Volume 21 Issue 7
Jul.  2023
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(7): 1097-1100
HUANG Liangtong, XU Lingyan. Effects of edaravone dexborneol combined with tirofiban on cerebral hemodynamics and oxidative stress in patients with acute cerebral infarction[J]. Chinese Journal of General Practice, 2023, 21(7): 1097-1100. doi: 10.16766/j.cnki.issn.1674-4152.003058
Citation: HUANG Liangtong, XU Lingyan. Effects of edaravone dexborneol combined with tirofiban on cerebral hemodynamics and oxidative stress in patients with acute cerebral infarction[J]. Chinese Journal of General Practice, 2023, 21(7): 1097-1100. doi: 10.16766/j.cnki.issn.1674-4152.003058
shu

Effects of edaravone dexborneol combined with tirofiban on cerebral hemodynamics and oxidative stress in patients with acute cerebral infarction

doi: 10.16766/j.cnki.issn.1674-4152.003058

  • Department of Neurology, the Fifth Affiliated Hospital of Wenzhou Medical University (Lishui Central Hospital), Lishui, Zhejiang 323000, China

Funds:

 2022ZH079

  • Received Date: 2023-04-06
    Available Online: 2023-08-28
    Abstract
  •   Objective  In recent years, the incidence of acute cerebral infarction has been increased year by year. In order to find more effective methods for the treatment of acute cerebral infarction, this study used edaravone dexborneol combined with tirofiban in the treatment of patients with acute cerebral infarction, to investigate its effect on cerebral hemodynamics and oxidative stress.  Methods  A total of 220 patients with acute cerebral infarction who admitted to Lishui Central Hospital from January 2021 to March 2022 were selected as research objects, and they were divided into group A (n=108) and group B (n=112) by therapeutic method. Group A was treated with tirofiban, i.e. conventional treatment, and group B was treated with edaravone dexborneol on the basis of the group A. The clinical efficacy, adverse effects, cerebral hemodynamics, oxidative stress and serum inflammatory factors were compared between the two groups.  Results  After treatment, the national institutes of health stroke scale (NIHSS) of the two groups was significantly lower than that before treatment, and the NIHSS of group B was significantly lower than that of group A [(3.44±0.53) points vs. (3.67±0.77) points, t=2.589, P=0.010]. After treatment, the levels of resistance index, malondialdehyde, norepinephrine, tumor necrosis factor-α, interleukin-6 and hypersensitive C-reactive protein in the two groups were significantly lower than those before treatment, and those in the group B were significantly lower than those in the group A (all P < 0.05); The levels of maximum blood flow velocity, average blood flow velocity, and superoxide dismutase in the two groups were significantly higher than those before treatment, and those in the group B were significantly higher than those in the group A (all P < 0.05). There was no statistically significant difference in the occurrence of gingival bleeding, gastrointestinal reactions, dizziness, headache and intracranial hemorrhage between the two groups (P>0.05).  Conclusion  Edaravone dexborneol in combination with tirofiban showed better efficacy in patients with acute cerebral infarction, which may improve the effects of cerebral hemodynamics, oxidative stress and inflammation, however, had no significant effect on adverse reactions.

     

    • FullText(HTML)
  • loading
    • References(22)
  • [1]
    郝泽林, 吴建跃, 滕振飞, 等. 急性脑梗死患者血清学指标与神经功能缺损和脑梗死体积及颈动脉斑块性质的相关性研究[J]. 中华全科医学, 2020, 18(11): 1803-1806. doi: 10.16766/j.cnki.issn.1674-4152.001623

    HAO Z L, WU J Y, TENG Z F, et al. Correlation of hs-C R P, MMP-9 and Lp-PLA2 with neurological deficit, cerebral infarction volume and carotid plaque properties in patients with acute cerebral infarction[J]. Chinese Journal of General Practice, 2020, 18(11): 1803-1806. doi: 10.16766/j.cnki.issn.1674-4152.001623
    [2]
    王立鹤, 田小溪, 付国强, 等. 阿替普酶溶栓治疗对老年急性脑梗死患者炎症因子、颅内血流动力学及神经功能的影响[J]. 海南医学, 2020, 31(24): 3152-3155. doi: 10.3969/j.issn.1003-6350.2020.24.007

