Volume 21 Issue 5
May  2023
Turn off MathJax
Article Contents
Expert consensus on the diagnosis and treatment of novel coronavirus infection in neonates[J]. Chinese Journal of General Practice, 2023, 21(5): 726-731. doi: 10.16766/j.cnki.issn.1674-4152.002969
Citation: Expert consensus on the diagnosis and treatment of novel coronavirus infection in neonates[J]. Chinese Journal of General Practice, 2023, 21(5): 726-731. doi: 10.16766/j.cnki.issn.1674-4152.002969

Expert consensus on the diagnosis and treatment of novel coronavirus infection in neonates

doi: 10.16766/j.cnki.issn.1674-4152.002969
  • Received Date: 2023-02-03
  • Novel coronavirus infection has been raging globally for more than three years. With limited reports of neonatal cases of novel coronavirus infection at home and abroad, and little experience in clinical diagnosis and treatment, many problems will inevitably arise in the process of diagnosis and treatment, posing great challenges and pressure to medical staff in the neonatology department. In order to further standardize the diagnosis and treatment of novel coronavirus infection in neonates, the Neonatal Evidence-Based Medicine Group, Commission of Neonatal Medicine, Cross-Straits Medicine Exchange Association, based on domestic and foreign clinical evidence and combined with clinical practice experience, the expert consensus was mainly developed from the etiology, clinical manifestations, laboratory examination, diagnosis, home isolation management, fever clinic visit management, treatment, complications and prognosis of neonatal infection with novel coronavirus.

     

  • loading
  • [1]
    LAI C C, SHIH T P, KO W C, et al. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges[J]. Int J Antimicrob Agents, 2020, 55(3): 105924. DOI: 10.1016/j.ijantimicag.2020.105924.
    [2]
    BOLY T J, REYES-HERNANDEZ M E, DANIELS E C, et al. Hyperglycemia and cytopeniasas signs of SARS-CoV-2 delta variant infection in preterm infants[J]. Pediatrics, 2022, 149(6): e2021055331. DOI: 10.1542/peds.2021-055331.
    [3]
    SANKARAN D, NAKRA N, CHEEMA R, et al. Perinatal SARS-CoV-2 infection and neonatal COVID-19: a 2021 Update[J]. Neoreviews, 2021, 22(5): e284-e295. doi: 10.1542/neo.22-5-e284
    [4]
    PIETRASANTA C, RONCHI A, SCHENA F, et al. SARS-CoV-2 infection and neonates: a review of evidence and unresolved questions[J]. Pediatr Allergy Immunol, 2020, 31Suppl 26: 79-81.
    [5]
    RASCHETTI R, VIVANTI A J, VAULOUP-FELLOUS C, et al. Synthesis and systematic review of reported neonatal SARS-CoV-2 infections[J]. Nat Commun, 2020, 11(1): 5164. DOI: 10.1038/s41467-020-18982-9.
    [6]
    LAINE L, SKÖN M, VǍISǍNEN E, et al. SARS-CoV-2 variants Alpha, Beta, Delta and Omicron show a slower host cell interferon response compared to an early pandemic variant[J]. Front Immunol, 2022, 13: 1016108. DOI: 10.3389/fimmu.2022.1016108.
    [7]
    ISTIFLI E S, NETZ P A, SIHOGLU TEPE A, et al. Understanding the molecular interaction of SARS-CoV-2 spike mutants with ACE2 (angiotensin converting enzyme 2)[J]. J Biomol Struct Dyn, 2022, 40(23): 12760-12771. doi: 10.1080/07391102.2021.1975569
    [8]
    ZHAO D, CHEN X, HAN D, et al. Pulmonary ACE2 expression in neonatal and adult rats[J]. FEBS Open Bio, 2021, 11(8): 2266-2272. doi: 10.1002/2211-5463.13232
    [9]
    GARCÍA H, ALLENDE-LÓPEZ A, MORALES-RUÍZ P, et al. COVID-19 in neonates with positive RT-PCR test. Systematic Review[J]. Arch Med Res, 2022, 53(3): 252-262. doi: 10.1016/j.arcmed.2022.03.001
    [10]
    AKIN I M, KANBUROGLU M K, TAVMAN C, et al. Epidemiologic and clinical characteristics of neonates with late-onset COVID-19: 1-year data of Turkish Neonatal Society[J]. Eur J Pediatr, 2022, 181(5): 1933-1942. doi: 10.1007/s00431-021-04358-8
    [11]
    ZENG L, XIA S, YUAN W, et al. Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China[J]. JAMA Pediatr, 2020, 174(7): 722-725. doi: 10.1001/jamapediatrics.2020.0878
    [12]
    GALE C, QUIGLEY M A, PLACZEK A, et al. Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance[J]. Lancet Child Adolesc Health, 2021, 5(2): 113-121. doi: 10.1016/S2352-4642(20)30342-4
    [13]
    须丽清, 曹清, 刘彪, 等. 新生儿社区获得性新型冠状病毒奥密克戎变异株感染7例临床分析[J]. 中华新生儿科杂志, 2022, 37(5): 413-417.

