Volume 21 Issue 5
May  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(5): 740-743
ZHANG Guiying, HU Yang, HUANG Bo, GAO Hongliang, ZHU Mengsha. Correlation between abnormal expression of serum inflammatory factors and RNA in children with severe pneumonia and lung injury and treatment outcomes[J]. Chinese Journal of General Practice, 2023, 21(5): 740-743. doi: 10.16766/j.cnki.issn.1674-4152.002972
Citation: ZHANG Guiying, HU Yang, HUANG Bo, GAO Hongliang, ZHU Mengsha. Correlation between abnormal expression of serum inflammatory factors and RNA in children with severe pneumonia and lung injury and treatment outcomes[J]. Chinese Journal of General Practice, 2023, 21(5): 740-743. doi: 10.16766/j.cnki.issn.1674-4152.002972
shu

Correlation between abnormal expression of serum inflammatory factors and RNA in children with severe pneumonia and lung injury and treatment outcomes

doi: 10.16766/j.cnki.issn.1674-4152.002972

  • Second Department of Intensive Medicine, Hebei Children ' s Hospital, Shijiazhuang, Hebei 050031, China

Funds:

 20190848

  • Received Date: 2022-11-28
    Abstract
  •   Objective  To investigate the abnormal expression of serum inflammatory factors and RNA in children with severe pneumonia, and explore its effect on the lungs and treatment of children.  Methods  A total of 158 children with pneumonia admitted to Hebei Children ' s Hospital from August 2020 to August 2022 were selected as the study subjects, including 72 cases of severe pneumonia (severe group) and 86 cases of common pneumonia (general group). In addition, 80 healthy children who underwent physical examination in the hospital during the same period were selected as the control group. RNA levels, LPS scores, and serum inflammatory factor levels in each group were analyzed and compared, and the predictive value of serum procalcitonin (PCT) and RNA levels on lung and adverse outcomes was analyzed.  Results  The levels of miRNA-221 and miRNA-24 in the severe group, general group, and control group increased in turn, the LPS score decreased in turn, and the serum levels of PCT, PGRN, and CRP decreased in turn (all P < 0.05). In the treatment outcome of the severe group, the serum PCT level of the surviving children was lower than that of the dead children, while the levels of miRNA-221 and miRNA-24 were higher than those of the dead children (all P < 0.05). According to Pearson correlation analysis, there was a positive correlation between lung injury and treatment outcome in children with severe illness and serum PCT, but a negative correlation between them and levels of miRNA-221 and miRNA-24 (P < 0.05). Logistic regression analysis showed that high levels of serum PCT, low levels of miRNA-221 and miRNA-24 were independent risk factors for lung injury and adverse treatment outcomes in children with severe pneumonia (all P < 0.05). ROC curve analysis showed that the level of this factor had specificity for the risk of adverse disease outcomes, with sensitivities of 0.802, 0.807, 0.814 and 0.845, 0.850, 0.858, respectively, which had high predictive value (AUC>0.70).  Conclusion  The abnormal expression of serum PCT, miRNA-221 and miRNA-24 in children with severe pneumonia is closely related to the occurrence of lung injury and adverse treatment outcomes, and is an independent risk factor and has good predictive value.

     

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    • References(23)
  • [1]
    李玉华, 马兵, 胡莹莹, 等. 重症肺炎患儿血清颗粒蛋白前体, 血清淀粉样蛋白A水平变化及其与病情和预后的关系[J]. 山东医药, 2021, 61(16): 16-19. doi: 10.3969/j.issn.1002-266X.2021.16.004

    LI Y H, MA B, HU Y Y, et al. Changes of serum granuloprotein precursor and serum amyloid A levels in children with severe pneumonia and their relationship with illness and prognosis[J]. Shandong Medicine, 2021, 61(16): 16-19. doi: 10.3969/j.issn.1002-266X.2021.16.004
    [2]
    代丽. 清肺汤对重症肺炎患者血气及血清PCT CPR水平的影响[J]. 光明中医, 2022, 37(14): 2483-2485. doi: 10.3969/j.issn.1003-8914.2022.14.006

    DAI L. Effect of Daili Qingfei decoction on blood gas and serum PCCPR level in patients with severe pneumonia[J]. Guangming Traditional Chinese Medicine, 2022, 37(14): 2483-2485. doi: 10.3969/j.issn.1003-8914.2022.14.006
    [3]
    程涛. 重症肺炎患者预后与中性粒细胞/淋巴细胞比值、降钙素原水平的相关性分析[J]. 黑龙江医学, 2022, 46(14): 1675-1677. doi: 10.3969/j.issn.1004-5775.2022.14.003

