Volume 21 Issue 8
Aug.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(8): 1379-1382
SUN Jingyan, WU Chen, YU Guoqiang, YU Xiaohong, YANG Tiansong. Application Value of-Vascular Dementia related Biomarkers and Research Progress of Acupuncture intervention Plan[J]. Chinese Journal of General Practice, 2023, 21(8): 1379-1382. doi: 10.16766/j.cnki.issn.1674-4152.003127
Citation: SUN Jingyan, WU Chen, YU Guoqiang, YU Xiaohong, YANG Tiansong. Application Value of-Vascular Dementia related Biomarkers and Research Progress of Acupuncture intervention Plan[J]. Chinese Journal of General Practice, 2023, 21(8): 1379-1382. doi: 10.16766/j.cnki.issn.1674-4152.003127
shu

Application Value of-Vascular Dementia related Biomarkers and Research Progress of Acupuncture intervention Plan

doi: 10.16766/j.cnki.issn.1674-4152.003127
  • 1.

    Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China

Funds:

 82074539

 20211212010322

 2020KY-12

 GY2022-19

  • Received Date: 2023-02-06
    Available Online: 2023-09-13
    Abstract
  • Vascular dementia (VD) is a progressive cognitive disability syndrome caused by reduced blood supply to the brain caused by cerebrovascular diseases, and its incidence is second only to Alzheimer's disease (AD). The prevalence rate of VD in China ranges from 1.1%-3.0%, and the number of patients with dementia is as high as 20% of the global population. Patients suffer from memory loss, cognitive dysfunction and other symptoms, so that they lose the ability to take care of themselves, which places a great burden to their families and society. With the aging of population, the increasing number of patients and the increasing cost of treatment, how to deal with VD caused by the above factors has become a public health problem facing the world. At present, the pathogenesis is not clear, and there is no effective treatment, as the only type of dementia that can be prevented, how to prevent VD has become the focus and difficulty of clinical research. Biomarkers reflect certain characteristics in the course of disease treatment, and related biomarkers play an important role in the early diagnosis, pathogenesis, guidance of treatment strategies, prognosis assessment and other aspects of VD. Long-term use of Western medicine will produce a variety of adverse effects such as drug resistance and dependence. Therefore, many studies have combined acupuncture with Chinese herbal formulas and western drugs on the basis of traditional Chinese medicine theory, and selected acupuncture point formulas according to the patient's individual constitution and the underlying condition, all of which have achieved good clinical effects. In this paper, the literature related to VD acupuncture research in the past 5 years was retrieved from the China Journal Full-text Database (CNKI). Many biomarkers related to vascular dementia were found and classified according to their molecular categories. This paper summarized and commented on the application value of VD in the diagnosis and treatment of vascular dementia, the intervention effect of targeted acupuncture and special acupuncture methods, which provided certain ideas for the treatment and research of VD.

     

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    • References(41)
  • [1]
    汪国余, 施一鸣, 王增献, 等. 头颅核磁共振用于诊断缺血性脑卒中后血管性痴呆的临床观察[J]. 中华全科医学, 2021, 19(6): 998-1000, 1025. doi: 10.16766/j.cnki.issn.1674-4152.001970

    WANG G Y, SHI Y M, WANG Z X, et al. Observe on the clinical effect of MRI in vascular dementia after ischemic stroke[J]. Chinese Journal of General Practice, 2021, 19(6): 998-1000, 1025. doi: 10.16766/j.cnki.issn.1674-4152.001970
    [2]
    钟文清, 陈晓瑜, 刘丹丹. 血管性痴呆患者血清神经调节蛋白1、神经元正五聚蛋白2的表达及临床意义[J]. 临床神经病学杂志, 2023, 36(1): 28-33. https://www.cnki.com.cn/Article/CJFDTOTAL-LCSJ202301023.htm

    ZHONG W Q, CHEN X Y, LIU D D. Expression and clinical significance of serum neuregulin 1 and neuronal pentraxin 2 in patients with vascular dementia[J]. Journal of Clinical Neurology, 2023, 36(1): 28-33. https://www.cnki.com.cn/Article/CJFDTOTAL-LCSJ202301023.htm
    [3]
    王飞, 王民集. 五神针治疗轻中度痰浊阻窍型血管性痴呆的临床观察[J]. 辽宁中医杂志, 2017, 44(12): 2617-2619. doi: 10.13192/j.issn.1000-1719.2017.12.051

