Volume 21 Issue 5
May  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(5): 740-743
ZHANG Guiying, HU Yang, HUANG Bo, GAO Hongliang, ZHU Mengsha. Correlation between abnormal expression of serum inflammatory factors and RNA in children with severe pneumonia and lung injury and treatment outcomes[J]. Chinese Journal of General Practice, 2023, 21(5): 740-743. doi: 10.16766/j.cnki.issn.1674-4152.002972
Citation: ZHANG Guiying, HU Yang, HUANG Bo, GAO Hongliang, ZHU Mengsha. Correlation between abnormal expression of serum inflammatory factors and RNA in children with severe pneumonia and lung injury and treatment outcomes[J]. Chinese Journal of General Practice, 2023, 21(5): 740-743. doi: 10.16766/j.cnki.issn.1674-4152.002972
shu

Correlation between abnormal expression of serum inflammatory factors and RNA in children with severe pneumonia and lung injury and treatment outcomes

doi: 10.16766/j.cnki.issn.1674-4152.002972

  • Second Department of Intensive Medicine, Hebei Children ' s Hospital, Shijiazhuang, Hebei 050031, China

Funds:

 20190848

  • Received Date: 2022-11-28
    Abstract
  •   Objective  To investigate the abnormal expression of serum inflammatory factors and RNA in children with severe pneumonia, and explore its effect on the lungs and treatment of children.  Methods  A total of 158 children with pneumonia admitted to Hebei Children ' s Hospital from August 2020 to August 2022 were selected as the study subjects, including 72 cases of severe pneumonia (severe group) and 86 cases of common pneumonia (general group). In addition, 80 healthy children who underwent physical examination in the hospital during the same period were selected as the control group. RNA levels, LPS scores, and serum inflammatory factor levels in each group were analyzed and compared, and the predictive value of serum procalcitonin (PCT) and RNA levels on lung and adverse outcomes was analyzed.  Results  The levels of miRNA-221 and miRNA-24 in the severe group, general group, and control group increased in turn, the LPS score decreased in turn, and the serum levels of PCT, PGRN, and CRP decreased in turn (all P < 0.05). In the treatment outcome of the severe group, the serum PCT level of the surviving children was lower than that of the dead children, while the levels of miRNA-221 and miRNA-24 were higher than those of the dead children (all P < 0.05). According to Pearson correlation analysis, there was a positive correlation between lung injury and treatment outcome in children with severe illness and serum PCT, but a negative correlation between them and levels of miRNA-221 and miRNA-24 (P < 0.05). Logistic regression analysis showed that high levels of serum PCT, low levels of miRNA-221 and miRNA-24 were independent risk factors for lung injury and adverse treatment outcomes in children with severe pneumonia (all P < 0.05). ROC curve analysis showed that the level of this factor had specificity for the risk of adverse disease outcomes, with sensitivities of 0.802, 0.807, 0.814 and 0.845, 0.850, 0.858, respectively, which had high predictive value (AUC>0.70).  Conclusion  The abnormal expression of serum PCT, miRNA-221 and miRNA-24 in children with severe pneumonia is closely related to the occurrence of lung injury and adverse treatment outcomes, and is an independent risk factor and has good predictive value.

     

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