    WANG L H, TIAN X X, FU G Q, et al. Effects of thrombolysis with ateplase on inflammatory factors, intracranial hemodynamics, and neurological function in elderly patients with acute cerebral infarction[J]. Hainan Medical Journal, 2020, 31(24): 3152-3155. doi: 10.3969/j.issn.1003-6350.2020.24.007
    [3]
    ZHAO Y F, ZHANG X J, CHEN X Y, et al. Neuronal injuries in cerebral infarction and ischemic stroke: from mechanisms to treatment (review)[J]. Int J Mol Med, 2022, 49(2): 15.
    [4]
    袁博博, 舒庆, 马冉冉, 等. 吡拉西坦联合阿替普酶静脉溶栓治疗急性脑梗死的疗效及对患者认知功能、血清Hcy、MCP-1水平的影响[J]. 海南医学, 2020, 31(23): 3008-3012. doi: 10.3969/j.issn.1003-6350.2020.23.004

    YUAN B B, SHU Q, MA R R, et al. Efficacy of piracetam combined with alteplase for intravenous thrombolysis in the treatment of acute cerebral infarction and its influence on cognitive function, serum Hcy and MCP-1 level of patients[J]. Hainan Medical Journal, 2020, 31(23): 3008-3012. doi: 10.3969/j.issn.1003-6350.2020.23.004
    [5]
    张颖, 王殷, 宋征宇, 等. 丁苯酞联合血塞通注射液对急性脑梗死早期患者氧化应激及脑血流动力学的影响[J]. 疑难病杂志, 2022, 21(3): 247-251. https://www.cnki.com.cn/Article/CJFDTOTAL-YNBZ202203006.htm

    ZHANG Y, WANG Y, SONG Z Y, et al. Effects of butylphthalide combined with Xuesaitong injection on oxidative stress and cerebral hemodynamics in patients with early acute cerebral infarction[J]. Chinese Journal of Difficult and Complicated Cases, 2022, 21(3): 247-251. https://www.cnki.com.cn/Article/CJFDTOTAL-YNBZ202203006.htm
    [6]
    TANG L S, TANG X Q, YANG Q W. The application of tirofiban in the endovascular treatment of acute ischemic stroke: a meta-analysis[J]. Cerebrovasc Dis, 2021, 50(2): 121-131. doi: 10.1159/000512601
    [7]
    TANAKA M, SUGIMURA N, FUJISAWA A, et al. Stabilizers of edaravone aqueous solution and their action mechanisms. 1. Sodium bisulfite[J]. J Clin Biochem Nutr, 2017, 61(3): 159-163. doi: 10.3164/jcbn.17-61
    [8]
    WANG J Q, CHEN X, YUAN B S, et al. Bioavailability of edaravone sublingual tablet versus intravenous infusion in healthy male volunteers[J]. Clin Ther, 2018, 40(10): 1683-1691. doi: 10.1016/j.clinthera.2018.08.009
    [9]
    中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国急性缺血性脑卒中诊治指南2018[J]. 中华神经科杂志, 2018, 51(9): 666-682. doi: 10.3760/cma.j.issn.1006-7876.2018.09.004

    Chinese Society of Neurology, Chinese Stroke Society. Chinese guidelines for diagnosis and treatment of acute ischemic stroke 2018[J]. Chinese Journal of Neurology, 2018, 51(9): 666-682. doi: 10.3760/cma.j.issn.1006-7876.2018.09.004
    [10]
    ESKIOGLOU E, HUCHMANDZADEH MILLOTTE M, AMIGUET M, et al. National institutes of health stroke scale zero strokes[J]. Stroke, 2018, 49(12): 3057-3059. doi: 10.1161/STROKEAHA.118.022517
    [11]
    陈壁怀. 注射用阿替普酶联合瑞舒伐他汀钙片治疗急性脑梗死的临床效果[J]. 临床合理用药, 2023, 16(5): 49-52. https://www.cnki.com.cn/Article/CJFDTOTAL-PLHY202305015.htm