    WANG F, WANG M J. Acupuncture at Baihui and Sishencong in Treatment of Vascular Dementia of Phlegm Obstructing Intelligence Type[J]. Liaoning Journal of Traditional Chinese Medicine, 2017, 44(12): 2617-2619. doi: 10.13192/j.issn.1000-1719.2017.12.051
    [4]
    KALARIA R N. The pathology and pathophysiology of vascular dementia[J]. Neuropharmacology, 2018, 134(Pt B): 226-239.
    [5]
    杨静雯, 林丽婷, 李天然, 等. 针刺对血管性痴呆大鼠前额叶皮层炎症水平的影响[J]. 中国中医药信息杂志, 2018, 25(6): 48-52. doi: 10.3969/j.issn.1005-5304.2018.06.012

    YANG J W, LIN L T, LI T R, et al. Effects of Acupuncture on Inflammation in Prefrontal Cortex of Vascular Dementia Rats[J]. Chinese Journal of Information on Traditional Chinese Medicine, 2018, 25(6): 48-52. doi: 10.3969/j.issn.1005-5304.2018.06.012
    [6]
    徐亚丽, 姚莉, 何小蓉, 等. 老年血管性痴呆患者血清C反应蛋白及白介素6检测分析[J]. 中国实用神经疾病杂志, 2018, 21(12): 1334-1337. https://www.cnki.com.cn/Article/CJFDTOTAL-HNSJ201812011.htm

    XU Y L, YAO L, HE X R, et al. Observation of serum CRP and IL-6 level in old patients with vascular dementia[J]. : Chinese Journal of Practical Nervous Diseases, 2018, 21(12): 1334-1337. https://www.cnki.com.cn/Article/CJFDTOTAL-HNSJ201812011.htm
    [7]
    贺海霞, 易健, 李丹丹, 等. 血管性痴呆患者中医证型与炎症因子相关性分析[J]. 湖南中医药大学学报, 2018, 38(12): 1403-1406. doi: 10.3969/j.issn.1674-070X.2018.12.011

    HE H X, YI J, LI D D, et al. Correlation Between TCM Syndrome Types and Inflammatory Factors in Patients with Vascular Dementia[J]. Journal of Hunan University of Chinese Medicine, 2018, 38(12): 1403-1406. doi: 10.3969/j.issn.1674-070X.2018.12.011
    [8]
    刘硕. 瑞舒伐他汀对老年血管性痴呆患者氧化应激及血清IL-6、IL-1β、TNF-α水平的影响[J]. 中国实用医药, 2022, 17(4): 165-167. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSSA202204063.htm

    LIU S. Effects of Rosuvastatin on oxidative stress and serum levels of IL-6, IL-1β and TNF-α in elderly patients with vascular dementia[J]. China Practical Medicine, 2022, 17(4): 165-167. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSSA202204063.htm
    [9]
    师千与, 程全成, 陈春花. 缺血性脑卒中与血管性痴呆在发病机制上的联系[J]. 解剖学报, 2021, 52(5): 834-838. doi: 10.16098/j.issn.0529-1356.2021.05.025

    SHI Q Y, CHENG Q C, CHEN C H. Relationship of pathogenesis between ischemic stroke and vascular dementia[J]. Acta Anatomica Sinica, 2021, 52(5): 834-838. doi: 10.16098/j.issn.0529-1356.2021.05.025
    [10]
    郭明冬, 刘美霞, 韦云, 等. 戟天健脑方对老龄血管性痴呆模型大鼠海马IL-1β、TNF-α的影响[J]. 世界中西医结合杂志, 2021, 16(2): 294-297. doi: 10.13935/j.cnki.sjzx.210221

    GUO M D, LIU M X, WEI Y, et al. The Effects of Jitian Jiannao Decoction on IL-1β and TNF-α in Hippocampus of Senile Vascular Dementia Model Rats[J]. World Journal of Integrated Traditional and Western Medicine, 2021, 16(2): 294-297. doi: 10.13935/j.cnki.sjzx.210221
    [11]
    赵蒲宇. 血清AGEs和IL-1β及TNF-α水平与急性脑梗死后出血性转化的相关性[J]. 医药论坛杂志, 2022, 43(23): 101-104. https://www.cnki.com.cn/Article/CJFDTOTAL-HYYX202223025.htm

