Risk factors and long-term prognosis of malignant arrhythmia in elderly patients with dilated cardiomyopathy

LIU Lei; LUO Guiquan; LIU Yijun; LI Xiaoping; REN Hongqiang

doi:10.16766/j.cnki.issn.1674-4152.003024

Volume 21 Issue 6

Jun. 2023

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Article Navigation > Chinese Journal of General Practice > 2023 > 21(6): 958-961

LIU Lei, LUO Guiquan, LIU Yijun, LI Xiaoping, REN Hongqiang. Risk factors and long-term prognosis of malignant arrhythmia in elderly patients with dilated cardiomyopathy[J]. Chinese Journal of General Practice, 2023, 21(6): 958-961. doi: 10.16766/j.cnki.issn.1674-4152.003024

Citation:

LIU Lei, LUO Guiquan, LIU Yijun, LI Xiaoping, REN Hongqiang. Risk factors and long-term prognosis of malignant arrhythmia in elderly patients with dilated cardiomyopathy[J]. Chinese Journal of General Practice, 2023, 21(6): 958-961. doi: 10.16766/j.cnki.issn.1674-4152.003024

Citation:

LIU Lei, LUO Guiquan, LIU Yijun, LI Xiaoping, REN Hongqiang. Risk factors and long-term prognosis of malignant arrhythmia in elderly patients with dilated cardiomyopathy[J]. Chinese Journal of General Practice, 2023, 21(6): 958-961. doi: 10.16766/j.cnki.issn.1674-4152.003024

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Risk factors and long-term prognosis of malignant arrhythmia in elderly patients with dilated cardiomyopathy

doi: 10.16766/j.cnki.issn.1674-4152.003024

1.
Department of Cardiology, Suining Central Hospital, Suining, Sichuan 629000, China

Funds:

2019YFS0345

Received Date: 2023-01-03
Available Online: 2023-08-26

Abstract

Abstract

Objective To investigate the risk factors and long-term prognosis of malignant arrhythmia (MA) in elderly patients with dilated cardiomyopathy. Methods A total of 199 patients with dilated cardiomyopathy over 60 years old who were hospitalized in the Cardiovascular Center of Suining Central Hospital were selected from January 2017 to April 2021. They were divided into MA group (54 cases) and non-MA group (145 cases) according to whether they were complicated with malignant arrhythmia. The risk factors of malignant arrhythmia were analyzed retrospectively. The MA group was followed up and divided into event group and non-event group according to the presence or absence of a composite endpoint event. The survival analysis was performed to clarify the factors affecting prognosis. Results Multifactorial logistic regression analysis of MA group and non-MA group showed that chronic kidney disease, NYHA class Ⅲ-Ⅳ, left ventricular ejection fration (LVEF) < 35%, and frequent premature ventricular beats were independent risk factors for complications of malignant arrhythmias in elderly patients with dilated cardiomyopathy. Kaplan-meier survival analysis of event group and non-event group showed that among elderly patients with dilated cardiomyopathy complicated by malignant arrhythmias, patients with comorbid chronic kidney disease, chronic obstructive pulmonary disease, and frequent premature ventricular beats were at higher risk of cardiac death. The independent variables that were significant for Kaplan-meier survival analysis were included in a multifactorial cox regression model correction, which showed that comorbid chronic obstructive pulmonary disease, frequent premature ventricular beats was an independent risk factor for cardiac death in elderly patients with dilated cardiomyopathy complicated by malignant arrhythmias (HR=7.593, 95% CI: 2.018-28.576, P=0.003; HR=4.090, 95% CI: 1.042-16.057, P=0.043). Conclusion Chronic kidney disease, NYHA class Ⅲ~Ⅳ, LVEF < 35%, and frequent premature ventricular beats are potential risk factors for the development of malignant arrhythmias in elderly patients with dilated cardiomyopathy. For event group, chronic obstructive pulmonary disease, and frequent premature ventricular beats are independent risk factors for prognosis and could better predict cardiac death.
- Dilated cardiomyopathy,
- Arrhythmia,
- Risk factors,
- Prognosis

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References(23)

References

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