Efficacy and safety of lupatadine combined with LED-LLLT yellow light in the treatment of facial hormone-dependent dermatitis

YAN Yan; SUN Wei; ZHAO Lian; YANG Chunsheng

doi:10.16766/j.cnki.issn.1674-4152.003157

Volume 21 Issue 9

Sep. 2023

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Article Navigation > Chinese Journal of General Practice > 2023 > 21(9): 1508-1511

YAN Yan, SUN Wei, ZHAO Lian, YANG Chunsheng. Efficacy and safety of lupatadine combined with LED-LLLT yellow light in the treatment of facial hormone-dependent dermatitis[J]. Chinese Journal of General Practice, 2023, 21(9): 1508-1511. doi: 10.16766/j.cnki.issn.1674-4152.003157

Citation:

YAN Yan, SUN Wei, ZHAO Lian, YANG Chunsheng. Efficacy and safety of lupatadine combined with LED-LLLT yellow light in the treatment of facial hormone-dependent dermatitis[J]. Chinese Journal of General Practice, 2023, 21(9): 1508-1511. doi: 10.16766/j.cnki.issn.1674-4152.003157

Citation:

YAN Yan, SUN Wei, ZHAO Lian, YANG Chunsheng. Efficacy and safety of lupatadine combined with LED-LLLT yellow light in the treatment of facial hormone-dependent dermatitis[J]. Chinese Journal of General Practice, 2023, 21(9): 1508-1511. doi: 10.16766/j.cnki.issn.1674-4152.003157

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Efficacy and safety of lupatadine combined with LED-LLLT yellow light in the treatment of facial hormone-dependent dermatitis

doi: 10.16766/j.cnki.issn.1674-4152.003157

YAN Yan^{1
,
,}
, SUN Wei¹
, ZHAO Lian¹
, YANG Chunsheng²

1.
Department of Dermatology, Huaibei Miners General Hospital, Huaibei, Anhui 235000, China

Funds:

81803151

Received Date: 2023-03-02
Available Online: 2023-10-19

Abstract

Abstract

Objective The treatment effect of facial hormone-dependent dermatitis is limited and the short-term recurrence rate is high. This study discussed the efficacy and safety of lupatadine combined with LED yellow light treatment in order to find an effective and safe treatment method. Methods A total of 96 patients with facial hormone-dependent dermatitis treated in Huaibei Miners General Hospital from October 2018 to September 2021 were selected as research objects and randomly divided into study group and control group, with 48 cases in each group. The control group was irradiated with LED-LLLT yellow light 15 min/time, once every other day, and the study group was combined with lupatadine tablets 10 mg once a day on the basis of yellow light therapy. The course of treatment was 4 weeks. After treatment, the total effective rate, improvement of subjective and objective symptoms, quality of life of skin diseases, adverse reactions and recurrence rate 1 month later were compared between the two groups. Results After treatment, the total effective rate of the study group was 87.23%(41/47), which was significantly higher than that of the control group (31/46, 67.39%, P=0.022). The total score of subjective and objective symptoms in the study group [7.0(4.0, 10.0) points] was lower than that in the control group [9.5(6.0, 14.0) points, Z=-2.751, P=0.006]. The total DLQI score of study group [(8.00±1.96) points] was lower than that of control group [(9.89±2.18) points, P < 0.001]. The total incidence of adverse reactions in the two groups were 10.64% (5/47) and 8.70%(4/46), respectively, with no significant difference (P=0.751). The recurrence rate of the study group was 7.32%(3/41), which was lower than that of the control group (25.81%, 8/31) one month after treatment (P=0.031). Conclusion Lupatadine combined with LED yellow light treatment can improve the therapeutic effect, reduce the short-term recurrence rate, and has good safety.
- Hormone-dependent dermatitis,
- Lupatadine,
- LED yellow light,
- Clinical effect,
- Safety

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References(20)

References

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Efficacy and safety of lupatadine combined with LED-LLLT yellow light in the treatment of facial hormone-dependent dermatitis

doi: 10.16766/j.cnki.issn.1674-4152.003157