    ZHAO P Y. Correlation of serum levels of AGEs, IL-1β and TNF-α with hemorrhagic transformation after acute cerebral infarction[J]. Journal of Medical Forum, 2022, 43(23): 101-104. https://www.cnki.com.cn/Article/CJFDTOTAL-HYYX202223025.htm
    [12]
    贾东佩, 朱风俊, 任应国. 脂蛋白相关磷酸酶A2和炎性蛋白在诊断脑梗死后血管性痴呆及判断预后中的应用[J]. 分子诊断与治疗杂志, 2020, 12(1): 55-58, 73. https://www.cnki.com.cn/Article/CJFDTOTAL-YXYQ202001013.htm

    JIA D P, ZHU F J, REN Y G. Application of lipoprotein-associated phosphatase A2 and inflammatory proteins in diagnosing vascular dementia and predicting prognosis after cerebral infarction[J]. Journal of Molecular Diagnostics and Therapy, 2020, 12(1): 55-58, 73. https://www.cnki.com.cn/Article/CJFDTOTAL-YXYQ202001013.htm
    [13]
    熊燕华, 张大庆. 《脂蛋白相关磷脂酶A2临床应用中国专家建议》解读[J]. 中国医药导刊, 2018, 20(3): 138-145. https://www.cnki.com.cn/Article/CJFDTOTAL-DKYY201803003.htm

    XIONG Y H, ZHAHG D Q. Interpretation of the Clinical Application of lipoprotein-associated phospholipase A2 by Chinese experts[J]. Chinese Journal of Medicinal Guide, 2018, 20(3): 138-145. https://www.cnki.com.cn/Article/CJFDTOTAL-DKYY201803003.htm
    [14]
    罗伏钢, 陈梅芳, 章隆, 等. ApoE基因多态性与脑梗死后血管性痴呆的关联性研究[J]. 中华全科医学, 2018, 16(6): 874-877. doi: 10.16766/j.cnki.issn.1674-4152.000239

    LUO F G, CHEN M F, ZHANG L, et al. Association study between ApoE genetic polymorphism and vascular dementia after cerebral infarction[J]. Chinese Journal of General Practice, 2018, 16(6): 874-877. doi: 10.16766/j.cnki.issn.1674-4152.000239
    [15]
    李易蒸, 张庆欣, 杨晓莉, 等. 急性缺血性脑卒中侧支循环与血管内皮细胞生长因子和碱性成纤维细胞生长因子的相关性[J]. 中华老年心脑血管病杂志, 2022, 24(1): 67-70. https://www.cnki.com.cn/Article/CJFDTOTAL-LNXG202201018.htm

    LI Y Z, ZHANG Q X, YANG X L, et al. Relationship of collateral circulation with VEGF and bFGF in acute ICS patients[J]. Chinese Journal of Geriatric Heart Brain and Vessel Diseases, 2022, 24(1): 67-70. https://www.cnki.com.cn/Article/CJFDTOTAL-LNXG202201018.htm
    [16]
    向伟, 魏新宇, 余彪. 急性脑梗死患者血清miR-21和HIF-1α、VEGF-A的表达关系及临床意义[J]. 医学研究杂志, 2019, 48(2): 105-110. https://www.cnki.com.cn/Article/CJFDTOTAL-YXYZ201902027.htm

    XIANG W, WEI X Y, YU B. Expression of Serum miR-21 and HIF-1α and VEGFA in Patients with Acute Cerebral Infarction and its Clinical Significance[J]. Journal of Medical Research, 2019, 48(2): 105-110. https://www.cnki.com.cn/Article/CJFDTOTAL-YXYZ201902027.htm
    [17]
    贾晶晶, 李伟. 开窍醒神法对急性缺血性脑卒中病人神经功能、S100B蛋白及VEGF表达的影响[J]. 中西医结合心脑血管病杂志, 2020, 18(7): 1060-1063. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYY202007006.htm

    JIA J J, LI W. Effects of resuscitate on neurologic function, S100B protein and VEGF expression in patients with acute ischemic stroke[J]. Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease, 2020, 18(7): 1060-1063 https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYY202007006.htm
    [18]
    高音来, 田浩梅, 陈楚淘, 等. "调心通督"针刺法对血管性痴呆大鼠学习记忆能力及海马组织VEGF、Ang-1蛋白表达的影响[J]. 中国针灸, 2020, 40(10): 1108-1112. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZE202010023.htm

    GAO Y L, TIAN H M, CHEN C T, et al. Effect of acupuncture technique of Tiaoxin Tongdu on learning-memory ability and expressions of hippocampal VEGF and Ang-1 in rats with vascular dementia[J]. Chinese Acupuncture & Moxibustion, 2020, 40(10): 1108-1112. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGZE202010023.htm
    [19]
    张涓, 吕姣姣, 李豪, 等. 整合素α6β1与Ang-1/Tie-2对脑缺血血管神经再生的研究[J]. 现代中医药, 2018, 38(4): 122-129. https://www.cnki.com.cn/Article/CJFDTOTAL-XDZY201804040.htm

