Volume 21 Issue 5
May  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(5): 797-800
PAN Hua, DENG Fang. Early prediction of serum 25-hydroxyvitamin D in children with Henoch-Schonlein purpura nephritis[J]. Chinese Journal of General Practice, 2023, 21(5): 797-800. doi: 10.16766/j.cnki.issn.1674-4152.002986
Citation: PAN Hua, DENG Fang. Early prediction of serum 25-hydroxyvitamin D in children with Henoch-Schonlein purpura nephritis[J]. Chinese Journal of General Practice, 2023, 21(5): 797-800. doi: 10.16766/j.cnki.issn.1674-4152.002986
shu

Early prediction of serum 25-hydroxyvitamin D in children with Henoch-Schonlein purpura nephritis

doi: 10.16766/j.cnki.issn.1674-4152.002986
  • 1.

    Department of Kidney Rheumatology, Suzhou Municipal Hospital, Suzhou, Anhui 234000, China

Funds:

 2108085MH262

  • Received Date: 2022-09-22
    Abstract
  •   Objective  To investigate the effect of serum 25 hydroxyvitamin D [25-(OH)D] on Henoch-Schonlein purpura nephritis (HSPN)and to determine the early diagnostic value of serum 25-(OH)D in HSPN.  Methods  A total of 102 cases of Henoch-Schonlein Purpura (HSP) children who were hospitalized in the Department of Pediatrics, Suzhou Municipal Hospital from January 2019 to December 2021 were selected as the case group, including 31 children in HSPN group and 71 children in Non Henoch-Schonlein purpura nephritis (NHSPN)group; 94 healthy children were selected as the healthy control group. The serum 25-(OH)D of children in each group was compared; The risk of serum 25-(OH)D affecting HSPN was analyzed by binary logistic regression analysis; The diagnostic value of serum 25-(OH)D for HSPN was analyzed by subject working characteristic curve.  Results  The level of serum 25-(OH)D in healthy control group was significantly higher than that in HSP group; The level of serum 25-(OH) D in HSPN group were significantly lower than that in the NHSPN group and the HSP group (both P < 0.01). When the serum 25-(OH) D of children in the healthy control group increased, the risk of HSP decreased (OR=0.302, P < 0.001); The serum 25-(OH) D of children in HSP group decreased; The risk of HSPN increased (OR=1.650, P < 0.001). In addition, the area under the ROC curve of serum 25-(OH)D was 0.814 for differentiating HSP from HSPN. Using a cut-off value was 23.34 ng/mL, the sensitivity and specificity were 68.6% and 87.1%, respectively.  Conclusion  Decreased serum 25-(OH)D level may be a risk factor for HSPN, It plays a predictive role in the early onset of HSPN.

     

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