Effect of <i>Jieyu Qingxin Anshen</i> Decoction on adverse emotion and quality of life scale score in patients with depression

WANG Jiangang; YAN Huanni; ZHANG Ke; LIU Panmiao

doi:10.16766/j.cnki.issn.1674-4152.002959

Volume 21 Issue 4

Apr. 2023

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Article Navigation > Chinese Journal of General Practice > 2023 > 21(4): 681-684

WANG Jiangang, YAN Huanni, ZHANG Ke, LIU Panmiao. Effect of Jieyu Qingxin Anshen Decoction on adverse emotion and quality of life scale score in patients with depression[J]. Chinese Journal of General Practice, 2023, 21(4): 681-684. doi: 10.16766/j.cnki.issn.1674-4152.002959

Citation:

WANG Jiangang, YAN Huanni, ZHANG Ke, LIU Panmiao. Effect of Jieyu Qingxin Anshen Decoction on adverse emotion and quality of life scale score in patients with depression[J]. Chinese Journal of General Practice, 2023, 21(4): 681-684. doi: 10.16766/j.cnki.issn.1674-4152.002959

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Effect of Jieyu Qingxin Anshen Decoction on adverse emotion and quality of life scale score in patients with depression

doi: 10.16766/j.cnki.issn.1674-4152.002959

1.
Department of Psychiatry, the Sixth People' s Hospital, Zhoukou, Henan 466000, China

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LHGJ20200295

Received Date: 2022-06-01
Available Online: 2023-05-31

Abstract

Abstract

Objective To explore the effect of Jieyu Qingxin Anshen Decoction in the treatment of depression and its effect on the generation of adverse emotion and the score of quality of life scale (QOL). Methods A total of 120 patients with depression collected in the Psychiatric Department of the Sixth People ' s Hospital of Zhoukou City, Henan Province from October 2019 to October 2021 were divided into regular group and study group according to the random number table method, with 60 cases in each group. The patients in the regular group were treated with venlafaxine hydrochloride sustained-release tablets, and the patients in the study group were treated with Jieyu Qingxin Anshen Decoction on the basis of the regular group. After 2 months of treatment, the clinical efficacy, the level of regulating hormone of thalamus adrenal pituitary axis (HPA) axis, brain-derived neurotrophic factor (BDNF), serum high-sensitivity C-reactive protein (hs-CRP) and uric acid (UA), adverse emotion, quality of life and adverse reactions were compared between the two groups. Results Compared with the regular group, the total effective rate (91.67% vs. 78.33%) in the study group was significantly higher, while the incidence of adverse reactions (3.33% vs. 13.33%) and adverse reaction symptoms scale (TESS) score [(2.57±1.42) points vs. (4.78±1.47) points] were significantly lower (all P < 0.05). Compared with before treatment, the levels of serum cortisol (COR), adrenocortical hormones (ACTH), hs-CRP, 17-item Hamilton depression scale (HAMD-17) score and Hamilton anxiety scale (HAMA) score in the two groups decreased significantly after treatment, while the levels of serum BDNF, UA and QOL score increased significantly (all P < 0.05), and the change range of the above indexes in the study group were significantly greater than that in the regular group (all P < 0.05). Conclusion Jieyu Qingxin Anshen Decoction can improve the adverse emotion and quality of life of patients with depression, with significant therapeutic effect and high safety.
- Depression,
- Jieyu Qingxin Anshen Decoction,
- Adverse emotion,
- Quality of life score

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References(23)

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Effect of Jieyu Qingxin Anshen Decoction on adverse emotion and quality of life scale score in patients with depression

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