Volume 21 Issue 6
Jun.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(6): 924-926
SHU Yuping, YU Danqi, RONG Yue, TAO Hongwu, LIU Yuedong. Causal relationship between ulcerative colitis and bronchiectasis based on mendelian randomization[J]. Chinese Journal of General Practice, 2023, 21(6): 924-926. doi: 10.16766/j.cnki.issn.1674-4152.003016
Citation: SHU Yuping, YU Danqi, RONG Yue, TAO Hongwu, LIU Yuedong. Causal relationship between ulcerative colitis and bronchiectasis based on mendelian randomization[J]. Chinese Journal of General Practice, 2023, 21(6): 924-926. doi: 10.16766/j.cnki.issn.1674-4152.003016
shu

Causal relationship between ulcerative colitis and bronchiectasis based on mendelian randomization

doi: 10.16766/j.cnki.issn.1674-4152.003016
  • 1.

    Graduate School of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110847, China

Funds:

 82074449

  • Received Date: 2022-12-30
    Available Online: 2023-08-26
    Abstract
  •   Objective  The association between ulcerative colitis and bronchiectasis can be clinically concurrent, and a two-sample mendelian randomization (MR) approach is used to investigate whether there is an association between the two and to provide recommendations for clinical management.  Methods  Genetic loci closely associated with ulcerative colitis were extracted as instrumental variables and bronchiectasis was the outcome variable in pooled data from the gene-wide association study (GWAS), which was derived from European ethnic groups. The ulcerative colitis data contained a total sample size of 214 620 individuals and 16 380 459 SNPs, and the bronchiectasis data contained a total sample size of 187 824 individuals and 16 380 375 SNPs. MR analysis was performed using the inverse-variance weighted (IVW), MR-Egger regression and the weighted median (WME) respectively, and the causal relationship between ulcerative colitis and bronchiectasis was evaluated by OR and 95% CI, and the Egger-intercept method was used to test for horizontal multiplicity, and the sensitivity analysis was performed using "leave-one-out method".  Results  A total of 123 SNPs were included as instrumental variables, with OR and 95% CI of 1.089 (1.008-1.177), 1.089 (0.909-1.305), and 1.031 (0.918-1.157) for IVW, MR-Egger, and WME results respectively, and P value of less than 0.05 for IVW, indicating that a causal relationship between ulcerative colitis and bronchiectasis was causally related. MR-Egger regression showed an intercept of 3.190×10-5 with a standard error of 0.013 and P=0.998, there was no horizontal pleiotropy for the instrumental variable of exposure factors. Heterogeneity tests showed no heterogeneity and the results of the "leave-one-out" sensitivity analysis were stable.  Conclusion  There is a causal association between ulcerative colitis and bronchiectasis, which increases the risk of developing bronchiectasis.

     

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