Predictive role of peripheral blood cell parameters in the cancer development of hydatidiform moles

LI Mingwei; WU Fang; CHENG Jin; ZHOU Ping

doi:10.16766/j.cnki.issn.1674-4152.003074

Volume 21 Issue 7

Jul. 2023

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Article Navigation > Chinese Journal of General Practice > 2023 > 21(7): 1161-1164

LI Mingwei, WU Fang, CHENG Jin, ZHOU Ping. Predictive role of peripheral blood cell parameters in the cancer development of hydatidiform moles[J]. Chinese Journal of General Practice, 2023, 21(7): 1161-1164. doi: 10.16766/j.cnki.issn.1674-4152.003074

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LI Mingwei, WU Fang, CHENG Jin, ZHOU Ping. Predictive role of peripheral blood cell parameters in the cancer development of hydatidiform moles[J]. Chinese Journal of General Practice, 2023, 21(7): 1161-1164. doi: 10.16766/j.cnki.issn.1674-4152.003074

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Predictive role of peripheral blood cell parameters in the cancer development of hydatidiform moles

doi: 10.16766/j.cnki.issn.1674-4152.003074

LI Mingwei^{1
,
,}
, WU Fang²
, CHENG Jin¹
, ZHOU Ping¹

1.
Department of Obstetrics and Gynecology, the First Hospital of Anhui University of Science and Technology, Huainan, Anhui 232000, China

Funds:

AHWJ2021b129

Received Date: 2022-07-08
Available Online: 2023-08-28

Abstract

Abstract

Objective To investigate the clinical value of red blood cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR), platelet count (PLT) and absolute neutrophil count (N) in predicting malignant transformation of hydatidiform mole prior to the initial curettage. Methods A total of 88 hydatidiform moles patients with curettage and follow-up in the Department of Obstetrics and Gynecology of the First Affiliated Hospital of Anhui University of Science and Technology from January 2011 to May 2021 were selected. Patients were divided into malignant group (76 cases) and non-malignant group (12 cases) according to the serum β-HCG results after curettage.The platelet count(PLT), neutrophil(N), neutrophil to lymphocyte ratio(NLR) and red blood cell distribution width (RDW) before the first curettage in the 2 groups were analyzed. The critical value of those markers was calculated by the area under the curve (AUC) statistic derived from the ROC curves. Results (1) Age, gestational weeks, Logβ-HCG, RDW, PDW, N and NLR in patients with malignant group were higher than that in non-malignant group, while absolute lymphocyte values (L) and PLT in the malignant group was significantly lower than that in non-malignant group(P<0.05). (2) Multivariate logistic regression analysis revealed that RDW, NLR and N increase as well as PLT decreased were independent risk factors for hydatidiform mole canceration. (3) ROC curve analysis that among the clinical markers measured before first curettage, for RDW= 14.95, NLR=3.84, N=7.12×10⁹/L and PLT=182.00×10⁹/L, the AUC was estimated as 0.925, 0.946, 0.893 and 0.713, respectively. (4)According to the threshold grouping of RDW, NLR, N and PLT, the malignant transformation rate of high RDW, NLR and N group were higher than patients in the low RDW, NLR and N group, while the malignant transformation rate of low PLT was higher than patients in the high PLT group (P<0.05). Conclusion RDW, NLR, PLT and N with hydatidiform mole patients before the first curettage have certain clinical guiding significance in predicting the malignant transformation of hydatidiform moles.
- Hydatidiform mole,
- Malignancy,
- Gestational trophoblastic disease,
- Neutrophil lymphocyte ratio,
- Red blood cell distribution width,

