Volume 21 Issue 5
May  2023
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(5): 825-828
SUN Qiqi, GAO Kerun. Sleep characteristics and their correlation with cognitive function in patients with mild cognitive impairment[J]. Chinese Journal of General Practice, 2023, 21(5): 825-828. doi: 10.16766/j.cnki.issn.1674-4152.002993
Citation: SUN Qiqi, GAO Kerun. Sleep characteristics and their correlation with cognitive function in patients with mild cognitive impairment[J]. Chinese Journal of General Practice, 2023, 21(5): 825-828. doi: 10.16766/j.cnki.issn.1674-4152.002993
shu

Sleep characteristics and their correlation with cognitive function in patients with mild cognitive impairment

doi: 10.16766/j.cnki.issn.1674-4152.002993

  • Second Department of Psychiatry, Hangzhou Seventh People ' s Hospital, Affiliated Mental Health Center of Zhejiang University Medical College, Hangzhou, Zhejiang 310013, China

Funds:

 2021RC025

  • Received Date: 2022-12-05
    Abstract
  •   Objective  To analyze the sleep characteristics of patients with mild cognitive impairment (MCI), and then analyze the relationship between MCI and cognitive function, so as to provide a basis for delaying cognitive dysfunction in MCI patients.  Methods  A total of 72 MCI patients treated in Hangzhou Seventh People ' s Hospital from February 2019 to February 2022 and 72 healthy physical examiners in the same period were selected as the observation group and control group, respectively. The sleep and cognitive function were compared between the 2 groups, and the correlation between sleep characteristics and cognitive function was also analyzed.  Results  The incidence of sleep disorders in the observation group (44.44%) was significantly higher than that in the control group (13.89%, P < 0.01). Epworth sleep scale (ESS) scores, Pittsburgh sleep quality index (PSQI) total scores, PSQI subjective sleep time, sleep duration, sleep efficiency, sleep disturbance, daytime dysfunction and other scores were significantly higher in the observation group than in the control group (all P < 0.01). The proportion of light sleep (S1+S2) % in the observation group was significantly higher than that in the control group (P < 0.01), while deep sleep period (S3+S4), rapid eye movement (REM) sleep and the proportion of REM sleep in the observation group were significantly lower than that in the control group (all P < 0.01). The total score of Montreal cognitive function assessment scale (Mo-CA) and scores of orientation, memory, visuospatial and executive function, naming, language, attention, abstract generalization and other items in Mo-CA were significantly lower in observation group than in control group (all P < 0.01). ESS score, PSQI total score, PSQI sleep quality, time to fall asleep, sleep duration, sleep efficiency, nighttime sleep disturbance, daytime dysfunction, S3+S4 (%) and the proportion of REM sleep in the PSQI scale were significantly negatively correlated with and Mo-CA scores (r was -0.329 to -0.213, P value was 0.001 to 0.036).  Conclusion  MCI patients have a higher proportion of sleep disorders, and there is a significant correlation between sleep disorders and cognitive function. The worse the sleep quality of patients, the shorter their deep sleep and REM sleep, and the worse their cognitive function.

     

    • FullText(HTML)
  • loading
    • References(15)
  • [1]
    陈泳均. 轻度认知障碍患者睡眠特征及其与认知的相关性分析[D]. 广州: 南方医科大学, 2020.

    CHEN Y J. Sleep characteristics and its correlation with cognition in patients with mild cognitive impairment[D]. Guangzhou: Southern Medical University, 2020.
    [2]
    GEHRMAN P, GOOENRATNE N S, BREWSTER G S, et al. Impact of Alzheimer disease patients' sleep disturbances on their caregivers[J]. Geriatr Nurs, 2018, 39(1): 60-65. doi: 10.1016/j.gerinurse.2017.06.003
    [3]
    陈敏, 宋清扬, 李敏, 等. 老年慢性失眠患者睡眠质量与认知功能的相关性[J]. 国际精神病学杂志, 2021, 48(2): 251-254. https://www.cnki.com.cn/Article/CJFDTOTAL-GWYJ202102017.htm

    CHEN M, SONG Q Y, LI M, et al. Correlation between sleep quality and cognitive function in elderly patients with chronic insomnia[J]. J Int Psychl, 2021, 48(2): 251-254. https://www.cnki.com.cn/Article/CJFDTOTAL-GWYJ202102017.htm
    [4]
    孙海东, 向华奎, 陈杰. 脑卒中后抑郁对睡眠质量和认知功能障碍的影响[J]. 公共卫生与预防医学, 2022, 33(1): 158-160. https://www.cnki.com.cn/Article/CJFDTOTAL-FBYF202201035.htm

    SUN H D, XIANG H K, CHEN J. Effects of post-stroke depression on sleep quality and cognitive dysfunction[J]. Pub Heal Prev Serv, 2022, 33(1): 158-160. https://www.cnki.com.cn/Article/CJFDTOTAL-FBYF202201035.htm
    [5]
    张志洋, 薄奇静, 李峰, 等. 重性抑郁障碍患者认知功能和失眠的相关性研究[J]. 神经疾病与精神卫生, 2022, 22(5): 347-351. https://www.cnki.com.cn/Article/CJFDTOTAL-JBJS202205008.htm

