Predictive values of trends in peripheral blood inflammatory indexes for infectious abdominal complications after laparoscopic radical rectal cancer surgery

QIU Quanwei; GE Sitang; ZUO Lugen; LIU Mulin

doi:10.16766/j.cnki.issn.1674-4152.002976

Volume 21 Issue 5

May 2023

Turn off MathJax

Article Contents

Article Navigation > Chinese Journal of General Practice > 2023 > 21(5): 757-760

QIU Quanwei, GE Sitang, ZUO Lugen, LIU Mulin. Predictive values of trends in peripheral blood inflammatory indexes for infectious abdominal complications after laparoscopic radical rectal cancer surgery[J]. Chinese Journal of General Practice, 2023, 21(5): 757-760. doi: 10.16766/j.cnki.issn.1674-4152.002976

Citation:

QIU Quanwei, GE Sitang, ZUO Lugen, LIU Mulin. Predictive values of trends in peripheral blood inflammatory indexes for infectious abdominal complications after laparoscopic radical rectal cancer surgery[J]. Chinese Journal of General Practice, 2023, 21(5): 757-760. doi: 10.16766/j.cnki.issn.1674-4152.002976

Citation:

QIU Quanwei, GE Sitang, ZUO Lugen, LIU Mulin. Predictive values of trends in peripheral blood inflammatory indexes for infectious abdominal complications after laparoscopic radical rectal cancer surgery[J]. Chinese Journal of General Practice, 2023, 21(5): 757-760. doi: 10.16766/j.cnki.issn.1674-4152.002976

PDF( 468 KB)

Predictive values of trends in peripheral blood inflammatory indexes for infectious abdominal complications after laparoscopic radical rectal cancer surgery

doi: 10.16766/j.cnki.issn.1674-4152.002976

QIU Quanwei^{1, 2}
, GE Sitang^{1, 2}
, ZUO Lugen^{1, 2}
, LIU Mulin^{1, 2
,
,}

1.
Department of Gastrointestinal Surgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

2108085MH291

KJ2021ZD0092

BYKC201909

Received Date: 2022-09-21

Abstract

Abstract

Objective To analyze the changes in peripheral blood inflammatory indicators and explore the predictive diagnostic values in predicting the occurrence of Intra-Abdominal Septic Complications (IASCs)in patients after laparoscopic rectal cancer surgery. Methods Patients who underwent laparoscopic radical surgery for rectal cancer in the First Affiliated Hospital of Bengbu Medical College from June 2020 to April 2022 were included as subjects in the study and were divided into IASC group and non-IASC group according to whether IASCs occurred. One hundred and fifty-six patients were included in this study, of which 19 cases (12.18%) were happened. The trend and predictive value of postoperative peripheral TNF-α, CRP and WBC for postoperative IASCs were analyzed in both groups. Results There was no significant difference between two groups in the levels of WBC, CRP and TNF-α in peripheral blood 1-day after surgery (P>0.05). The levels of TNF-α and CRP in peripheral blood 3-day after surgery were higher in IASC group than those in non-IASC group. ROC curve shows that the levels of TNF-α and CRP in peripheral blood 3 days after surgery predicted the occurrence of postoperative IASCs with negative predictive values above 80%, however, the positive predictive values were below 50%. Take ΔTNF-α and ΔCRP into ROC analysis. The results showed that the positive and negative predictive values of ΔTNF-α were superior to those of ΔCRP. Conclusion The changing trend of TNF-α in peripheral blood showed certain predictive and diagnostic values for IASCs after laparoscopic radical rectal cancer surgery.
- Laparoscopic radical resection of colorectal cancer,
- Intra-abdominal septic complications,
- Tumor necrosis factor α,
- C-reactive protein,
- Prognosis

FullText(HTML)

References(18)

