Volume 21 Issue 4
Apr.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(4): 667-671
ZHONG Juanping, ZHANG Lihong, XIE Qi, MA Li, SU Yujie, WANG Xinglei, DOU Xinman. Research progress of capsaicin in patients with dysphagia[J]. Chinese Journal of General Practice, 2023, 21(4): 667-671. doi: 10.16766/j.cnki.issn.1674-4152.002956
Citation: ZHONG Juanping, ZHANG Lihong, XIE Qi, MA Li, SU Yujie, WANG Xinglei, DOU Xinman. Research progress of capsaicin in patients with dysphagia[J]. Chinese Journal of General Practice, 2023, 21(4): 667-671. doi: 10.16766/j.cnki.issn.1674-4152.002956
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Research progress of capsaicin in patients with dysphagia

doi: 10.16766/j.cnki.issn.1674-4152.002956
  • 1.

    School of Nursing, Lanzhou University, Lanzhou, Gansu 730000, China

Funds:

 CY2020-MS19

  • Received Date: 2022-04-26
    Available Online: 2023-05-31
    Abstract
  • Swallowing is an important function to maintain survival, and dysphagia has a high incidence amongst the elderly patients with nervous system diseases, oropharynx diseases, oesophageal diseases and mental diseases. When swallowing causes functional damage, patients often show symptoms such as difficulty in swallowing food, coughing in drinking water and salivation. Serious complications such as lung infection, dehydration, malnutrition, aspiration pneumonia and asphyxia can also occur. Consequently, leading to increased medical expenses, reduced satisfaction, and decreased quality of life for patients. Improving dysphagia aims to accelerate the recovery of swallowing and reducing the above-mentioned risks. At present, the treatment of dysphagia includes drug therapy and rehabilitation physiotherapy, but the compensatory measures of dysphagia and rehabilitation therapy technology have limited effects in improving the neurophysiology and biochemistry of swallowing function. In addition, no specific drug has been developed for the treatment of dysphagia. Capsaicin, as a new treatment method, is widely used in food, and it has low-cost and easy to extract. It has also been applied to patients with dysphagia by scholars at home and abroad, and the therapeutic effect is remarkable. Transient receptor potential vanilloid 1 (TRPV1), as a capsaicin receptor, is an extensive and popular receptor in non-selective cation channels. Capsaicin stimulation can cause swallowing reflex and cough reflex in patients, which makes swallowing process safer and more effective, thereby improving swallowing function and preventing inhalation pneumonia. In this paper, the overview of capsaicin, the mechanism of capsaicin used in patients with dysphagia, the intervention methods and the present situation, understanding and application potential of capsaicin in different patients with dysphagia were reviewed, to provide some theoretical basis and reference value for functional recovery of patients with dysphagia in the future.

     

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  • [1]
    ZUERCHER P, DZIEWAS R, SCHEFOLD J C. Dysphagia in critical care: focus on therapeutical interventions[J]. Intensive Care Med, 2020, 46(10): 1972-1973. doi: 10.1007/s00134-020-06189-x
    [2]
    SOUZA J T, RIBEIRO P W, DE PAIVA S A R, et al. Dysphagia and tube feeding after stroke are associated with poorer functional and mortality outcomes[J]. Clin Nutr, 2020, 39(9): 2786-2792. doi: 10.1016/j.clnu.2019.11.042
    [3]
    LÓPEZ-LIRIA R, PARRA-EGEDA J, VEGA-RAMÍREZ F A, et al. Treatment of dysphagia in Parkinson ' s disease: a systematic review[J]. Int J Environ Res Public Health, 2020, 17(11): 4104. doi: 10.3390/ijerph17114104
    [4]
    CHEN S, CUI Y, DING Y P, et al. Prevalence and risk factors of dysphagia among nursing home residents in eastern China: a cross-sectional study[J]. BMC Geriatr, 2020, 20(1): 352. doi: 10.1186/s12877-020-01752-z
    [5]
    THIYAGALINGAM S, KULINSKI A E, THORSTEINSDOTTIR B, et al. Dysphagia in older adults[J]. Mayo Clin Proc, 2021, 96(2): 488-497. doi: 10.1016/j.mayocp.2020.08.001
    [6]
    ESPINOSA-VAL M C, MARTÍN-MARTÍNEZ A, GRAUPERA M, et al. Prevalence, risk factors, and complications of oropharyngeal dysphagia in older patients with dementia[J]. Nutrients, 2020, 12(3): 863. doi: 10.3390/nu12030863
    [7]
    房雅娜, 宋桂芹, 李欣. 探讨高频重复经颅磁刺激与电刺激治疗脑卒中患者吞咽障碍的疗效观察[J]. 河北医学, 2020, 26(3): 421-424. https://www.cnki.com.cn/Article/CJFDTOTAL-HCYX202003017.htm