    ZHNAG Z Y, BO J Q, LI F, et al. Correlation between cognitive function and insomnia in patients with major depressive disorder[J]. J Neuro Ment Heal, 2022, 22(5): 347-351. https://www.cnki.com.cn/Article/CJFDTOTAL-JBJS202205008.htm
    [6]
    中国痴呆与认知障碍诊治指南写作组, 中国医师协会神经内科医师分会认知障碍疾病专业委员会. 2018中国痴呆与认知障碍诊治指南(五): 轻度认知障碍的诊断与治疗[J]. 中华医学杂志, 2018, 98(17): 1294-1301. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSJJ202101001.htm

    Chinese Guidelines for Diagnosis and Treatment of dementia and cognitive Disorders, Professional Committee on Cognitive Disorders of Neurology Branch of Chinese Medical Doctor Association. 2018 Chinese Guidelines for the Diagnosis and Treatment of Dementia and Cognitive Disorders (5): Diagnosis and treatment of mild cognitive impairment[J]. Natl Med J China, 2018, 98(17): 1294-1301. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSJJ202101001.htm
    [7]
    ANFORD A M. Mild cognitive impairment[J]. Clin Geriatr Med, 2017, 33(3): 325-337. doi: 10.1016/j.cger.2017.02.005
    [8]
    董丽平, 童萍, 石元洪, 等. 睡眠质量对老年维持性血液透析患者认知功能的影响[J]. 中国老年学杂志, 2020, 40(17): 3774-3776. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ202017060.htm

    DONG L P, DONG P, SHI Y H, et al. Effect of sleep quality on cognitive function in elderly maintenance hemodialysis patients[J]. J Clini Geropsychol, 2020, 40(17): 3774-3776. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ202017060.htm
    [9]
    严春梅, 高曲文. 轻度认知功能损害患者睡眠障碍的临床研究[J]. 实用医学杂志, 2019, 35(12): 1993-1995. https://www.cnki.com.cn/Article/CJFDTOTAL-SYYZ201912030.htm

    YAN C M, GAO Q W. Clinical study of sleep disorders in patients with mild cognitive impairment[J]. J Pract Med, 2019, 35(12): 1993-1995. https://www.cnki.com.cn/Article/CJFDTOTAL-SYYZ201912030.htm
    [10]
    徐从英, 江吉红, 王琰平, 等. 轻度认知障碍患者的睡眠障碍特征分析[J]. 浙江医学, 2022, 44(4): 411-413. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY202305026.htm

    XU C Y, JIANG J H, WANG Y P, et al. Characteristics of sleep disorders in patients with mild cognitive impairment[J]. ZheJiang Med, 2022, 44(4): 411-413. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY202305026.htm
    [11]
    NAISMITH S L, MOWSZOWSKI L. Sleep disturbance in mild cognitive impairment: a systematic review of recent findings[J]. Curr Opin Psychiatry, 2018, 31(2): 153-159.
    [12]
    赵蕴晗, 秦虹云, 诸秉根, 等. 上海市浦东新区轻度认知功能障碍老人的睡眠质量分析[J]. 医药论坛杂志, 2021, 42(3): 67-70. https://www.cnki.com.cn/Article/CJFDTOTAL-HYYX202103017.htm

    ZHAO H Y, QIN H Y, ZHU B G, et al. Sleep quality analysis of the elderly with mild cognitive impairment in Pudong New Area of Shanghai[J]. J Med Forum, 2021, 42(3): 67-70. https://www.cnki.com.cn/Article/CJFDTOTAL-HYYX202103017.htm
    [13]
    英奇素, 毛勇, 朱炜丹, 等. 维持性血液透析患者睡眠质量与轻度认知功能障碍的相关性研究[J]. 浙江中西医结合杂志, 2022, 32(3): 235-238. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJZH202203010.htm

    YING Q S, MAO Y, ZHU W D, et al. Correlation between sleep quality and mild cognitive impairment in maintenance hemodialysis patients[J]. Zhejiang J Int Traditio Chin West Med, 2022, 32(3): 235-238. https://www.cnki.com.cn/Article/CJFDTOTAL-ZJZH202203010.htm
    [14]
    霍燕, 雷小莉, 王艳艳, 等. 慢性阻塞性肺疾病(COPD)患者睡眠与负性心理及认知功能的相关性[J]. 国际精神病学杂志, 2020, 47(3): 583-585, 589. https://www.cnki.com.cn/Article/CJFDTOTAL-GWYJ202003051.htm

    HUO Y, LEI X L, WANG Y Y, et al. Correlation between sleep and negative psychology and cognitive function in patients with chronic obstructive pulmonary disease (COPD)[J]. J Int Psychl, 2020, 47(3): 583-585, 589. https://www.cnki.com.cn/Article/CJFDTOTAL-GWYJ202003051.htm
    [15]
    冯首花, 王艳秋, 庄慧魁. 中枢神经系统γ-氨基丁酸能神经元对睡眠-觉醒调控作用的研究进展[J]. 神经解剖学杂志, 2021, 37(3): 347-351. https://www.cnki.com.cn/Article/CJFDTOTAL-SJJP202103017.htm

    FENG S H, WANG Y Q, ZHUANG H K. Progress in the regulation of sleep-wake by γ-aminobutyric acid neurons in the central nervous system[J]. Chin J Neuroanat, 2021, 37(3): 347-351. https://www.cnki.com.cn/Article/CJFDTOTAL-SJJP202103017.htm
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(5)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (327) PDF downloads(19) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return