Volume 21 Issue 10
Oct.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(10): 1651-1653
ZHANG Chengzhong, HUANG Chen, LIU Ja, JI Jie, LU Yan. Clinical and laboratory characteristics of chronic spontaneous urticaria with connective tissue diseases[J]. Chinese Journal of General Practice, 2023, 21(10): 1651-1653. doi: 10.16766/j.cnki.issn.1674-4152.003191
Citation: ZHANG Chengzhong, HUANG Chen, LIU Ja, JI Jie, LU Yan. Clinical and laboratory characteristics of chronic spontaneous urticaria with connective tissue diseases[J]. Chinese Journal of General Practice, 2023, 21(10): 1651-1653. doi: 10.16766/j.cnki.issn.1674-4152.003191
shu

Clinical and laboratory characteristics of chronic spontaneous urticaria with connective tissue diseases

doi: 10.16766/j.cnki.issn.1674-4152.003191

  • Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China

Funds:

 82203918

 BK20201082

  • Received Date: 2023-05-04
    Available Online: 2023-11-23
    Abstract
  •   Objective  To retrospectively evaluate clinical and laboratory characteristics of chronic spontaneous urticaria (CSU) accompanied by connective tissue diseases (CTDs).  Methods  A total of 400 patients with CSU who were admitted to the Department of Dermatology of the First Affiliated Hospital of Nanjing Medical University from October 2020 to December 2022 were selected. Clinical and laboratory characteristics of CSU in patients with and without CTD were analyzed.  Results  The male and female proportions of patients with CSU associated with positive Anti-TPO and ANA were 13.8% (22/160), 18.1% (29/160) and 33.3% (80/240), 37.1% (89/240), respectively. Among them, there are 40 female cases and 6 male cases of patients with CTD, mainly including rheumatoid arthritis, Sjogren' s syndrome, and systemic lupus erythematosus. The proportion of serum specific IgE antibody, Anti-TPO and Anti-Tg increased in female patients was significantly higher than that in male patients (all P < 0.05), and the proportion of abnormal levels of IgG, IgM, IgA, complement C3 in five immunological items was significantly higher than that in male patients (all P < 0.05). The proportion of positive ANA in female patients was also significantly higher than that in male patients (P < 0.05). The proportion of serum specific IgE antibody, Anti-TPO, Anti-Tg, RF and ESR increased in patients with connective tissue disease was significantly higher than that in patients without connective tissue disease (all P < 0.05), and the antibody positive rate in patients with connective tissue disease was higher than that in patients without connective tissue disease, there were significant differences in the levels of ANA, Anti-dsDNA, Anti-Sm, Anti-SSA, Anti-SSB, Anti-Jo-1 and Anti-PM-Scl 100 (all P < 0.05).  Conclusion  The results suggest that CSU is associated with CTDs, especially in female patients. Any patient diagnosed with CSU should be questioned about rheumatic symptoms, and especially in female patients, chronic spontaneous urticaria should be routinely tested for associated antibodies.

     

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