References

[1]	SUNG H, FERLAY J, SIEGEL R L, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249. doi: 10.3322/caac.21660
[2]	郑树, 张苏展, 蔡三军, 等. 中国结直肠肿瘤早诊筛查策略专家共识[J]. 中华胃肠外科杂志, 2018, 21(10): 1081-1086. ZHENG S, ZHANG S Z, CAI S J, et al. Expert consensus on Chinese colorectal cancer screening strategies for early detection[J]. Chin J Gastrointest Surg, 2018, 21(10): 1081-1086.
[3]	王琦, 吴舟桥, 侯士阳, 等. 胃结直肠癌术后腹腔感染性并发症的现状研究(PACAGE研究)[J]. 中华消化外科杂志, 2019, 18(3): 229-234. WANG Q, WU Z Q, HOU S Y, et al. Current status of intra-abdominal infectious complications after surgery for gastric and colorectal cancer (PACAGE study)[J]. Chin J Dig Surg, 2019, 18(3): 229-234.
[4]	程一峰. CRP/Alb比值对胰十二指肠切除术后并发症的预测价值[D]. 乌鲁木齐: 新疆医科大学, 2019. CHENG Y F. Predictive value of CRP/Alb ratio for post-pancreaticoduodenectomy complications[D]. Urumqi: Xinjiang Medical University, 2019.
[5]	李子禹, 吴舟桥, 季加孚. 中国胃肠肿瘤外科术后并发症诊断登记规范专家共识(2018版)[J]. 中国实用外科杂志, 2018, 38(6): 589-595. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWK201806001.htm LI Z Y, WU Z Q, JI J F. Expert consensus on the diagnosis of postoperative complications in Chinese gastrointestinal oncology (version 2018)[J]. Chinese Journal of Practical Surgery, 2018, 38(6): 589-595. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWK201806001.htm
[6]	殷洁烽, 张喆, 林聪利. 不同手术方式治疗结直肠癌腹膜转移患者预后效果分析[J]. 中华全科医学, 2018, 16(5): 757-760. doi: 10.16766/j.cnki.issn.1674-4152.000206 YIN J F, ZHANG Z, LIN C L. Outcome analysis of different surgical approaches for patients with colorectal metastases[J]. Chinese Journal of General Practice, 2018, 16(5): 757-760. doi: 10.16766/j.cnki.issn.1674-4152.000206
[7]	曾子威, 康亮. 直肠癌吻合口常见并发症的研究现状[J]. 中华消化外科杂志, 2018, 17(2): 204-207. ZENG Z W, KANG L. Current status of anastomotic complications in rectal cancer[J]. Chinese Journal of Digestive Surgery, 2018, 17(2): 204-207.
[8]	陈伟杰, 林国乐. 直肠癌低位前切除术后吻合口漏诊治现状及展望[J]. 中华胃肠外科杂志, 2021, 24(6): 493-497. CHEN W J, LIN G L. Current status and prospects of anastomotic leakage after low anterior resection for rectal cancer[J]. Chin J Gastrointest Surg, 2021, 24(6): 493-497.
[9]	董明, 周建平, 姚宏伟. 结直肠癌围手术期营养治疗中国专家共识(2019版)[J]. 中国实用外科杂志, 2019, 39(6): 533-537. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWK201906004.htm DONG M, ZHOU J P, YAO H W. Chinese expert consensus on perioperative nutritional therapy for colorectal cancer (2019 edition)[J]. Chinese Journal of Practical Surgery, 2019, 39(6): 533-537. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWK201906004.htm
[10]	匡荣康, 王成龙, 强光辉, 等. 营养状态对结直肠癌病人手术部位感染的影响及相关因素分析[J]. 肠外与肠内营养, 2021, 28(2): 84-87. https://www.cnki.com.cn/Article/CJFDTOTAL-CWCN202102006.htm KUANG R K, WANG C L, QIANG G H, et al. Effect of nutritional status on surgical site infections in patients with colorectal cancer and correlates[J]. Parenteral & Enteral Nutrition, 2021, 28(2): 84-87. https://www.cnki.com.cn/Article/CJFDTOTAL-CWCN202102006.htm
[11]	中华医学会外科学分会结直肠外科学组. 中国直肠癌手术吻合口漏诊断、预防及处理专家共识(2019版)[J]. 中华胃肠外科杂志, 2019, 22(3): 201-206. https://www.cnki.com.cn/Article/CJFDTOTAL-LCWK202001016.htm Colorectal Surgery Group, Surgery Society of Chinese Medical Association, ZHANG Z T. Expert consensus on diagnosis, prevention and management of surgical anastomotic leakage in Chinese rectal cancer (version 2019)[J]. Chin J Gastrointest Surg, 2019, 22(3): 201-206. https://www.cnki.com.cn/Article/CJFDTOTAL-LCWK202001016.htm