    PENG X Q, CAO Q, LIU B, et al. Clinical analysis of 7 cases of community-acquired Novel Coronavirus Omicron variant infection in neonates[J]. Chinese Journal of Neonatology, 2022, 37(5): 413-417.
    [14]
    张可, 蒋思远, 严恺, 等. 新型冠状病毒Omicron变异株流行期间新生儿感染16例临床特征分析[J]. 中华儿科杂志, 2022, 60(11): 1158-1162.

    ZHANG K, JIANG S Y, YAN K, et al. Clinical characteristics of 16 neonates infected with SARS-CoV-2 during Omicron variant outbreak[J]. Chinese Journal of Pediatrics, 2022, 60(11): 1158-1162.
    [15]
    曾凌空, 陶旭炜, 袁文浩, 等. 中国首例新生儿新型冠状病毒肺炎[J]. 中华儿科杂志, 2020, 58(4): 279-280. https://www.cnki.com.cn/Article/CJFDTOTAL-HNYF202104022.htm

    ZENG L K, TAO X W, YUAN W H, et al. First case of neonate with COVID-19 in China[J]. Chinese Journal of Pediatrics, 2020, 58(4): 279-280. https://www.cnki.com.cn/Article/CJFDTOTAL-HNYF202104022.htm
    [16]
    莫艳, 莫坚, 梁汝英, 等. 新生儿重型新型冠状病毒肺炎1例报告[J]. 中国当代儿科杂志, 2022, 24(11): 1266-1268. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ202211014.htm

    MO Y, MO J, LIANG R Y, et al. A case report of neonatal severe coronavirus disease 2019[J]. Chinese Journal of Contemporary Pediatrics, 2022, 24(11): 1266-1268. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ202211014.htm
    [17]
    王劲, 王丹, 陈国策, 等. 以消化道症状为首发表现的新生儿SARS-CoV-2感染1例[J]. 中国当代儿科杂志, 2020, 22(3): 211-214. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ202003007.htm

    WANG J, WANG D, CHEN G C, et al. SARS-CoV-2 infection with gastrointestinal symptoms as the first manifestation in a neonate[J]. Chinese Journal of Contemporary Pediatrics, 2020, 22(3): 211-214. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ202003007.htm
    [18]
    LIU C, MENDONCA L, YANG Y, et al. The Architecture of inactivated SARS-CoV-2 with postfusion spikes revealed by Cryo-EM and Cryo-ET[J]. Structure, 2020, 28(11): 1218-1224. e4. DOI: 10.1016/j.str.2020.10.001.
    [19]
    CORBISIER P, PETRILLO M, MARCHINI A, et al. A qualitative RT-PCR assay for the specific identification of the SARS-CoV-2 B. 1.1.529 (Omicron) Variant of Concern[J]. J Clin Virol, 2022, 152: 105191. DOI: 10.1016/j.jcv.2022.105191.
    [20]
    RANA R, KANT R, HUIREM R S, et al. Omicron variant: current insights and future directions[J]. Microbiol Res, 2022, 265: 127204. DOI: 10.1016/j.micres.2022.127204.
    [21]
    JUNGNICK S, HOBMAIER B, PARAVINIA N, et al. Analysis of seven SARS-CoV-2 rapid antigen tests in detecting omicron (B. 1.1.529) versus delta (B. 1.617.2) using cell culture supernatants and clinical specimens[J]. Infection, 2022, 20: 1-7.
    [22]
    MOLLURA M, SARTI R, LEVI R, et al. Antibody titer correlates with Omicron infection in vaccinated healthcare workers[J]. Viruses, 2022, 14(12): 2605. DOI: 10.3390/v14122605.
    [23]
    国家卫生健康委, 国家中医药局. 新型冠状病毒感染诊疗方案(试行第十版)[EB/OL]. (2023-01-07)[2023-01-25]. http://www.nhc.gov.cn/xcs/zhengcwj/202301/bdc1ff75feb94934ae1dade176d30936.shtml.

