Volume 21 Issue 4
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(4): 611-614
HUANG Mengdi, CHEN Weidong, LIU Lei. Correlation analysis of serum alkaline phosphatase with calcium and phosphorus metabolism and inflammatory markers in maintenance hemodialysis patients[J]. Chinese Journal of General Practice, 2023, 21(4): 611-614. doi: 10.16766/j.cnki.issn.1674-4152.002942
Citation: HUANG Mengdi, CHEN Weidong, LIU Lei. Correlation analysis of serum alkaline phosphatase with calcium and phosphorus metabolism and inflammatory markers in maintenance hemodialysis patients[J]. Chinese Journal of General Practice, 2023, 21(4): 611-614. doi: 10.16766/j.cnki.issn.1674-4152.002942
shu

Correlation analysis of serum alkaline phosphatase with calcium and phosphorus metabolism and inflammatory markers in maintenance hemodialysis patients

doi: 10.16766/j.cnki.issn.1674-4152.002942

  • Department of Nephrology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 202004j07020011

  • Received Date: 2022-09-15
    Available Online: 2023-05-31
    Abstract
  •   Objective  To investigate the changes of serum alkaline phosphatase (ALP) levels in maintenance hemodialysis (MHD) patients and its clinical application value.  Methods  A total of 736 patients who underwent MHD in five blood purification centers in Bengbu region from October 2020 to May 2021 were included. The patients were grouped according to the quartile of serum ALP. The general data and laboratory indicators of patients in the four groups were statistically compared. Furthermore, the correlation between serum ALP and calcium and phosphorus metabolism and inflammatory indexes was analyzed.  Results  The MHD patients included 415 males (56.39%) and 321 females (43.61%), with an average age of (56.61±13.40) years and a median dialysis age of 44(16, 74) months. The prevalence of hypocalcemia, hyperphosphatemia and secondary hyperparathyroidism (SHPT) were 25.54%, 63.59% and 20.11%, respectively. Among ALP groups, there were statistically significant differences in age, dialysis age, systolic blood pressure, serum calcium, serum phosphorus, calcium-phosphorus product, whole parathyroid hormone (iPTH), creatinine, urea nitrogen, albumin, hs-CRP, white blood cell count (WBC) and ferritin (FER) levels (all P < 0.05). Pearson correlation analysis showed that serum ALP was significantly positively correlated with serum calcium, iPTH, hs-CRP, WBC and FER (all P < 0.05).  Conclusion  Serum ALP combined with blood iPTH monitoring can more accurately identify the types of renal bone disease, and serum ALP level is closely related to inflammatory indicators. Serum ALP can be used as a predictor of cardiovascular disease morbidity and mortality in MHD patients, and is expected to be a new therapeutic target for MHD patients, thereby improving the prognosis of patients.

     

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