    ZHANG J, LYU J J, LI H, et al. Effects of integrin α6β1 and Ang-1/Tie-2 on neural regeneration in cerebral ischemia[J]. Modern Traditional Chinese Medicine, 2018, 38(4): 122-129. https://www.cnki.com.cn/Article/CJFDTOTAL-XDZY201804040.htm
    [20]
    丁佳统, 郭家豪, 洪芬芳, 等. 一氧化氮在血管性痴呆发病及防治中的作用[J]. 南昌大学学报(医学版), 2022, 62(1): 83-88, 98. https://www.cnki.com.cn/Article/CJFDTOTAL-JXYB202201017.htm

    DING J T, GUO J H, HONG F F, et al. Role of Nitric Oxide in Pathogenesis, Prevention and Treatment of Vascular Dementia[J]. Journal of Nanchang University: Medical Sciences, 2022, 62(1): 83-88, 98. https://www.cnki.com.cn/Article/CJFDTOTAL-JXYB202201017.htm
    [21]
    ALLY A, POWELL I, ALLY M M, et al. Role of neuronal nitric oxide synthase on cardiovascular functions in physiological and pathophysiological states[J]. Nitric Oxide, 2020, 102: 52-73.
    [22]
    WANG Y H, DUAN K D, ZHANG A H, et al. Clinical and imaging analysis of cerebral infarction caused by spontaneous cerebral artery dissection based on augmented reality technology[J]. J Healthc Eng, 2021, 2021: 6671121. DOI: 10.1155/2021/6671121.
    [23]
    王翠玉, 张燕锋. 血清Lp-PLA2, BDNF及Ang1-7表达水平与血管性痴呆患者病情严重程度的相关性[J]. 卒中与神经疾病, 2020, 27(4): 474-478. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYS202004013.htm

    WANG C Y, ZHANG Y F. The correlation between Lp-PLA2, BDNF, Ang1-7 levels and disease severity in patients with vascular dementia[J]. Stroke and Nervous Diseases, 2020, 27(4): 474-478. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYS202004013.htm
    [24]
    范祥柱. 盐酸多奈哌齐治疗血管性痴呆的效果及对患者血清胰岛素样生长因子-1水平的影响[J]. 当代临床医刊, 2022, 35(2): 21-22. https://www.cnki.com.cn/Article/CJFDTOTAL-GQYK202202011.htm

    FAN X Z. Effect of Donepezil hydrochloride on vascular dementia and its effect on serum insulin-like growth factor-1 level in patients[J]Journal of Contemporary Clinical Medicine, 2022, 35(2): 21-22. https://www.cnki.com.cn/Article/CJFDTOTAL-GQYK202202011.htm
    [25]
    林雨芳. 电针后海穴对血管性痴呆大鼠海马区IGF-1蛋白表达的影响[J]. 中外医疗, 2018, 37(9): 30-33. https://www.cnki.com.cn/Article/CJFDTOTAL-HZZZ201809010.htm

    LIN Y F. Effect of Sea Cave after the Electroacupuncture on the Expression of IGF-1 Protein in Hippocampal Region of the Vascular Dementia Rats[J]. China & Foreign Medical Treatment, 2018, 37(9): 30-33. https://www.cnki.com.cn/Article/CJFDTOTAL-HZZZ201809010.htm
    [26]
    封晓荣, 张岁龙, 黄春春. 针刺联合丁基苯酞胶囊对血管性痴呆患者认知功能及MRI成像的影响[J]. 心血管康复医学杂志, 2019, 28(2): 233-237. https://www.cnki.com.cn/Article/CJFDTOTAL-XXGK201902026.htm

    FENG X R, ZHANG S L, HUANG C C. Influence of acupuncture combined butylphthalide soft capsule on cognitive function and MRI imaging in patients with vascular dementia[J]. Chinese Journal of Cardiovascular Rehabilitation Medicine, 2019, 28(2): 233-237. https://www.cnki.com.cn/Article/CJFDTOTAL-XXGK201902026.htm
    [27]
    王渊, 刘智斌, 刘龙, 等. 雷射针刺治疗血管性痴呆的临床疗效及对血清抗凋亡因子的影响[J]. 四川中医, 2019, 37(2): 187-190. https://www.cnki.com.cn/Article/CJFDTOTAL-SCZY201902066.htm

