Volume 21 Issue 7
Jul.  2023
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(7): 1089-1092
ZHAO Jianhua, ZHANG Jing, CAI Mengmeng, CHAO Linlin, SHI Jingjing, BAO Jieyu. The effect and significance of cerebral infarction location on cognitive function[J]. Chinese Journal of General Practice, 2023, 21(7): 1089-1092. doi: 10.16766/j.cnki.issn.1674-4152.003056
Citation: ZHAO Jianhua, ZHANG Jing, CAI Mengmeng, CHAO Linlin, SHI Jingjing, BAO Jieyu. The effect and significance of cerebral infarction location on cognitive function[J]. Chinese Journal of General Practice, 2023, 21(7): 1089-1092. doi: 10.16766/j.cnki.issn.1674-4152.003056
shu

The effect and significance of cerebral infarction location on cognitive function

doi: 10.16766/j.cnki.issn.1674-4152.003056

  • Department of Neurology, People's Hospital of Zhengzhou University (Henan Provincial People's Hospital), Zhengzhou, Henan 450003, China

Funds:

 SBGJ202102034

  • Received Date: 2022-11-25
    Available Online: 2023-08-28
    Abstract
  •   Objective  To analyze the changes of clinical data and cognitive impairment in patients with cerebral infarction, and to evaluate the effect and significance of infarction location on cognitive function.  Methods  A total of 316 patients with acute cerebral infarction admitted to People's Hospital of Zhengzhou University from January 2020 to January 2021 were enrolled in this prospective observational study. Cognitive function was evaluated at 2 weeks, 6 months, and 12 months after the onset of stroke. According to the evaluation, the patients were divided into a post-stroke cognitive decline group (PSCI group, 44 cases) and a non-decline group (NPSCI group, 272 cases), and the changes of cognitive function were evaluated.  Results  The proportion of infarction sites involving frontal lobe (15.91%, 7/44), basal ganglia (13.64%, 6/44) and thalamus (18.18%, 8/44) in PSCI group were higher than those in NPSCI group [frontal lobe (4.78%, 13/272), basal ganglia (5.51%, 15/272) and thalamus (6.62%, 18/272)], the differences between the two groups were statistically significant (all P < 0.05). Repeated measures analysis of variance showed that the cognitive function scores of the two groups were significantly different (P < 0.001). Pairwise comparison showed that there were statistically significant differences between 2 weeks after onset and 6 and 12 months after onset (P < 0.001). Further generalized estimating equation showed that there were significant differences in the frontal lobe, basal ganglia and thalamus when the infarction was involved (P < 0.05). At the same time, it was found that the difference of cognitive function between 12 months and 2 weeks, 6 months after onset was statistically significant (P < 0.05), that was, time was also an influencing factor of cognitive function.  Conclusion  Long-term cognitive impairment is more likely to occur in patients with infarcts located in frontal lobe, basal ganglia and thalamus.

     

    • FullText(HTML)
  • loading
    • References(17)
  • [1]
    王拥军, 李子孝, 谷鸿秋, 等. 中国卒中报告2020(中文版)(1)[J]. 中国卒中杂志, 2022, 17(5): 433-447. doi: 10.3969/j.issn.1673-5765.2022.05.001

    WANG Y J, LI Z X, GU H Q, et al. China Stroke Statistics 2020(1)[J]. Chinese Journal of Stroke, 2022, 17(5): 433-447. doi: 10.3969/j.issn.1673-5765.2022.05.001
    [2]
    ROST N S, BRODTMANN A, PASE M P, et al. Post-stroke cognitive impairment and dementia[J]. Circ Res, 2022, 130(8): 1252-1271. doi: 10.1161/CIRCRESAHA.122.319951
    [3]
    LC J W, CRAWFORD J D, DESMOND D W, et al. Profile of and risk factors for poststroke cognitive impairment in diverse ethnoregional groups[J]. Neurology, 2019, 93(24): e2257-e2271. DOI: 10.1212/WNL.0000000000008612.
    [4]
    ZHAO L, BIESBROEK J M, SHI L, et al. Strategic infarct location for post-stroke cognitive impairment: a multivariate lesion-symptom mapping study[J]. J Cereb Blood Flow Metab, 2018, 38(8): 1299-1311. doi: 10.1177/0271678X17728162
    [5]
    LEI C Y, DENG Q H, LI H J, et al. Association between silent brain infarcts and cognitive function: a systematic review and meta-analysis[J]. J Stroke Cerebrovasc Dis, 2019, 28(9): 2376-2387. doi: 10.1016/j.jstrokecerebrovasdis.2019.03.036
    [6]
    中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国急性缺血性脑卒中诊治指南2018[J]. 中华神经科杂志, 2018, 51(9): 666-682. doi: 10.3760/cma.j.issn.1006-7876.2018.09.004