    CHEN B H. To investigate the clinical effect of alteplase for injection combined with rosuvastatin calcium tablets in the treatment of acute cerebral infarction[J]. Chinese Journal of Clinical Rational Drug Use, 2023, 16(5): 49-52. https://www.cnki.com.cn/Article/CJFDTOTAL-PLHY202305015.htm
    [12]
    KONG Z H, JIANG J, DENG M, et al. Edaravone reduces depression severity in patients with symptomatic intracranial stenosis and is associated with the serum expression of sex hormones[J]. Medicine(Baltimore), 2020, 99(8): e19316. DOI: 10.1097/MD.0000000000019316.
    [13]
    MATSUMOTO S, MUROZONO M, KANAZAWA M, et al. Edaravone and cyclosporine A as neuroprotective agents for acute ischemic stroke[J]. Acute Med Surg, 2018, 5(3): 213-221. doi: 10.1002/ams2.343
    [14]
    LI X Y, ZHANG S N, WANG Z, et al. Platelet function and risk of bleeding in patients with acute coronary syndrome following tirofiban infusion[J]. Front Pharmacol, 2019, 10: 1158. doi: 10.3389/fphar.2019.01158
    [15]
    SUN Z, XU Q, GAO G, et al. Clinical observation in edaravone treatment for acute cerebral infarction[J]. Niger J Clin Pract, 2019, 22(10): 1324-1327. doi: 10.4103/njcp.njcp_367_18
    [16]
    ZENG Y Y, ZHU G P, ZHU M C, et al. Edaravone attenuated particulate matter-induced lung inflammation by inhibiting ROS-NF-κB signaling pathway[J]. Oxid Med Cell Longev, 2022, 2022: 6908884. DOI: 10.1155/2022/6908884.
    [17]
    LI X X, LIU S H, ZHUANG S J, et al. Effects of intravenous thrombolysis with alteplase combined with edaravone on cerebral hemodynamics and T lymphocyte level in patients with acute cerebral infarction[J]. Medicine(Baltimore), 2020, 99(50): e23414. DOI: 10.1097/MD.0000000000023414.
    [18]
    XU L L, GAO Y R, HU M, et al. Edaravone dexborneol protects cerebral ischemia reperfusion injury through activating Nrf2/HO-1 signaling pathway in mice[J]. Fundam Clin Pharmacol, 2022, 36(5): 790-800. doi: 10.1111/fcp.12782
    [19]
    白佳楠. 替罗非班对急性脑梗死患者炎症指标水平、神经功能及肌力的影响研究[J]. 实用中西医结合临床, 2022, 22(3): 70-72. https://www.cnki.com.cn/Article/CJFDTOTAL-SZXL202203021.htm

    BAI J N. Effects of tirofiban on inflammatory index levels, nerve function and muscle strength in patients with acute cerebral infarction[J]. Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine, 2022, 22(3): 70-72. https://www.cnki.com.cn/Article/CJFDTOTAL-SZXL202203021.htm
    [20]
    汪红军. 急诊PCI术中冠脉内应用替罗非班对急性心肌梗死患者心肌灌注水平及氧化应激的影响[J]. 中国临床药学杂志, 2021, 30(2): 86-90. https://www.cnki.com.cn/Article/CJFDTOTAL-LCZZ202102002.htm

    WANG H J. Effect of tirofi ban on myocardial perfusion and oxidative stress in patients with acute myocardial infarction during percutaneous coronary intervention[J]. Chinese Journal of Clinical Pharmacy, 2021, 30(2): 86-90. https://www.cnki.com.cn/Article/CJFDTOTAL-LCZZ202102002.htm
    [21]
    DENG L, JIA H Z, LI M C, et al. Comparison of the effect of ticagrelor combined with tirofiban versus clopidogrel combined with tirofiban on inflammation response and prognosis of patients with unstable angina pectoris in long term follow-up[J]. Kaohsiung J Med Sci, 2021, 37(11): 1010-1015.
    [22]
    LI F, WANG S H, WANG L, et al. The effects of ticagrelor combined with tirofiban on coagulation function, serum myocardial injury markers, and inflammatory factor levels in patients with acute myocardial infarction after percutaneous coronary intervention[J]. Comput Math Methods Med, 2022: 4217270. DOI: 10.1155/2022/4217270.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(5)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (214) PDF downloads(11) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return