Volume 21 Issue 5
May  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(5): 736-739
WANG Yanan, DAI Qianqian, RU Liang. The changes and clinical significance of serum Rac1 levels in children with bronchial asthma[J]. Chinese Journal of General Practice, 2023, 21(5): 736-739. doi: 10.16766/j.cnki.issn.1674-4152.002971
Citation: WANG Yanan, DAI Qianqian, RU Liang. The changes and clinical significance of serum Rac1 levels in children with bronchial asthma[J]. Chinese Journal of General Practice, 2023, 21(5): 736-739. doi: 10.16766/j.cnki.issn.1674-4152.002971
shu

The changes and clinical significance of serum Rac1 levels in children with bronchial asthma

doi: 10.16766/j.cnki.issn.1674-4152.002971

  • Department of Pediatrics of the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830000, China

Funds:

 2019D01C310

  • Received Date: 2022-11-17
    Abstract
  •   Objective  Through detecting the changes of serum Ras-related C3 botulinum toxin substrate 1 (Rac1) levels in children with bronchial asthma, the relationship between them and the severity and prognosis of the children ' s disease was investigated.  Methods  One hundred and fifty children with bronchial asthma admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2019 to January 2022 were selected as the observation group and divided into mild (49 cases), moderate (59 cases) and severe (42 cases) groups according to the severity of disease. Another 80 healthy children were selected as the control group. The Rac1 mRNA of serum monocyte cells was detected by RT-PCR. The correlation between Rac1 mRNA and the airway inflammatory response and lung function of the children was analyzed by Pearson, and the risk factors for the prognosis of children with bronchial asthma were analyzed by logistic regression.  Results  The Rac1 mRNA was lower in the mild (0.14±0.03), moderate (0.07±0.02) and severe (0.06±0.03) groups than that in the control group (0.16±0.03), t=3.675, 19.990, 17.493, all P < 0.05; Rac1 mRNA was significantly negatively correlated with IL-25, IL-33, fractional exhaled nitric oxide (FeNO), IgE (r=-0.620, -0.691, -0.660, -0.634, all P < 0.01) and positively correlated with the forced expiratory volume in one second (FEV1), FEV1/forced vital capacity (FVC), peak expiratory flow (PEF) in children with asthma (r=0.648, 0.582, 0.522, all P < 0.01). High level of Rac1 mRNA was a protective factor affecting the prognosis of children with asthma (OR=0.753, 95%CI: 0.647-0.877, P < 0.001).  Conclusion  Lower serum Rac1 levels in children with bronchial asthma are associated with airway inflammatory response and decreased lung function.

     

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