Volume 21 Issue 7
Jul.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(7): 1169-1171
SUN Yuxiu, TANG Junxiang, WANG Chaohong, WANG Yaqun, WANG Senlin, ZHU Jiansheng. The necessity for a prenatal diagnosis of isolated fetal choroid plexus cyst[J]. Chinese Journal of General Practice, 2023, 21(7): 1169-1171. doi: 10.16766/j.cnki.issn.1674-4152.003076
Citation: SUN Yuxiu, TANG Junxiang, WANG Chaohong, WANG Yaqun, WANG Senlin, ZHU Jiansheng. The necessity for a prenatal diagnosis of isolated fetal choroid plexus cyst[J]. Chinese Journal of General Practice, 2023, 21(7): 1169-1171. doi: 10.16766/j.cnki.issn.1674-4152.003076
shu

The necessity for a prenatal diagnosis of isolated fetal choroid plexus cyst

doi: 10.16766/j.cnki.issn.1674-4152.003076

  • Genetic Center, Anhui Province Maternal and Child Health Hospital, Hefei, Anhui 230001, China

Funds:

 202004j07020004

  • Received Date: 2022-11-05
    Available Online: 2023-08-28
    Abstract
  •   Objective  Karyotype analysis and chromosomal microarray analysis were used to explore the necessity of prenatal diagnosis of choroid plexus cyst (CPC), to provide a basis for prenatal consultation.  Methods  A total of 276 pregnant women who were diagnosed as fetal choroid plexus cysts by ultrasound and voluntarily underwent amniotic fluid puncture after prenatal consultation in Anhui Maternal and Child Health Hospital were selected from January 2017 to January 2022. All pregnant women were divided into 5 groups based on whether they incorporate high-risk factors. G-band chromosome karyotype analysis and chromosome microarray analysis (CMA) were performed to analyze the incidence of chromosomal abnormalities in choroid plexus cysts in each group.  Results  Total 18 cases of chromosomal abnormalities were detected in 276 cases. There were 105 cases of isolated choroid plexus cyst, including 5 cases of chromosomal abnormalities; 45 elderly patients with choroid plexus cyst (the age of pregnant women was older than 35 years old), including 4 cases of chromosomal abnormalities; 84 cases of high risk of choroid plexus cyst combined with serological screening, including 6 cases of chromosomal abnormalities; 35 cases of choroid plexus cyst with other ultrasonic soft indexes, including 2 cases of chromosomal abnormalities; 7 cases of complex choroid plexus cysts (combined with advanced age, high risk of serological screening and other ultrasound soft indicators, more than two of the three), including 1 case of chromosomal abnormalities. There was no significant difference between the 5 groups. In addition, there were 60 cases of unilateral choroid plexus cysts, including 2 cases of chromosomal abnormalities, and 45 bilateral cases, including 3 cases of chromosomal abnormalities, an there were no statistical difference between the two groups.  Conclusion  Isolated choroid plexus cyst also needs prenatal diagnosis as choroid plexus cyst with other high-risk factors.

     

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