    WANG Y, LIU Z B, LIU L, et al. Clinical Observation of Laser Acupuncture for Treating Vascular Dementia and Its Influence on Serum Livin[J]. Journal of Sichuan of Traditional Chinese Medicine, 2019, 37(2): 187-190. https://www.cnki.com.cn/Article/CJFDTOTAL-SCZY201902066.htm
    [28]
    MAES M E, GROSSER J A, FEHRMAN R L, et al. Completion of BAX recruitment correlates with mitochondrial fission during apoptosis[J]. Sci Rep, 2019, 9(1): 16565. DOI: 10.1038/s41598-019-53049-w.
    [29]
    靳田田, 李莹, 陈逸飞, 等. 补肾健脾开心方对D-gal诱导的亚急性衰老大鼠脑皮质炎症及凋亡相关蛋白Bcl-2、Bax的影响[J]. 时珍国医国药, 2022, 33(8): 1847-1849. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY202208016.htm

    JIN T T, LI Y, CHEN Y F, et al. Effects of BushenJianpi Kaixinfang on cortical inflammation and apoptosis-related proteins Bcl-2 and Bax induced by D-gal in subacute aging rats[J]. Lishizhen Medicine and Materia Medica Research, 2022, 33(8): 1847-1849. https://www.cnki.com.cn/Article/CJFDTOTAL-SZGY202208016.htm
    [30]
    陈英华, 郝志平. 针刺四神聪、风池穴对血管性痴呆大鼠海马区Bcl-2、bax表达影响[J]. 辽宁中医药大学学报, 2019, 21(1): 24-26. https://www.cnki.com.cn/Article/CJFDTOTAL-LZXB201901008.htm

    CHEN Y H, HAO Z P. Effects of Acupuncture at Sishencong and Fengchi on Bcl-2 and Bax Expression in Hippocampal Area of Rats with Vascular Dementia[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2019, 21(1): 24-26. https://www.cnki.com.cn/Article/CJFDTOTAL-LZXB201901008.htm
    [31]
    ALOTHAID H, ALDUGHAIM M S K, ALAMRI S S, et al. Role of calcineurin biosignaling in cell secretion and the possible regulatory mechanisms[J]. Saudi J Biol Sci, 2021, 28(1): 116-124.
    [32]
    葛亮, 曹慧玲, 张洁, 等. 川芎嗪对大鼠脑缺血再灌注损伤后氧化应激、Ca2+-ATP酶活性及炎症因子的影响[J]. 国际检验医学杂志, 2021, 42(5): 517-520. https://www.cnki.com.cn/Article/CJFDTOTAL-GWSQ202105003.htm

    GE L, CAO H L, ZHANG J, et al. Effect of tetramethylpyrazine on oxidative stress, Ca2+-ATP activity and inflammatory factors after cerebral ischemia/reperfusion injury in rats[J]. International Journal of Laboratory Medicine, 2021, 42(5): 517-520 https://www.cnki.com.cn/Article/CJFDTOTAL-GWSQ202105003.htm
    [33]
    颜丽巧, 易伊人, 陈茂, 等. 基于信号转导通路探讨针灸治疗血管性痴呆的作用机制[J]. 中医药导报, 2022, 28(10): 100-104. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZB202210023.htm

    YAN L Q, YI Y R, CHEN M, et al. Study on the mechanism of acupuncture in treating vascular dementia based on signal transduction pathway[J]. Guiding Journal of Traditional Chinese Medicine and Pharmacy, 2022, 28(10): 100-104. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZB202210023.htm
    [34]
    王振垚. 针刺颈夹脊穴对卒中后血管性痴呆患者血清BDNF、VEGF、MMP-9水平的影响[J]. 上海针灸杂志, 2019, 38(8): 842-847. https://www.cnki.com.cn/Article/CJFDTOTAL-SHZJ201908007.htm

    WANG Z Y. Effect of Acupuncture at Jiaji(EX-B2) Points on the Levels of Serum BDNF, VEGF and MMP-9 in Patients with Post-stroke Vascular Dementia[J]. Shanghai Journal of Acupuncture and Moxibustion, 2019, 38(8): 842-847. https://www.cnki.com.cn/Article/CJFDTOTAL-SHZJ201908007.htm
    [35]
    杨海波, 徐朝辉, 甄玉婷, 等. 针刺通里和大钟穴为主治疗血管性痴呆的临床研究[J]. 上海针灸杂志, 2022, 41(12): 1166-1170. https://www.cnki.com.cn/Article/CJFDTOTAL-SHZJ202212003.htm

