Volume 21 Issue 4
Apr.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(4): 650-654
FENG Hongyan, TU Ning, WANG Ke, XIAO Xiong, WANG Chao, BU Lihong. Value of PET/CT on diagnosis and staging of primary bone lymphoma[J]. Chinese Journal of General Practice, 2023, 21(4): 650-654. doi: 10.16766/j.cnki.issn.1674-4152.002952
Citation: FENG Hongyan, TU Ning, WANG Ke, XIAO Xiong, WANG Chao, BU Lihong. Value of PET/CT on diagnosis and staging of primary bone lymphoma[J]. Chinese Journal of General Practice, 2023, 21(4): 650-654. doi: 10.16766/j.cnki.issn.1674-4152.002952
shu

Value of PET/CT on diagnosis and staging of primary bone lymphoma

doi: 10.16766/j.cnki.issn.1674-4152.002952

  • PET Center, Molecular Imaging Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China

Funds:

 81701735

  • Received Date: 2022-11-30
    Available Online: 2023-05-31
    Abstract
  •   Objective  Primary bone lymphoma (PBL) is a rare type of malignant lymphoma. This study mainly analyzes the 18F-FDG PET/CT imaging signs of PBL in order to improve the accuracy of the diagnosis and differential diagnosis of PBL, and conduct accurate staging to guide accurate clinical treatment.  Methods  A total of 10 patients with untreated PBL were retrospectively enrolled from March 2018 to October 2020 in PET Center of People ' s Hospital of Wuhan University. We analyzed the PET/CT, MRI characteristic and clinical data of PBL patients. There were 7 males and 3 females. The range of age was 29-73 years old with the median age of 46.0±7.4. Ten patients underwent PET/CT examination and 8 patients underwent MRI scanning. Using bone biopsy results as gold standard, the sites of bone infiltration and the detection rates of the PET/CT and MRI were analyzed.  Results  The main clinical symptoms of PBL patients were bone pain at different locations. The types of pathology of patients all were non-Hodgkin ' s lymphoma, and diffuse large B cell lymphoma in 5 patients. The 18F-FDG PET/CT were high uptake in all of patients with SUVmax 2.7-17.5 (10.2±5.2). Multiple involved lesions were found in 8 patients, while 2 patients presented with a single involved lesion. Four patients were found to be located in extremity skeleton, 2 in the axial skeleton and 4 in the extremity skeleton and axial skeleton. PET/CT also found the lesions infiltrate to the surrounding soft tissue in 6 patients. MRI images lack specificity, the focus showed iso-intensity or low signal on T1WI and slightly high or high signal on T2WI, and enhanced scan showed moderate enhancement. The detection rate of the PET/CT and MRI for PBL were 94.5% and 89.1%, respectively.  Conclusion  18F-FDG PET/CT has the ability to depict bone lesions, and upper draining lymph nodes and extra-nodal involvement. It has good clinical application value for diagnosis and staging of PBL.

     

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