    FANG Y N, SONG G Q, LI X. Exploring the Therapeutic Effect of High Frequency Repetitive Transcranial Magnetic Stimulation and Electrical Stimulation on Dysphagia in Stroke Patients[J]. Hebei Medicine, 2020, 26(3): 421-424. https://www.cnki.com.cn/Article/CJFDTOTAL-HCYX202003017.htm
    [8]
    江方辉, 应忠明, 施玲玲. 揿针埋针联合吞咽康复训练治疗脑卒中后吞咽障碍的效果观察[J]. 中华全科医学, 2021, 19(3): 483-485. doi: 10.16766/j.cnki.issn.1674-4152.001841

    JIANG F H, YING Z M, SHI L L. Observation on the effect of pressing needle embedding acupuncture point combined with swallowing rehabilitation training on dysphagia after stroke[J]. Chinese Journal of General Practice, 2021, 19(3): 483-485. doi: 10.16766/j.cnki.issn.1674-4152.001841
    [9]
    PATOWARY P, PATHAK M P, ZAMAN K, et al. Research progress of capsaicin responses to various pharmacological challenges[J]. Biomed Pharmacother, 2017, 96(10): 1501-1512.
    [10]
    吴玲玲. 辣椒素刺激对脑卒中患者口咽期吞咽障碍影响的临床研究[D]. 苏州: 苏州大学, 2018.