    Chinese Society of Neurology, Chinese Stroke Society. Chinese guidelines for diagnosis and treatment of acute ischemic stroke 2018[J]. Chinese Journal of Neurology, 2018, 51(9): 666-682. doi: 10.3760/cma.j.issn.1006-7876.2018.09.004
    [7]
    JIA X F, WANG Z H, HUANG F F, et al. A comparison of the Mini-Mental State Examination (MMSE) with the Montreal Cognitive Assessment (MoCA) for mild cognitive impairment screening in Chinese middle-aged and older population: a cross-sectional study[J]. BMC Psychiatry, 2021, 21(1): 485. doi: 10.1186/s12888-021-03495-6
    [8]
    刘凯, 苏燕, 屈洪党, 等. 血管性认知障碍患者血清胱抑素C水平研究[J]. 中华全科医学, 2023, 21(2): 217-220. doi: 10.16766/j.cnki.issn.1674-4152.002849

    LIU K, SU Y, QU H D, et al. Study of serum cystatin C levels in patients with vascular cognitive impairment[J]. Chinese Journal of General Practice, 2023, 21(2): 217-220. doi: 10.16766/j.cnki.issn.1674-4152.002849
    [9]
    WEAVER N A, KUIJF H J, ABEN H P, et al. Strategic infarct locations for post-stroke cognitive impairment: a pooled analysis of individual patient data from 12 acute ischaemic stroke cohorts[J]. Lancet Neurol, 2021, 20(6): 448-459. doi: 10.1016/S1474-4422(21)00060-0
    [10]
    中国卒中学会血管性认知障碍分会. 卒中后认知障碍管理专家共识2021[J]. 中国卒中杂志, 2021, 16(4): 376-389. doi: 10.3969/j.issn.1673-5765.2021.04.011

    Chinese Society of Vascular Cognitive Impairment. Experts consensus on post-stroke cognitive impairment management 2021[J]. Chinese Journal of Stroke, 2021, 16(4): 376-389. doi: 10.3969/j.issn.1673-5765.2021.04.011
    [11]
    中国医师协会神经内科分会认知障碍专业委员会, 《中国血管性认知障碍诊治指南》编写组. 2019年中国血管性认知障碍诊治指南[J]. 中华医学杂志, 2019, 99(35): 2737-2744. doi: 10.3760/cma.j.issn.0376-2491.2019.35.005

    Committee of Cognitive Disorders, Society of Neurology, Chinese Medical Doctor Association, Writing group of Chinese Guidelines for the diagnosis and treatment of vascular cognitive Impairment. 2019 Chinese guidelines for diagnosis and treatment of vascular cognitive impairment[J]. National Medical Journal of China, 2019, 99(35): 2737-2744. doi: 10.3760/cma.j.issn.0376-2491.2019.35.005
    [12]
    ALSROUJI O K, CHEBL A B. Acute neurointervention for ischemic stroke[J]. Interv Cardiol Clin, 2022, 11(3): 339-347.
    [13]
    KAPSA A, SCHNEIDER J A, YU L, et al. Association of stroke and cerebrovascular pathologies with scam susceptibility in older adults[J]. JAMA Neurol, 2023, 80(1): 49-57. doi: 10.1001/jamaneurol.2022.3711
    [14]
    HELLMUTH J, CLASALETTO K, CUNEO R, et al. Bilateral basal ganglia infarcts presenting as rapid onset cognitive and behavioral disturbance[J]. Neurocase, 2020, 26(2): 115-119. doi: 10.1080/13554794.2020.1728341
    [15]
    章礼勇, 施雪英, 曹莉. 孤立性丘脑梗死后认知障碍的影响因素分析[J]. 中国脑血管病杂志, 2021, 18(6): 378-383, 404. doi: 10.3969/j.issn.1672-5921.2021.06.003

    ZHANG L Y, SHI X Y, CAO L. Analysis of factors influencing cognitive impairment associated with isolated thalamic infarction[J]. Chinese Journal of Cerebrovascular Diseases, 2021, 18(6): 378-383, 404. doi: 10.3969/j.issn.1672-5921.2021.06.003
    [16]
    LLYAS A, TOTH E, CHAITTANYA G, et al. Lctal high-frequency activity in limbic thalamic nuclei varies with electrographic seizure-onset patterns in temporal lobe epilepsy[J]. Clin Neurophysiol, 2022, 137: 183-192.
    [17]
    PARK A J, HARRIS A Z, MARTYNIUK K M, et al. Reset of hippocampal-prefrontal circuitry facilitates learning[J]. Nature, 2021, 591(7851): 615-619. doi: 10.1038/s41586-021-03272-1
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)  / Tables(4)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (193) PDF downloads(18) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return