Volume 21 Issue 7
Jul.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(7): 1109-1112
HUANG Ting, GONG Huiyuan, TANG Zhen, LI Wei, ZHANG Lei, LI Xiaojun, GAO Xiong. Expression of KLHL7 in non-small cell lung cancer and its clinical significance[J]. Chinese Journal of General Practice, 2023, 21(7): 1109-1112. doi: 10.16766/j.cnki.issn.1674-4152.003061
Citation: HUANG Ting, GONG Huiyuan, TANG Zhen, LI Wei, ZHANG Lei, LI Xiaojun, GAO Xiong. Expression of KLHL7 in non-small cell lung cancer and its clinical significance[J]. Chinese Journal of General Practice, 2023, 21(7): 1109-1112. doi: 10.16766/j.cnki.issn.1674-4152.003061
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Expression of KLHL7 in non-small cell lung cancer and its clinical significance

doi: 10.16766/j.cnki.issn.1674-4152.003061

  • Department of Thoracic Surgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2020A0575

 2020b07030008

  • Received Date: 2022-08-28
    Available Online: 2023-08-28
    Abstract
  •   Objective  To investigate the correlation between the expression of Kelch-like family member 7 (KLHL7) in non-small cell lung cancer (NSCLC) tissue and paracancerous tissue and the prognosis of NSCLC patients.  Methods  The difference of KLHL7 expression in NSCLC tissue and paracancerous tissue was analyzed by using TIMER and UALCAN database respectively. The Kaplan-Meier plotter website was used to analyze the effects of KLHL7 expression levels on the prognosis of patients with NSCLC. A total of 96 patients with NSCLC who received surgical treatment in the First Affiliated Hospital of Bengbu Medical College from January 2014 to December 2016 were selected. Immunohistochemistry was used to detect the expression levels of KLHL7 in NSCLC tissue and paracancerous tissue.  Results  Bioinformatics analysis found that the expression of KLHL7 in NSCLC tissue was significantly increased and the prognosis was poor. Immunohistochemistry staining showed that the positive rate of KLHL7 protein expression in NSCLC tissue was significantly higher than that in paracancerous tissue (57.3% vs. 3.1%, P < 0.001). High KLHL7 expression was significantly correlated with diameter of tumor >3 cm, low tumor cell differentiation, lymph node metastasis and high TNM stage (all P < 0.05). The results of K-M survival analysis showed that tumor diameter, tumor cell differentiation, lymph node metastasis, TNM stage and KLHL7 expression level were all prognostic factors of NSCLC patients (all P < 0.05). Multivariate analysis showed that low tumor cell differentiation, lymph node metastasis, high TNM stage and high KLHL7 expression were independent risk factors affecting postoperative survival time of NSCLC patients (all P < 0.05).  Conclusion  KLHL7 is highly expressed in NSCLC tissue and correlated with tumor progression, which is an independent risk factor affecting prognosis of patients with NSCLC and has certain clinical value for prognosis assessment.

     

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