    WU L L. Clinical study on the effect of capsaicin stimulation on dysphagia of stroke patients in oropharyngeal stage[D]. Suzhou: Soochow University, 2018.
    [11]
    TSUJI K, TSUJIMURA T, SAKAI S, et al. Involvement of capsaicin-sensitive nerves in the initiation of swallowing evoked by carbonated water in anesthetized rats[J]. Am J Physiol Gastrointest Liver Physiol, 2020, 319(5): G564-G572. doi: 10.1152/ajpgi.00233.2020
    [12]
    KANG C, WANG B, KALIANNAN K, et al. Gut microbiota mediates the protective effects of dietary capsaicin against chronic low-grade inflammation and associated obesity induced by high-fat diet[J]. mBio, 2017, 8(3): e00470-17. DOI: 10.1128/mBio.00470-17.
    [13]
    GONCALVES D, REBELO V, BARBOSA P, et al. 8% Capsaicin patch in treatment of peripheral neuropathic pain[J]. Pain Physician, 2020, 23(5): E541-E548. http://pubmed.ncbi.nlm.nih.gov/32967405/
    [14]
    POPESCU G D A, SCHEAU C, BADARAU I A, et al. The effects of capsaicin on gastrointestinal cancers[J]. Molecules, 2020, 26(1): 94. doi: 10.3390/molecules26010094
    [15]
    AGHAZADEH TABRIZI M, BARALDI P G, BARALDI S, et al. Medicinal chemistry, pharmacology, and clinical implications of TRPV1 receptor antagonists[J]. Med Res Rev, 2017, 37(4): 936-983. doi: 10.1002/med.21427
    [16]
    BRAGA FERREIRA L G, FARIA J V, DOS SANTOS J P S, et al. Capsaicin: TRPV1-independent mechanisms and novel therapeutic possibilities[J]. Eur J Pharmacol, 2020, 887(10): 173356. DOI: 10.1016/j.ejphar.2020.173356.
    [17]
    HOSSAIN M Z, ANDO H, UNNO S, et al. Activation of TRPV1 and TRPM8 channels in the larynx and associated laryngopharyngeal regions facilitates the swallowing reflex[J]. Int J Mol Sci, 2018, 19(12): 4113. doi: 10.3390/ijms19124113
    [18]
    YOSHIHARA M, TSUJIMURA T, SUZUKI T, et al. Sustained laryngeal transient receptor potential vanilloid 1 activation inhibits mechanically induced swallowing in anesthetized rats[J]. Am J Physiol Gastrointest Liver Physiol, 2020, 319(3): G412-G419. doi: 10.1152/ajpgi.00082.2020
    [19]
    NAKATO R, MANABE N, HANAYAMA K, et al. Diagnosis and treatments for oropharyngeal dysphagia: effects of capsaicin evaluated by newly developed ultrasonographic method[J]. J Smooth Muscle Res, 2020, 56: 46-57. doi: 10.1540/jsmr.56.46
    [20]
    KLETZIEN H, CULLINS M J, CONNOR N P. Age-related alterations in swallowing biomechanics[J]. Exp Gerontol, 2019, 118: 45-50. doi: 10.1016/j.exger.2019.01.006
    [21]
    SUNATA K, TERAI H, SEKI H, et al. Analysis of clinical outcomes in elderly patients with impaired swallowing function[J]. PLoS One, 2020, 15(9): e0239440. DOI: 10.1371/journal.pone.0239440.
    [22]
    PANEBIANCO M, MARCHESE-RAGONA R, MASIERO S, et al. Dysphagia in neurological diseases: a literature review[J]. Neurol Sci, 2020, 41(11): 3067-3073. doi: 10.1007/s10072-020-04495-2
    [23]
    WILKINSON J M, CODIPILLY D C, WILFAHRT R P. Dysphagia: evaluation and collaborative management[J]. Am Fam Physician, 2021, 103(2): 97-106.
    [24]
    OHNISHI H, JINNOUCHI O, AGAWA S, et al. Daily auricular stimulation with capsaicin ointment improved cough reflex sensitivity in elderly patients with dysphagia: a pilot study[J]. Acta Oto-Laryngologica, 2020, 140(3): 249-253. doi: 10.1080/00016489.2020.1716993
    [25]
    NAKATO R, MANABE N, SHIMIZU S, et al. Effects of capsaicin on older patients with oropharyngeal dysphagia: a double-blind, placebo-controlled, crossover study[J]. Digestion, 2017, 95(3): 210-220. doi: 10.1159/000463382
    [26]
    SUNTRUP-KRUEGER S, MUHLE P, KAMPE I, et al. Effect of capsaicinoids on neurophysiological, biochemical, and mechanical parameters of swallowing function[J]. Neurotherapeutics, 2021, DOI: 10.1007/s13311-020-00996-2.
    [27]
    DE COCK E, BATENS K, HEMELSOET D, et al. Dysphagia, dysarthria and aphasia following a first acute ischaemic stroke: incidence and associated factors[J]. Eur J Neurol, 2020, 27(10): 2014-2021. doi: 10.1111/ene.14385
    [28]
    ROFES L, ORTEGA O, VILARDELL N, et al. Spatiotemporal characteristics of the pharyngeal event-related potential in healthy subjects and older patients with oropharyngeal dysfunction[J]. Neurogastroenterol Motil, 2017, 29(2): 1296. doi: 10.1111/nmo.12916/abstract
    [29]
    KONDO E, JINNOUCHI O, OHNISHI H, et al. Aural stimulation with capsaicin ointment improved the swallowing function in patients with dysphagia: evaluation by the SMRC scale [J]. Nihon Jibiinkoka Gakkai Kaiho, 2015, 118(11): 1319-1326. doi: 10.3950/jibiinkoka.118.1319
    [30]
    WANG Z, WU L, FANG Q, et al. Effects of capsaicin on swallowing function in stroke patients with dysphagia: a randomized controlled trial[J]. J Stroke Cerebrovasc Dis, 2019, 28(6): 1744-1751. doi: 10.1016/j.jstrokecerebrovasdis.2019.02.008
    [31]
    ALVAREZ-BERDUGO D, ROFES L, ARREOLA V, et al. A comparative study on the therapeutic effect of TRPV1, TRPA1, and TRPM8 agonists on swallowing dysfunction associated with aging and neurological diseases[J]. Neurogastroenterol Motil, 2018, 30(2): 13185. DOI: 10.1111/nmo.13185.
    [32]
    TOMSEN N, ORTEGA O, ROFES L, et al. Acute and subacute effects of oropharyngeal sensory stimulation with TRPV1 agonists in older patients with oropharyngeal dysphagia: a biomechanical and neurophysiological randomized pilot study[J]. Therap Adv Gastroenterol, 2019, 12: 1-13. http://pubmed.ncbi.nlm.nih.gov/31068978/
    [33]
    KONDO E, JINNOUCHI O, NAKANO S, et al. Aural stimulation with capsaicin ointment improved swallowing function in elderly patients with dysphagia: a randomized, placebo-controlled, double-blind, comparative study[J]. Clin Interv Aging, 2017, 12: 1921-1928. doi: 10.2147/CIA.S138357
    [34]
    WIRTH R, DZIEWAS R. Dysphagia and pharmacotherapy in older adults[J]. Curr Opin Clin Nutr Metab Care, 2019, 22(1): 25-29. doi: 10.1097/MCO.0000000000000523
    [35]
    KITTIPANYA-NGAM P, BENJAPORNLERT P, RATTANAKANOKCHAI S, et al. Effect of TRP-Stimulating compounds to reduce swallowing response time in the elderly: a systematic review[J]. Dysphagia, 2021, 36(4): 614-622. doi: 10.1007/s00455-020-10175-2
    [36]
    JONES C A, COLLETTI C M, DING M C. Post-stroke dysphagia: recent insights and unanswered questions[J]. Curr Neurol Neurosci Rep, 2020, 20(12): 61. doi: 10.1007/s11910-020-01081-z
    [37]
    WANG Z, WU L L, FANG Q, et al. Effects of capsaicin on swallowing function in stroke patients with dysphagia: a randomized controlled trial[J]. J Stroke Cerebrovasc Dis, 2019, 28(6): 1744-1751. doi: 10.1016/j.jstrokecerebrovasdis.2019.02.008
    [38]
    CUI F F, YIN Q M, WU C, et al. Capsaicin combined with ice stimulation improves swallowing function in patients with dysphagia after stroke: a randomised controlled trial[J]. J Oral Rehabil, 2020, 47(10): 1297-1303. doi: 10.1111/joor.13068
    [39]
    曹猛. 天然辣椒素食团在急性缺血性脑卒中后吞咽障碍患者中的应用效果研究[D]. 广州: 南方医科大学, 2020.

