Volume 21 Issue 8
Aug.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(8): 1308-1311
LUO Hui, YE Guoliu, JIN Maosheng. Analysis of the pathogenic microorganisms and drug treatment of acute pelvic inflammatory disease[J]. Chinese Journal of General Practice, 2023, 21(8): 1308-1311. doi: 10.16766/j.cnki.issn.1674-4152.003109
Citation: LUO Hui, YE Guoliu, JIN Maosheng. Analysis of the pathogenic microorganisms and drug treatment of acute pelvic inflammatory disease[J]. Chinese Journal of General Practice, 2023, 21(8): 1308-1311. doi: 10.16766/j.cnki.issn.1674-4152.003109
shu

Analysis of the pathogenic microorganisms and drug treatment of acute pelvic inflammatory disease

doi: 10.16766/j.cnki.issn.1674-4152.003109

  • Department of Gynecology and Obstetrics, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 KJ2019A0343

 BYKY2019120ZD

  • Received Date: 2022-07-27
    Available Online: 2023-09-13
    Abstract
  •   Objective  To investigate the types, characteristics, resistance and treatments of pathogenic microorganisms in patients with acute pelvic inflammatory disease, which will help patients to find an appropriate treatment plan.  Methods  From January 2019 to January 2021, a retrospective analysis was conducted on the data of 100 patients who visited the gynaecology department of the First Affiliated Hospital of Bengbu Medical College. Based on the results of the retrospective analysis, the drug resistance of pathogenic microorganisms was investigated.  Results  Many causes of the disease, including irregular vaginal bleeding, abortion. The main symptoms of the disease are fever, abdominal pain and increased vaginal discharge. Escherichia coli and Staphylococcus epidermidis were the most common pathogenic microorganisms detected in 100 patients. All patients were treated with intravenous antibiotics, and the temperature and white blood cell count returned to normal in a shorter time in patients treated with third-generation cephalosporins (P < 0.05). The drug sensitivity test showed that penicillin had been tested and the drug resistance rate was 56.3%. Cephalosporin had been tested and the drug resistance rate was 23.8%. There was a significant difference (P < 0.05) in the number of white blood cells in the blood when the patients were treated with susceptibility antibiotic compared to the resistant antibiotic. Moreover, the results of serial passage experiment to treat microorganisms showed that there was a clear difference in the time it took bacteria to develop resistance to different antibiotics. At the end of the passages, the concentration that inhibited the growth of 90% of the bacteria had increased 64-fold.  Conclusion  There are many pathogenic microorganisms in acute pelvic inflammatory disease, the predominant pathogens of acute pelvic inflammatory disease are Escherichia coli and Staphylococcus epidermidis. Moreover, third-generation cephalosporins are superior to second-generation cephalosporins in treating patients with antibiotics. In addition, there is less resistance to quinolones and aminoglycosides, which may be the first choice of clinical treatment. Furthermore, Pathogenic microorganism can easily develop resistance, highlighting the importance of the accuracy of empirical medication. Of course, the selection of specific antibiotics should be based on comprehensive identification of bacterial culture, drug sensitivity tests and clinician experiences.

     

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