    YANG H B, XU Z H, ZHEN Y T, et al. Clinical Study on the Treatment of Vascular Dementia by Acupuncture Mainly at Tongli(HT5)and Dazhong(KI4)Acupoints[J]. Shanghai Journal of Acupuncture and Moxibustion, 2022, 41(12): 1166-1170. https://www.cnki.com.cn/Article/CJFDTOTAL-SHZJ202212003.htm
    [36]
    曹娟, 王红怡, 王丽欣, 等. 电针对缺氧缺血性脑损伤大鼠海马神经元自噬及IGF-1/PI3K/Akt通路的影响[J]. 实用临床医药杂志, 2022, 26(14): 38-45. https://www.cnki.com.cn/Article/CJFDTOTAL-XYZL202214008.htm

    CAO J, WANG H Y, WANG L X, et al. Effects of electricity on autophagy and IGF-1/PI3K/Akt pathway of hippocampal neurons in rats with hypoxic-ischemic brain injury[J]. Journal of Practical Clinical Medicine, 2022, 26(14): 38-45. https://www.cnki.com.cn/Article/CJFDTOTAL-XYZL202214008.htm
    [37]
    邓畅, 邹莹洁, 张泓, 等. 电针对血管性痴呆大鼠血脑屏障及海马促炎细胞因子的影响[J]. 针刺研究, 2022, 47(10): 885-890. https://www.cnki.com.cn/Article/CJFDTOTAL-XCYJ202210006.htm

    DENG C, ZOU Y J, ZHANG H, et al. Effects of electroacupuncture on the blood-brain-barrier and proinflammatory cytokine IL-1β and IL-18 in the hippocampus of rats with vascular dementia[J]. Acupuncture Research, 2022, 47(10): 885-890. https://www.cnki.com.cn/Article/CJFDTOTAL-XCYJ202210006.htm
    [38]
    林雨芳. 电针后海穴对血管性痴呆大鼠海马区IGF-1蛋白表达的影响[J]. 中外医疗, 2018, 37(9): 30-33. https://www.cnki.com.cn/Article/CJFDTOTAL-HZZZ201809010.htm

    LIN Y F. Effect of Sea Cave after the Electroacupuncture on the Expression of IGF-1 Protein in Hippocampal Region of the Vascular Dementia Rats[J]. China & Foreign Medical Treatment, 2018, 37(9): 30-33. https://www.cnki.com.cn/Article/CJFDTOTAL-HZZZ201809010.htm
    [39]
    陈少萍, 梁超, 张燕珍, 等. 电针"智三针"对血管性痴呆患者疗效、认知功能、神经物质代谢影响研究[J]. 四川中医, 2022, 40(8): 173-176. https://www.cnki.com.cn/Article/CJFDTOTAL-SCZY202208053.htm

    CHEN S P, LIANG C, ZHANG Y Z, et al. Study on effect, cognitive function and neurometabolic effect of electroacupuncture "Zhi SAN acupuncture" on vascular dementia patients[J]. Journal of Sichuan of Traditional Chinese Medicine, 2022, 40(8): 173-176. https://www.cnki.com.cn/Article/CJFDTOTAL-SCZY202208053.htm
    [40]
    叶海森, 武凯歌, 张湘斌, 等. 醒脑开窍针刺法治疗血管性痴呆患者的疗效[J]. 世界中医药, 2020, 15(7): 1071-1074. https://www.cnki.com.cn/Article/CJFDTOTAL-SJZA202007028.htm

    YE H S, WU K G, ZHANG X B, et al. Effects in Patients with Vascular Dementia Using Acupuncture Method of Inducing Resuscitation[J]. World Chinese Medicine, 2020, 15(7): 1071-1074. https://www.cnki.com.cn/Article/CJFDTOTAL-SJZA202007028.htm
    [41]
    熊金花, 蔡伟彬, 秦敏. 岭南飞针疗法之头皮针治疗血管性痴呆40例临床疗效观察[J]. 中医药导报, 2020, 26(16): 90-92, 96. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZB202016022.htm

    XIONG J H, CAI W B, QIN M. Clinical Observation on Scalp Acupuncture of Lingnan Flying Needle for Vascular Dementia[J]. Guiding Journal of Traditional Chinese Medicine and Pharmacy, 2020, 26(16): 90-92, 96. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZB202016022.htm
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