    CHENG T. Correlation analysis between prognosis of patients with severe pneumonia and neutrophil/lymphocyte ratio and procalcitonin level[J]. Heilongjiang Medical, 2022, 46(14): 1675-1677. doi: 10.3969/j.issn.1004-5775.2022.14.003
    [4]
    魏腾陈, 余艳梅, 潘云虎, 等. 重症肺炎伴感染性休克行早期限制性液体复苏的治疗分析[J]. 中国卫生标准管理, 2022, 13(11): 101-104. https://www.cnki.com.cn/Article/CJFDTOTAL-WSBZ202211028.htm

    WEI T C, YU Y M, PAN Y H, et al. Analysis of early limited fluid resuscitation for severe pneumonia with septic shock[J]. China Health Standard Management, 2022, 13(11): 101-104. https://www.cnki.com.cn/Article/CJFDTOTAL-WSBZ202211028.htm
    [5]
    CHANG Q, CHEN H L, WU N S, et al. Prediction model for severe mycoplasma pneumoniae pneumonia in pediatric patients by admission laboratory indicators[J]. J Trop Pediatr, 2022, 68(4): fmac059. DOI: 10.1093/tropej/fmac059.
    [6]
    王海妮, 李爱玲. 重症肺炎患者血清降钙素原及炎症因子水平的变化及参考价值分析[J]. 贵州医药, 2022, 46(5): 794-795. doi: 10.3969/j.issn.1000-744X.2022.05.067

    WANG H N, LI A L. Changes and reference value analysis of serum procalcitonin and inflammatory factors in patients with severe pneumonia[J]. Guizhou Medicine, 2022, 46(5): 794-795. doi: 10.3969/j.issn.1000-744X.2022.05.067
    [7]
    刘湘园, 张婷, 周丽. 血清PCT、NLR联合胸部CT表现预测重症肺炎预后价值分析[J]. 中国实验诊断学, 2022, 26(5): 653-657. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSZD202205005.htm

    LIU X Y, ZHANG T, ZHOU L. Prognostic value of serum PCT, NLR combined with chest CT manifestations in severe pneumonia[J]. Chinese Journal of Laboratory Diagnosis, 2022, 26(5): 653-657. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSZD202205005.htm
    [8]
    张嘉宾, 刘聪辉, 付爱双, 等. PCT、APTT联合PSI评分对老年CAP严重程度评估及预测预后的价值[J]. 华北理工大学学报(医学版), 2022, 24(3): 204-208, 216. https://www.cnki.com.cn/Article/CJFDTOTAL-MTYX202203007.htm

    ZHANG J B, LIU C H, FU A S, et al. The value of PCT, APTT combined with PSI in evaluating the severity of CAP in the elderly and predicting the prognosis[J]. Journal of North China University of Science and Technology (Medical Edition), 2022, 24(3): 204-208, 216. https://www.cnki.com.cn/Article/CJFDTOTAL-MTYX202203007.htm
    [9]
    万磊, 杨灵杰, 孟庆欣, 等. 超声诊断重症肺炎的临床价值[J]. 东南国防医药, 2022, 24(3): 253-256. https://www.cnki.com.cn/Article/CJFDTOTAL-DNGY202203006.htm

    WAN L, YANG L J, MENG Q X, et al. Clinical value of ultrasound in the diagnosis of severe pneumonia[J]. Southeast National Defense Medicine, 2022, 24(3): 253-256. https://www.cnki.com.cn/Article/CJFDTOTAL-DNGY202203006.htm
    [10]
    童燕燕, 刘巨方, 马静, 等. 肺部超声联合降钙素原检测对重症肺炎和非重症肺炎鉴别诊断的临床价值[J]. 中国医药导刊, 2022, 24(4): 375-379. https://www.cnki.com.cn/Article/CJFDTOTAL-DKYY202204009.htm
    [11]
    张燕. 重症肺炎患者血清乳酸清除率、降钙素原清除率与预后的关系分析[J]. 淮海医药, 2022, 40(2): 184-187. https://www.cnki.com.cn/Article/CJFDTOTAL-HHYY202202021.htm

    ZHANG Y. Analysis of the relationship between serum lactate clearance rate, procalcitonin clearance rate and prognosis in patients with severe pneumonia[J]. Journal of Huaihai Medicine, 2022, 40(2): 184-187. https://www.cnki.com.cn/Article/CJFDTOTAL-HHYY202202021.htm
    [12]
    SHAHRIN L, CHISTI M J, SARMIN M, et al. Intravenous amoxicillin plus intravenous gentamicin for children with severe pneumonia in Bangladesh: an open-label, randomized, non-inferiority controlled trial[J]. Life, 2021, 11(12): 1299.
    [13]
    HUQ KATME, MORIYAMA M, MATSUYAMA R, et al. Association of socio-demographic and climatic factors with the duration of hospital stay of under-five children with severe pneumonia in urban bangladesh: an observational study[J]. Children (Basel), 2021, 8(11): 1036.
    [14]
    梁卓信, 张森雄, 韩咏. 儿童重症肺炎合并心肌损伤的危险因素分析及模型构建[J]. 临床肺科杂志, 2021, 26(7): 984-987, 992. https://www.cnki.com.cn/Article/CJFDTOTAL-LCFK202107004.htm

