Volume 21 Issue 5
May  2023
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SUN Qiqi, GAO Kerun. Sleep characteristics and their correlation with cognitive function in patients with mild cognitive impairment[J]. Chinese Journal of General Practice, 2023, 21(5): 825-828. doi: 10.16766/j.cnki.issn.1674-4152.002993
Citation: SUN Qiqi, GAO Kerun. Sleep characteristics and their correlation with cognitive function in patients with mild cognitive impairment[J]. Chinese Journal of General Practice, 2023, 21(5): 825-828. doi: 10.16766/j.cnki.issn.1674-4152.002993
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Sleep characteristics and their correlation with cognitive function in patients with mild cognitive impairment

doi: 10.16766/j.cnki.issn.1674-4152.002993

  • Second Department of Psychiatry, Hangzhou Seventh People ' s Hospital, Affiliated Mental Health Center of Zhejiang University Medical College, Hangzhou, Zhejiang 310013, China

Funds:

 2021RC025

  • Received Date: 2022-12-05
    Abstract
  •   Objective  To analyze the sleep characteristics of patients with mild cognitive impairment (MCI), and then analyze the relationship between MCI and cognitive function, so as to provide a basis for delaying cognitive dysfunction in MCI patients.  Methods  A total of 72 MCI patients treated in Hangzhou Seventh People ' s Hospital from February 2019 to February 2022 and 72 healthy physical examiners in the same period were selected as the observation group and control group, respectively. The sleep and cognitive function were compared between the 2 groups, and the correlation between sleep characteristics and cognitive function was also analyzed.  Results  The incidence of sleep disorders in the observation group (44.44%) was significantly higher than that in the control group (13.89%, P < 0.01). Epworth sleep scale (ESS) scores, Pittsburgh sleep quality index (PSQI) total scores, PSQI subjective sleep time, sleep duration, sleep efficiency, sleep disturbance, daytime dysfunction and other scores were significantly higher in the observation group than in the control group (all P < 0.01). The proportion of light sleep (S1+S2) % in the observation group was significantly higher than that in the control group (P < 0.01), while deep sleep period (S3+S4), rapid eye movement (REM) sleep and the proportion of REM sleep in the observation group were significantly lower than that in the control group (all P < 0.01). The total score of Montreal cognitive function assessment scale (Mo-CA) and scores of orientation, memory, visuospatial and executive function, naming, language, attention, abstract generalization and other items in Mo-CA were significantly lower in observation group than in control group (all P < 0.01). ESS score, PSQI total score, PSQI sleep quality, time to fall asleep, sleep duration, sleep efficiency, nighttime sleep disturbance, daytime dysfunction, S3+S4 (%) and the proportion of REM sleep in the PSQI scale were significantly negatively correlated with and Mo-CA scores (r was -0.329 to -0.213, P value was 0.001 to 0.036).  Conclusion  MCI patients have a higher proportion of sleep disorders, and there is a significant correlation between sleep disorders and cognitive function. The worse the sleep quality of patients, the shorter their deep sleep and REM sleep, and the worse their cognitive function.

     

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