31(20): 3069-3072. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY202120007.htm

    ZHAO B, WU L P, YE C L, et al. Influencing factors for sepsis in patients with suppurative liver abscess and assessment of test indexes[J]. Chinese Journal of Nosocomiology, 2021, 31(20): 3069-3072. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY202120007.htm
    [23]
    WARDI G, TAINTER C R, MEIER A, et al. Age-related incidence and outcomes of sepsis in California, 2008—2015[J]. J Crit Care, 2021, 62: 212-217. http://www.nstl.gov.cn/paper_detail.html?id=6d9d0b9dc090e39ed24adfafe2e8d1dd
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (184) PDF downloads(21) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return