    State Health Commission, State Administration of Traditional Chinese Medicine. Diagnosis and Treatment of COVID-19(Trial Version 10)[EB/OL]. (2023-01-07)[2023-01-25]. http://www.nhc.gov.cn/xcs/zhengcwj/202301/bdc1ff75feb94934ae1dade176d30936.shtml.
    [24]
    蒋荣猛, 谢正德, 姜毅, 等. 儿童新型冠状病毒感染诊断、治疗和预防专家共识(第四版)[J]. 中华实用儿科临床杂志, 2022, 37(14): 1053-1065. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202003002.htm

    JIANG M R, XIE Z D, JIANG Y, et al. Diagnosis, treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children: experts'consensus statement(Fourth Edition)[J]. Chinese Journal of Applied Clinical Pediatrics, 2022, 37(14): 1053-1065. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYHS202003002.htm
    [25]
    DE CARVALHO W B, GIBELLⅡ M A B C, KREBS V L J, et al. Expert recommendations for the care of newborns of mothers with COVID-19[J]. Clinics (Sao Paulo), 2020, 75: e1932. DOI: 10.6061/clinics/2020/e1932.
    [26]
    YEO K T, BISWAS A, YING H O S K, et al. Guidance for the clinical management of infants born to mothers with suspected/confirmed COVID-19 in Singapore[J]. Singapore Med J, 2022, 63(9): 489-496.
    [27]
    KYLE M H, GLASSMAN M E, KHAN A, et al. A review of newborn outcomes during the COVID-19 pandemic[J]. Semin Perinatol, 2020, 44(7): 151286. DOI: 10.1016/j.semperi.2020.151286.
    [28]
    中华人民共和国国家卫生健康委员会. 新型冠状病毒实验室生物安全指南(第二版)[J]. 中国实用乡村医生杂志, 2020, 27(3): 4-5. https://www.cnki.com.cn/Article/CJFDTOTAL-LSXY202003001.htm

    National Health Commission of the People's Republic of China Laboratory Biosafety Guidelines for Novel Coronavirus (2nd Edition)[J]. Chinese Practical Journal Of Rural, 2020, 27(3): 4-5. https://www.cnki.com.cn/Article/CJFDTOTAL-LSXY202003001.htm
    [29]
    SHAMSODDIN E. A COVID-19 pandemic guideline in evidence-based medicine[J]. Evid Based Dent, 2020, 21(2): 71-73.
    [30]
    PAVLIDIS P, EDDY K, PHUNG L, et al. Clinical guidelines for caring for women with COVID-19 during pregnancy, childbirth and the immediate postpartum period[J]. Women Birth, 2021, 34(5): 455-464.
    [31]
    MA X, ZHU J, DU L. Neonatal management during the coronavirus disease (COVID-19) outbreak: the Chinese experience[J]. Neoreviews, 2020, 21(5): e293-e297.
    [32]
    中国当代儿科杂志编辑委员会, 围产新生儿新型冠状病毒感染防控管理预案工作组. 围产新生儿新型冠状病毒感染防控管理预案(第三版)[J]. 中国当代儿科杂志, 2023, 25(1): 1-4. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ202301001.htm

    Chinese Journal of Contemporary Pediatrics Editorial Board, Perinatal neonatal novel coronavirus Infection Prevention and control management plan working group. Perinatal and neonatal management plan for prevention and control of SARS-CoV-2 infection(3rd Edition)[J]. Chinese Journal of Contemporary Pediatrics, 2023, 25(1): 1-4. https://www.cnki.com.cn/Article/CJFDTOTAL-DDKZ202301001.htm
    [33]
    BARTOLETTI M, AZAP O, BARAC A, et al. ESCMID COVID-19 living guidelines: drug treatment and clinical management[J]. Clin Microbiol Infect, 2022, 28(2): 222-238.
    [34]
    American Academy of Pediatrics.FAQs: Management of infants born to mothers with suspected or confirmed COVID-19[EB/OL]. (2022-11-10)[2022-11-22]. https://www.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/clinical-guidance/faqs-management-of-infants-born-to-covid-19-mothers.
    [35]
    DE ROSE D U, PUGNALONI F, CALI M, et al. Multisystem inflammatory syndrome in neonates born to mothers with SARS-CoV-2 infection (MIS-N) and in neonates and infants younger than 6 months with acquired COVID-19 (MIS-C): a systematic review[J]. Viruses, 2022, 14(4): 750.
    [36]
    MORE K, AIVER S, GOTI A, et al. Multisystem inflammatory syndrome in neonates (MIS-N) associated with SARS-CoV2 infection: a case series[J]. Eur J Pediatr, 2022, 181(5): 1883-1898.
    [37]
    DEVIN J, MARANO R, MIKHAEL M, et al. Epidemiology of neonatal COVID-19 in the United States[J]. Pediatrics, 2022, 150(4): e2022056297. DOI: 10.1542/peds.2022-056297.
    [38]
    DE MORAES F M, DE SOUZA J W P S, ALVES L P, et al. SARS-CoV-2 infection and possible neonatal neurological outcomes: a literature review[J]. Viruses, 2022, 14(5): 1037. DOI: 10.3390/v14051037.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (211) PDF downloads(40) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return