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References

[1]	MOEIN-VAZIRI N, FALLAHI J, NAMAVAR-JAHROMI B, et al. Clinical and genetic-epignetic aspects of recurrent hydatidiform mole: a review of literature[J]. Taiwan J Obstet Gynecol, 2018, 57(1): 1-6. doi: 10.1016/j.tjog.2017.12.001
[2]	VANICHTANTIKUL A, HODGE K G, SOMPARN P, et al. Proteomic identification of predictive biomarkers for malignant transformation in complete hydatidiform moles[J]. Placenta, 2019, 77(2): 58-64.
[3]	SHAABAN A M, REZVANI M, HAROUN R R, et al. Gestational trophoblastic disease: clinical and imaging features[J]. Radiographics, 2017, 37(2): 681-700. doi: 10.1148/rg.2017160140
[4]	焦澜舟, 王亚萍, 姜继勇, 等. 葡萄胎集中化管理临床意义的探讨[J]. 中华妇产科杂志, 2018, 53(6): 390-395. doi: 10.3760/cma.j.issn.0529-567x.2018.06.006 JIAO L Z, WANG Y P, JIAN J Y, et al. Clinical significance of centralized surveillance of hydatidiform mole[J]. Chinese Journal of Obstetrics and Gynecology, 2018, 53(6): 390-395. doi: 10.3760/cma.j.issn.0529-567x.2018.06.006
[5]	MLEKO M, PITYNSKI K, PLUTA E, et al. Role of systemic inflammatory reaction in female genital organ malignancies-state of the art[J]. Cancer Manag Res, 2021, 13: 5491-5508. doi: 10.2147/CMAR.S312828
[6]	ABU-SHAWER O, ABU-SHAWER M, HIRMAS N, et al. Hematologic markers of distant metastases and poor prognosis in gynecological cancers[J]. BMC Cancer, 2019, 19(1): 141-145. doi: 10.1186/s12885-019-5326-9
[7]	NGAN H Y S, SECKL M J, BERKOWITZ R S, et al. Update on the diagnosis and management of gestational trophoblastic disease[J]. Int J Gynaecol Obstet, 2018, 143(Suppl 2): 79-85.
[8]	AMIN-BEIDOKHTI M, SADEGHI H, PIRJANI R, et al. Differential expression of Hsa-miR-517a/b in placental tissue may contribute to the pathogenesis of preeclampsia[J]. J Turk Ger Gynecol Assoc, 2021, 22(4): 273-278. doi: 10.4274/jtgga.galenos.2021.2021.0062
[9]	王丽娟, 冯凤芝, 林仲秋. 《2020 NCCN妊娠滋养细胞肿瘤临床实践指南(第一版)》解读[J]. 中国实用妇科与产科杂志, 2020, 36(1): 74-79. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGSF202103017.htm WANG L J, FENG F Z, LIN Z Q. Interpretation of 2020NCCN Clinical Practice Guidelines for Gestational Trophoblastic Tumors (First edition)[J]. Chinese Journal of Practical Gynecology and Obstetrics, 2020, 36(1): 74-79. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGSF202103017.htm
[10]	吴龙英, 韦雯雯, 颜士杰. 155例妊娠滋养细胞疾病临床资料分析[J]. 中华全科医学, 2017, 15(3): 457-459. doi: 10.16766/j.cnki.issn.1674-4152.2017.03.029 WU L Y, WEI W W, YAN S J. A clinical analysis of gestational trophoblastic disease: report of 155 cases[J]. Chinese Journal of General Practice, 2017, 15(3): 457-459. doi: 10.16766/j.cnki.issn.1674-4152.2017.03.029
[11]	栾海霞, 陈思, 曾小莉, 等. 全血细胞计数指标监测大动脉炎疾病活动性中的作用[J]. 中华检验医学杂志, 2020, 43(10): 1032-1038. doi: 10.3760/cma.j.cn114452-20200327-00311 LUAN H X, CHEN S, ZENG X L, et al. Role of whole blood cell count indicators in monitoring the activity of Takayasu arteritis[J]. Chinese Journal of Laboratory Medicine, 2020, 43(10): 1032-1038. doi: 10.3760/cma.j.cn114452-20200327-00311
[12]	YAO D S, WANG Z W, CAI H F, et al. Relationship between red cell distribution width and prognosis in patients with breast cancer after operation: a retrospective cohort study[J]. Biosci Rep, 2019, 39(7): BSR20190740. DOI: 10.142/BSR20190740.
