Volume 21 Issue 7
Jul.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(7): 1165-1168
LIU Hui, SANG Xu, WANG Lei, ZHOU Rui, DONG Huaifu. Genotypic characteristics and clinical significance of cytomegalovirus infection in children with thrombocytopenia under 12 months old[J]. Chinese Journal of General Practice, 2023, 21(7): 1165-1168. doi: 10.16766/j.cnki.issn.1674-4152.003075
Citation: LIU Hui, SANG Xu, WANG Lei, ZHOU Rui, DONG Huaifu. Genotypic characteristics and clinical significance of cytomegalovirus infection in children with thrombocytopenia under 12 months old[J]. Chinese Journal of General Practice, 2023, 21(7): 1165-1168. doi: 10.16766/j.cnki.issn.1674-4152.003075
shu

Genotypic characteristics and clinical significance of cytomegalovirus infection in children with thrombocytopenia under 12 months old

doi: 10.16766/j.cnki.issn.1674-4152.003075
  • 1.

    Department of Pediatrics, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 232004, China

Funds:

 BYKY18117

 KJ2021A0742

  • Received Date: 2022-07-16
    Available Online: 2023-08-28
    Abstract
  •   Objective  To collect clinical cases of cytomegalovirus (CMV) related thrombocytopenia in infants and study the relationship between glycoprotein B, H (gB, gH) genotypes and CMV related thrombocytopenia.  Methods  A total of 697 CMV-positive cases treated at the First Affiliated Hospital of Bengbu Medical College from January 2017 to December 2021 were selected, including 29 children with hypoplastic platelets (age < 1 year), all of whom were newly first diagnosed children without persistent thrombocytopenia for >3 months. The genotypes of gB and gH were analyzed by nested polymerase chain reaction (nPCR) and restriction length polymorphism (RFLP).  Results  Among 697 children with CMV infection, 76 cases were congenital infection, 378 cases were perinatal infection and 243 cases were postpartum infection. Twenty-nine CMV-patients with good immune function were analyzed for related thrombocytopenia, including 7 (9.2%) congenital infection, 14 (3.7%) perinatal infection and 8 (3.3%) postpartum infection. Platelet count at diagnosis < 20×109/L was a common manifestation of CMV-related thrombocytopenia in perinatal infection. Among them, the incidence of hepatobiliary symptoms found in the congenital and perinatal infection groups was significantly higher. Immunoglobulin was used in 24 cases, and antiviral drugs were used in 9 cases. The most common CMV genotypes in this study were gB1 (60.7%) and gH2 (57.1%).  Conclusion  Thrombocytopenia is a common clinical manifestation of congenital CMV infection. The gB1 genotype has strong virulence. The gH2 genotype is closely related to thrombocytopenia.

     

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