Volume 21 Issue 6
Jun.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(6): 966-969
ZHENG Xiang, WANG Shen. Clinical study of self-made Huoxue Shubi Decoction on the treatment of ischemia reperfusion injury after PCI in acute myocardial infarction[J]. Chinese Journal of General Practice, 2023, 21(6): 966-969. doi: 10.16766/j.cnki.issn.1674-4152.003026
Citation: ZHENG Xiang, WANG Shen. Clinical study of self-made Huoxue Shubi Decoction on the treatment of ischemia reperfusion injury after PCI in acute myocardial infarction[J]. Chinese Journal of General Practice, 2023, 21(6): 966-969. doi: 10.16766/j.cnki.issn.1674-4152.003026
shu

Clinical study of self-made Huoxue Shubi Decoction on the treatment of ischemia reperfusion injury after PCI in acute myocardial infarction

doi: 10.16766/j.cnki.issn.1674-4152.003026
  • 1.

    Department of Cardiovascular Medicine, Wenzhou Integrated Hospital of Traditional Chinese and Western Medicine, Wenzhou, Zhejiang 325000, China

Funds:

 2022ZB149

  • Received Date: 2023-02-13
    Available Online: 2023-08-26
    Abstract
  •   Objective  To explore the clinical efficacy, ventricular remodeling, and cardiovascular adverse events of self-made Huoxue Shubi Decoction on patients with ischemia-reperfusion injury (IRI) after percutaneous coronary intervention (PCI) in acute myocardial infarction.  Methods  A total of 96 patients with acute myocardial infarction after PCI surgery in the Department of Cardiovascular Medicine of Wenzhou Integrated Traditional Chinese and Western Medicine Hospital from January 2019 to December 2021 were selected. According to the random number table method, they were randomly divided into a control group and an observation group, with 48 cases each group. The control group was treated with aspirin and ticagrelor, while the observation group was treated with self-made Huoxue Shubi Decoction on the basis of the control group. The clinical efficacy, traditional Chinese medicine syndromes, platelet aggregation, angina pectoris, cardiac function indicators, and cardiovascular adverse events were compared between the two groups.  Results  After 2 months of treatment, the effective rate of the observation group was 95.83% (46/48), while the control group was 79.17% (38/48), with statistically significant (χ2=6.095, P=0.014). After two months of treatment, the scores of chest pain, palpitations, shortness of breath, fatigue, spontaneous sweating, dark purple tongue, and weak pulse in the observation group were lower than those in the control group (all P < 0.05). After 2 months of treatment, the platelet aggregation rate and angina in the two groups were improved and the observation group were better than the control group (all P > 0.05), the left ventricular ejection fraction (LVEF), left ventricular end diastolic volume (LVEDV), left ventricular end systolic volume (LVESV) in the two groups were improved and the observation group were better than the control group (all P < 0.05), and there was no statistically significant difference in the incidence of cardiovascular adverse events between the two groups (P > 0.05).  Conclusion  On the basis of Western medicine treatment, the addition of self-made Huoxue Shubi Decoction has a significant therapeutic effect on IRI after PCI in acute myocardial infarction. It can promote the improvement of symptoms, reduce platelet aggregation, relieve myocardial remodeling, and has high safety.

     

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