[13]	KIM K, YU J, PARK J Y, et al. Low preoperative lymphocyte-to-monocyte ratio is predictive of the 5-year recurrence of bladder tumor after transurethral resection[J]. J Pers Med, 2021, 11(10): 947. doi: 10.3390/jpm11100947
[14]	QIN Y Y, WANG P, HUANG Z B, et al. The value of red cell distribution width in patients with ovarian cancer[J]. Medicine, 2017, 96(17): e6752. DOI: 10.10971/MD.0000000000006752.
[15]	ZHANG L L, XIE Y J, ZHAN L L. The potential value of red blood cell distribution width in patients with invasive hydatidiform mole[J]. J Clin Lab Anal, 2019, 33(4): e22846. DOI: 10.1002/jcla.22846.
[16]	BLOMQVIST L R F, STRANDELL A M, BAGHAEI F, et al. Platelet aggregation in healthy women during normal pregnancy -a longitudinal study[J]. Platelets, 2019, 30(4): 438-444. doi: 10.1080/09537104.2018.1492106
[17]	PENG Y F, WEI Q, SUN J F, et al. First-trimester platelet count as a predictive biomarker for neonatal birth weight among pregnant women at advanced maternal age[J]. Clin Appl Thromb Hemost, 2020, 26(12): 1076029619886907. DOI: 10.1177/1076029619886907.
[18]	张素素, 邵军晖, 张六连. 中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值、β人绒毛膜促性腺激素和宫腔团块最大直径对葡萄胎预后的预测价值[J]. 广西医学, 2019, 41(22): 2875-2878. https://www.cnki.com.cn/Article/CJFDTOTAL-GYYX201922017.htm ZHANG S S, SHAO J J, ZHANG L L. Predictive value of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, human chronic gonadotropin and maximum diameter of intrauterine mass for prognosis of hydatidiform moles[J]. Guangxi Medical Journal, 2019, 41(22): 2875-2878. https://www.cnki.com.cn/Article/CJFDTOTAL-GYYX201922017.htm
[19]	BACANAKGIL B H, KABAN I, UNAL F, et al. Predictive value of hematological inflammatory markers in endometrial neoplasia[J]. Asian Pac J Cancer Prev, 2018, 19(6): 1529-1532.
[20]	潘婉婉, 董孟浩, 余发智, 等. 外周血炎症指标NLR、PLR、LMR预测乳腺癌新辅助化疗疗效的价值[J]. 中华全科医学, 2021, 19(9): 1442-1446. doi: 10.16766/j.cnki.issn.1674-4152.002081 PAN W W, DONG M H, YU F Z, et al. Value of peripheral inflammatory markers NLR, PLR and LMR in predicting the efficacy of neoadjuvant chemotherapy for breast cancer[J]. Chinese Journal of General Practice, 2021, 19(9): 1442-1446. doi: 10.16766/j.cnki.issn.1674-4152.002081
[21]	蒋丽. 对接受葡萄胎清宫术和化疗的葡萄胎患者进行综合护理的效果分析[J]. 当代医药论丛, 2018, 16(12): 253-255. doi: 10.3969/j.issn.2095-7629.2018.12.181 JIANG L. The effect of comprehensive nursing care on patients receiving hydatidiform hydatidialysis and chemotherapy was analyzed[J]. Contemporary Medical Symposium, 2018, 16(12): 253-255. doi: 10.3969/j.issn.2095-7629.2018.12.181
[22]	刘睿, 张涛红, 胡娇娇, 等. 外周血系统性炎症标志物预测完全性葡萄胎恶变的价值研究[J]. 实用妇产科杂志, 2020, 36(1): 31-36. https://www.cnki.com.cn/Article/CJFDTOTAL-SFCZ202001012.htm LIU R, ZHANG T H, HU J J, et al. Predictive value of peripheral systemic inflammatory markers in the malignancy transformation of complete hydatidiform mole[J]. Journal of Practical Obstetrics and Gynecology, 2020, 36(1): 31-36. https://www.cnki.com.cn/Article/CJFDTOTAL-SFCZ202001012.htm

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Predictive role of peripheral blood cell parameters in the cancer development of hydatidiform moles

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