Volume 21 Issue 5
May  2023
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ZHAO Yuehua, YIN Li, ZHANG Fan, LUO Song, QU Hongdang, XU Li. Correlation of white matter hyperintensity with gait abnormalities and balance disorders[J]. Chinese Journal of General Practice, 2023, 21(5): 773-775. doi: 10.16766/j.cnki.issn.1674-4152.002980
Citation: ZHAO Yuehua, YIN Li, ZHANG Fan, LUO Song, QU Hongdang, XU Li. Correlation of white matter hyperintensity with gait abnormalities and balance disorders[J]. Chinese Journal of General Practice, 2023, 21(5): 773-775. doi: 10.16766/j.cnki.issn.1674-4152.002980
shu

Correlation of white matter hyperintensity with gait abnormalities and balance disorders

doi: 10.16766/j.cnki.issn.1674-4152.002980

  • Department of Neurology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 SK2018A0181

 Byycxz21094

  • Received Date: 2022-12-01
    Abstract
  •   Objective  To assess the correlation of white matter hyperintensity (WMH) in different burdens and regions of the brain with gait abnormalities and balance disorders.  Methods  Eighty-four patients with WMH were included and divided into low burden group (45 cases), moderate burden group (17 cases) and high burden group (22 cases) by the Fazekas scale score. Gait and balance functions were comprehensively evaluated by stride length, stride width, gait speed and Tinetti performance-oriented mobility assessment (POMA) score. Pearson correlation was used to analyze the correlation of WMH in different burdens and regions of the brain with gait abnormalities and balance disorders.  Results  The high burden group had the shortest stride length, largest stride width, slowest gait speed, and lowest POMA score. The difference between groups was statistically significant (P < 0.05). Pearson correlation analysis showed that periventricular WMH had a negative correlation with stride length, gait speed, and POMA score (r=-0.787, -0.480, -0.670, -0.435, -0.600, all P < 0.01), and demonstrated a positive correlation with stride width (r=0.740, P < 0.01). Deep WMH showed a negative correlation with gait speed, total score of POMA and Tinetti balance score (r=-0.402, -0.698, -0.795, all P < 0.05).  Conclusion  WMH correlates with gait abnormalities and balance disorders. The increase of WMH burden is associated with shortened stride length, greater stride width, slower gait speed, and impaired gait and balance functions. Periventricular WMH is highly correlated with gait abnormalities, while deep WMH is strongly correlated with balance disorders.

     

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