Correlation of mild depression in patients with cerebral small vessel disease and iron content in red nucleus

LI Hua; YANG Hua; FAN Xueyi; LIANG Li; QIAN Hairong

doi:10.16766/j.cnki.issn.1674-4152.003110

Volume 21 Issue 8

Aug. 2023

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LI Hua, YANG Hua, FAN Xueyi, LIANG Li, QIAN Hairong. Correlation of mild depression in patients with cerebral small vessel disease and iron content in red nucleus[J]. Chinese Journal of General Practice, 2023, 21(8): 1312-1314. doi: 10.16766/j.cnki.issn.1674-4152.003110

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LI Hua, YANG Hua, FAN Xueyi, LIANG Li, QIAN Hairong. Correlation of mild depression in patients with cerebral small vessel disease and iron content in red nucleus[J]. Chinese Journal of General Practice, 2023, 21(8): 1312-1314. doi: 10.16766/j.cnki.issn.1674-4152.003110

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Correlation of mild depression in patients with cerebral small vessel disease and iron content in red nucleus

doi: 10.16766/j.cnki.issn.1674-4152.003110

LI Hua¹
, YANG Hua²
, FAN Xueyi³
, LIANG Li²
, QIAN Hairong^{1, 2, 3
,
,}

1.
Department of Neurology, the Third Medical Center of PLA General Hospital, Beijing 100089, China

Funds:

首发2020-2-5115

Received Date: 2023-02-15
Available Online: 2023-09-13

Abstract

Abstract

Objective To investigate the relationship between mild depression and iron content in the red nucleus in cerebral small vessel disease (CSVD) patients and evaluated the predictive value of red nucleus in mild depression CSVD patients (control group). Methods Forty-one patients with mildly depressed CSVD (experimental group) and 40 patients with non-depressed CSVD attending the Department of Neurology of the General Hospital of the People ' s Liberation Army (PLA) from May 1, 2021 to April 30, 2022 were collected. The depression levels were assessed by the geriatric depression scale (GDS). All subjects underwent magnetic resonance susceptibility weighted imaging scans, the iron content in red nucleus of CSVD patients were semi-quantitatively analyzed using susceptibility weighted imaging (SWI) signal intensity in the region of interest (ROI). The signal intensity in the ROI of the red nucleus was measured by 2 physicians. The iron contents in the red nucleus of the two groups were analyzed and the correlation between mild depression and iron content in the red nucleus of CSVD patients was explored. Results The signal intensity in the left red nucleus ROI (189.36±27.55 vs. 213.32±34.33) and the average signal intensity in the red nucleus ROI (193.06±26.33 vs. 211.64±33.53) of the mild depression CSVD group were significantly lower than those of the control group (P < 0.05), while the signal intensity of the right red nucleus ROI in the mild depression CSVD group were not different from those of the control group. Correlation analysis showed that the mean signal intensity in the red nucleus ROI was negatively correlated with depression, the left signal strength in the red nucleus ROI was negatively correlated with depression. Conclusion Mild depression in CSVD is significantly associated with iron content in the red nucleus, and the content of iron in the red nucleus has a certain value in predicting mild depression of CSVD.
- Depression,
- Small cerebral vascular disease,
- Susceptibility weighted imaging,
- Red nucleus

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Correlation of mild depression in patients with cerebral small vessel disease and iron content in red nucleus

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