    CAO M. Study on the application effect of natural chili vegetarian Ball in patients with dysphagia after acute ischemic stroke[D]. Guangzhou: Southern Medical University, 2020.
    [40]
    NASCIMENTO W, TOMSEN N, ACEDO S, et al. Effect of aging, gender and sensory stimulation of TRPV1 receptors with capsaicin on spontaneous swallowing frequency in patients with oropharyngeal dysphagia: a proof-of-concept study[J]. Diagnostics (Basel), 2021, 11(3): 461. doi: 10.3390/diagnostics11030461
    [41]
    CABIB C, NASCIMENTO W, ROFES L, et al. Short-term neurophysiological effects of sensory pathway neurorehabilitation strategies on chronic poststroke oropharyngeal dysphagia[J]. Neurogastroenterol Motil, 2020, 32(9): e13887. DOI: 10.1111/nmo.13887.
    [42]
    SCHRÖDER J B, MARIAN T, CLAUS I, et al. Substance P saliva reduction predicts pharyngeal dysphagia in Parkinson ' s disease[J]. Front Neurol, 2019, 10: 386. doi: 10.3389/fneur.2019.00386
    [43]
    UMEMOTO G, FURUYA H. Management of dysphagia in patients with Parkinson ' s disease and related disorders[J]. Intern Med, 2020, 59(1): 7-14. doi: 10.2169/internalmedicine.2373-18
    [44]
    JINNOUCHI O, OHNISHI H, KONDO E, et al. Aural stimulation with capsaicin prevented pneumonia in dementia patients[J]. Auris Nasus Larynx, 2020, 47(1): 154-157. doi: 10.1016/j.anl.2019.06.008
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