[12]	苗儒林, 李子禹, 武爱文. 中国胃肠肿瘤外科联盟数据报告(2014-2016)[J]. 中国实用外科杂志, 2018, 38(1): 90-93. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWK201801028.htm MIAO R L, LI Z Y, WU A W. Chinese Association of Gastrointestinal Oncology Data Report (2014-2016)[J]. Chinese Journal of Practical Surgery, 2018, 38(1): 90-93. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWK201801028.htm
[13]	单剑锋, 俞耀军. 腹腔镜下结直肠癌术后感染并发症的特点及危险因素分析[J]. 中华全科医学, 2017, 15(7): 1153-1155. doi: 10.16766/j.cnki.issn.1674-4152.2017.07.018 SHAN J F, YU Y J. Characteristics and risk factors of infectious complications after laparoscopic surgery for colorectal cancer[J]. Chinese Journal of General Practice, 2017, 15(7): 1153-1155. doi: 10.16766/j.cnki.issn.1674-4152.2017.07.018
[14]	姚宏伟, 许峰铭, 安勇博, 等. 直肠癌术后吻合口漏的早期诊断和预防研究进展[J]. 中华胃肠外科杂志, 2021, 24(6): 480-486. YAO H W, XU F M, AN Y B, et al. Advances in the early diagnosis and prevention of postoperative anastomotic leakage in rectal cancer[J]. Chin J Gastrointest Surg, 2021, 24(6): 480-486.
[15]	XIE T B, ZHAO C Y, DING C, et al. Postoperative interleukin-6 predicts intra-abdominal septic complications at an early stage after elective intestinal operation for Crohn ' s disease patients[J]. Inflamm Bowel Dis, 2018, 24(9): 1992-2000.
[16]	金鑫, 张成武, 才保加, 等. C反应蛋白在胃癌术后吻合口漏的预测价值[J]. 青海医药杂志, 2020, 50(6): 1-5. https://www.cnki.com.cn/Article/CJFDTOTAL-QHYZ202006001.htm JIN X, ZHANG C W, CAI B J, et al. Predictive value of C-reactive protein for anastomotic leakage after gastric surgery[J]. Qinghai Medical Journal, 2020, 50(6): 1-5. https://www.cnki.com.cn/Article/CJFDTOTAL-QHYZ202006001.htm
[17]	李柱, 廖信芳, 吕海钠, 等. 血清CRP、腹腔引流液CRP在预测腹腔镜结直肠癌术后吻合口瘘的临床价值[J]. 广州医科大学学报, 2021, 49(3): 77-82. https://www.cnki.com.cn/Article/CJFDTOTAL-GZXI202103016.htm LI Z, LIAO X F, LYU H N, et al. Clinical utility of serum CRP and intraperitoneal drainage solution CRP in predicting anastomotic leakage after laparoscopic colorectal cancer surgery[J]. Academic Journal of Guangzhou Medical University, 2021, 49(3): 77-82. https://www.cnki.com.cn/Article/CJFDTOTAL-GZXI202103016.htm
[18]	DAS U, ANANDHI A, SURESHKUMAR S, et al. Procalcitonin and C-reactive protein as an early predictor of infection in elective gastrointestinal cancer surgery-a prospective observational study[J]. J Gastrointest Cancer, 2022, 53(3): 605-613.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Figures(2) / Tables(4)

Get Citation

PDF

XML

Article Metrics

Article views (209) PDF downloads(15)

Predictive values of trends in peripheral blood inflammatory indexes for infectious abdominal complications after laparoscopic radical rectal cancer surgery

doi: 10.16766/j.cnki.issn.1674-4152.002976

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Predictive values of trends in peripheral blood inflammatory indexes for infectious abdominal complications after laparoscopic radical rectal cancer surgery

doi: 10.16766/j.cnki.issn.1674-4152.002976

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

Export File

Citation

Format

Content