Exercise induced cardioprotective effects and related molecular mechanisms

LIU Rui; LU Yan; JIA Yongping; MA Yichao

doi:10.16766/j.cnki.issn.1674-4152.003040

Volume 21 Issue 6

Jun. 2023

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LIU Rui, LU Yan, JIA Yongping, MA Yichao. Exercise induced cardioprotective effects and related molecular mechanisms[J]. Chinese Journal of General Practice, 2023, 21(6): 1021-1025. doi: 10.16766/j.cnki.issn.1674-4152.003040

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LIU Rui, LU Yan, JIA Yongping, MA Yichao. Exercise induced cardioprotective effects and related molecular mechanisms[J]. Chinese Journal of General Practice, 2023, 21(6): 1021-1025. doi: 10.16766/j.cnki.issn.1674-4152.003040

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Exercise induced cardioprotective effects and related molecular mechanisms

doi: 10.16766/j.cnki.issn.1674-4152.003040

LIU Rui¹
, LU Yan^{2
,
,}
, JIA Yongping²
, MA Yichao²

1.
The First Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi 030001, China

Funds:

201903D321180

Received Date: 2022-12-16
Available Online: 2023-08-26

Abstract

Abstract

Cardiovascular disease (CVD) is still the main cause of the global burden of disease at present. Physical inactivity is one of the controllable risk factors for CVD, and in clinical practice, exercise is recommended as an important means of CVD prevention and rehabilitation. Exercise is beneficial in reducing the risk of CVD and improves outcomes as well as health-related quality of life in patients with CVD such as ischemic heart disease and heart failure, and it also ameliorates anthracycline-induced cardiotoxicity. Although the mechanism of exercise-induced cardiovascular protection has not been fully elucidated, the related mechanisms have been extensively studied by animal exercise models. In research, exercise may be used as a preconditioning to render the post exercise heart resistant to pathological stimuli; Exercise intervention can also be performed after the occurrence of the disease, to a certain extent, alleviating cardiac injury and maintaining cardiac function. Mechanistically, exercise-induced cardioprotection is multifaceted and this protective effect is associated with exercise promoting physiological cardiac hypertrophy, inhibiting pathological hypertrophy, promoting cardiomyocyte proliferation, reducing cardiomyocyte apoptosis, improving cardiac fibrosis, and promoting angiogenesis in the heart. The molecular mechanisms involved in exercise-induced cardioprotection involve signaling pathways such as IGF-1/PI3K/Akt, NRG1/ErbB, and Hippo, as well as molecules such as myokines, exercise-induced peptides, sirtuin, exosomes, and miRNAs. In this review, the cardioprotective effects induced by exercise and related molecular mechanisms will be elaborated from the above aspects, in the hope of providing ideas for the prevention and treatment of cardiac diseases and exercise rehabilitation research.
- Exercise,
- Cardiac protection,
- Cardiac hypertrophy,
- Cardiomyocytes,
- Cardiac fibrosis,
- Angiogenesis

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References(40)

References

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Exercise induced cardioprotective effects and related molecular mechanisms

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