    LIANG Z X, ZHANG S X, HAN Y. Risk factors analysis and model construction of severe pneumonia complicated with myocardial injury in children[J]. Journal of Clinical Pulmonary Science, 2021, 26(7): 984-987, 992. https://www.cnki.com.cn/Article/CJFDTOTAL-LCFK202107004.htm
    [15]
    余菲菲, 朱晓萍, 龙梅, 等. 血清suPAR、PCT、CRP水平在小儿重症肺炎鉴别诊断中的效能分析[J]. 现代生物医学进展, 2021, 21(21): 4104-4107, 4099. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX202121022.htm

    YU F F, ZHU X P, LONG M, et al. Efficacy analysis of serum suPAR, PCT and CRP levels in differential diagnosis of severe pneumonia in children[J]. Advances in Modern Biomedicine, 2021, 21(21): 4104-4107, 4099. https://www.cnki.com.cn/Article/CJFDTOTAL-SWCX202121022.htm
    [16]
    MIR F, ALI NATHWANI A, CHANAR S, et al. Impact of pulse oximetry o n hospital referral acceptance in children under 5 with severe pneumonia in rural Pakistan (district Jamshoro): protocol for a cluster randomised trial[J]. BMJ Open, 2021, 11(9): e046158. DOI: 10.1136/BMJOPEN-2020-046158.
    [17]
    荆梦君. 血清PCT、IL-6检验在重症肺炎诊断中的应用价值分析[J]. 中国卫生标准管理, 2021, 12(21): 33-35. https://www.cnki.com.cn/Article/CJFDTOTAL-WSBZ202121012.htm

    JING M J. analysis of the application value of serum PCT and IL-6 test in the diagnosis of severe pneumonia[J]. China health standard management, 2021, 12(21): 33-35. https://www.cnki.com.cn/Article/CJFDTOTAL-WSBZ202121012.htm
    [18]
    LI M Y, CHEN Y, LI H H, et al. Serum CXCL10/IP-10 may be a potential biomarker for severe Mycoplasma pneumoniae pneumonia in children[J]. BMC Infect Dise, 2021, 21(1): 909.
    [19]
    HUQ K A T M E, MORIYAMA M, MATSUYAMA R, et al. Clinical characteristics and underlying factors related to recovery from severe pneumonia in under-five children with or without malnutrition treated at health care facilities in Bangladesh[J]. Children (Basel), 2021, 8(9): 778.
    [20]
    BUNTHI C, RHODES J, THAMTHITIWAT S, et al. Etiology and clinical characteristics of severe pneumonia among young children in Thailand: pneumonia etiology research for child health (PERCH) case-control study findings, 2012-2013[J]. Pediatr Infect Dis J, 2021, 40(9S): S91-S100.
    [21]
    徐静, 黄光举, 李娟, 等. 人免疫球蛋白联合利奈唑胺对儿童重症肺炎血清IL-1R1及APC的影响[J]. 武警后勤学院学报(医学版), 2021, 30(7): 99-100. https://www.cnki.com.cn/Article/CJFDTOTAL-WUXB202107036.htm

    XU J, HUANG GJ, LI J, et al. Effects of human immunoglobulin combined with linezolid on serum IL-1R1 and APC in children with severe pneumonia[J]. Journal of Logistics University of Capf (Medical Edition), 2021, 30(7): 99-100. https://www.cnki.com.cn/Article/CJFDTOTAL-WUXB202107036.htm
    [22]
    潘蕾, 毛敏杰, 黄晓庆, 等. 利奈唑胺治疗肺结核合并重症肺炎的疗效及对患者免疫因子和预后的影响[J]. 中华全科医学, 2019, 17(1): 47-51. doi: 10.16766/j.cnki.issn.1674-4152.000596

    PAN L, MAO M J, HUANG X Q, et al. The efficacy of linezolid in the treatment of pulmonary tuberculosis complicated with severe pneumonia and its influence on immune factors and prognosis[J]. Chinese General Medicine, 2019, 17(1): 47-51. doi: 10.16766/j.cnki.issn.1674-4152.000596
    [23]
    何荣琦, 许荣誉. 非小细胞肺癌患者肺组织中miRNA-155和miRNA-221的表达情况及其与预后的相关性[J]. 中国慢性病预防与控制, 2020, 28(1): 57-60. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMXB202001015.htm

    HE R Q, XU R Y. Expression of miRNA-155 and miRNA-221 in lung tissue of patients with non-small cell lung cancer and their correlation with prognosis[J]. China Chronic Disease Prevention and Control, 2020, 28(1): 57-60. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMXB202001015.htm
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