Volume 21 Issue 5
May  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(5): 817-820
ZHANG Ji, ZHANG Chenli, CHEN Ming, REN Jiahui, YAO Bilian, WANG Zhenzhen, CHEN Ying, LU Wei. HP infection in community patients with hypertension treated with aspirin for ASCVD primary prevention[J]. Chinese Journal of General Practice, 2023, 21(5): 817-820. doi: 10.16766/j.cnki.issn.1674-4152.002991
Citation: ZHANG Ji, ZHANG Chenli, CHEN Ming, REN Jiahui, YAO Bilian, WANG Zhenzhen, CHEN Ying, LU Wei. HP infection in community patients with hypertension treated with aspirin for ASCVD primary prevention[J]. Chinese Journal of General Practice, 2023, 21(5): 817-820. doi: 10.16766/j.cnki.issn.1674-4152.002991
shu

HP infection in community patients with hypertension treated with aspirin for ASCVD primary prevention

doi: 10.16766/j.cnki.issn.1674-4152.002991
  • 1.

    Department of General Practice, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Funds:

 200940005

  • Received Date: 2022-03-11
    Abstract
  •   Objective  This study aims to investigate and analyse the current situation of Helicobacter pylori (Hp) infection in community patients with hypertension treated with aspirin for ASCVD primary prevention.  Methods  A total of 100 hypertensive patients who were eligible for ASCVD primary prevention and had been taking low-dose aspirin for a long time in Dapuqiao Community from January 2020 to June 2021 were selected to investigate the previous histories of Helicobacter pylori infection and eradication before taking the medication. Helicobacter pylori testing was performed and grouped according to the results(Hp-positive and Hp-negative groups); atherosclerosis-related indexes were screened, and the test of the two groups were recorded and statistically analysed.  Results  Amongst the selected patients, 13 (13.00%) had been screened for Hp before taking aspirin; 7 cases were found to be infected with Hp through screening, and the Hp infection rate accounted for 53.85% of the screening population. All 7 cases with Hp infection had undergone eradication therapy, and 5 cases were successfully eradicated (the eradication success rate was 71.43%). In addition, 16 cases showed adverse reactions in the course of taking aspirin (the adverse reaction rate was 16.00%). All the selected cases underwent 13C-UBT breath test, and they were divided into the Hp-positive group (n=39) and Hp-negative group (n=61) based on the results. TC, TG and LDL-C in the Hp-positive group were significantly higher than those in the Hp-negative group (all P < 0.01). The comparison of the HOMA-IR index and BMI, which reflecting insulin resistance, between the two groups showed statistically significant differences (both P > 0.05). Carotid intima-media thickness (CIMT) in the Hp-positive group was significantly thicker than that in the Hp-negative group (P < 0.01).  Conclusion  The screening rate and eradication rate of Hp are low in community patients with hypertension treated with aspirin for ASCVD primary prevention. Hp infection may promote atherosclerosis by affecting glucose and lipid metabolism, increasing insulin resistance and increasing carotid intima-media thickness. Furthermore, Hp infection can aggravate the gastrointestinal damage from aspirin. Therefore, Hp should be screened and eradicated before taking medicine.

     

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