Volume 21 Issue 4
Apr.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(4): 626-628
FU Jie, WEI Guangyou, ZHENG Aihua, LIU Jun, SUI Sumin, LIU Jinguang. Effect of nasal intermittent positive pressure ventilation combined with caffeine citrate on apnea of prematurity[J]. Chinese Journal of General Practice, 2023, 21(4): 626-628. doi: 10.16766/j.cnki.issn.1674-4152.002946
Citation: FU Jie, WEI Guangyou, ZHENG Aihua, LIU Jun, SUI Sumin, LIU Jinguang. Effect of nasal intermittent positive pressure ventilation combined with caffeine citrate on apnea of prematurity[J]. Chinese Journal of General Practice, 2023, 21(4): 626-628. doi: 10.16766/j.cnki.issn.1674-4152.002946
shu

Effect of nasal intermittent positive pressure ventilation combined with caffeine citrate on apnea of prematurity

doi: 10.16766/j.cnki.issn.1674-4152.002946

  • NICU, Bozhou People ' s Hospital of Anhui Medical University, Bozhou, Anhui 236800, China

Funds:

 SCE158NE

  • Received Date: 2022-04-21
    Available Online: 2023-05-31
    Abstract
  •   Objective  To investigate the efficacy and safety of intermittent nasal positive pressure ventilation (NIPPV) combined with caffeine citrate in the treatment of premature apnea (AOP), and to clarify the best treatment plan of AOP, so as to improve the clinical treatment level.  Methods  A total of 96 children with AOP in NICU of Bozhou People ' s Hospital from October 2019 to July 2021 were selected and divided into observation group (48 cases, NIPPV+caffeine) and control group (48 cases, nasal continuous positive airway pressure + caffeine) by random number table method. The efficacy and incidence of adverse reactions of the two groups were compared.  Results  The incidence of severe apnea, extubation failure rate and non-invasive ventilation time in the observation group were 6.3% (3/48), 8.3% (4/48) and (4.34±1.74) days, respectively, which were significantly lower than those in the control group [20.8% (10/48), 22.9% (11/48) and (5.27±2.46) days], and the differences were statistically significant (all P < 0.05). The duration of invasive ventilation, oxygen inhalation time, the time to reach the whole intestinal feeding and the hospital stay in the observation group were 5.0(2.0, 7.0) days, 8.5(6.0, 12.5) days, (14.92±5.61) days, 18(14.3, 28.0) days, respectively, and there was no significant difference between the observation group and the control group [4.5(2.0, 7.0) days, 8.0(6.0, 17.8) days, (16.67±5.96) days, 17.5(15.0, 23.8) days], all P>0.05. There was no significant difference in the incidence of adverse reactions such as intraventricular hemorrhage (IVH), feeding intolerance, neonatal necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP) and tachycardia between the two groups (all P>0.05).  Conclusion  NIPPV combined with caffeine citrate can reduce the incidence of severe apnea, extubation failure rate and non-invasive ventilation time without increasing the incidence of adverse reactions, which is a safe and effective treatment for AOP.

     

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