Volume 21 Issue 10
Oct.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(10): 1657-1660
WU Yanyan, KE Xiquan, MA Zhenzeng, DENG Min, WANG Meng. Analysis of the efficacy of endoscopic submucosal dissection for early gastric cancer and precancerous lesions[J]. Chinese Journal of General Practice, 2023, 21(10): 1657-1660. doi: 10.16766/j.cnki.issn.1674-4152.003193
Citation: WU Yanyan, KE Xiquan, MA Zhenzeng, DENG Min, WANG Meng. Analysis of the efficacy of endoscopic submucosal dissection for early gastric cancer and precancerous lesions[J]. Chinese Journal of General Practice, 2023, 21(10): 1657-1660. doi: 10.16766/j.cnki.issn.1674-4152.003193
shu

Analysis of the efficacy of endoscopic submucosal dissection for early gastric cancer and precancerous lesions

doi: 10.16766/j.cnki.issn.1674-4152.003193

  • Department of Gastroenterology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 2022a05020022

  • Received Date: 2023-05-04
    Available Online: 2023-11-23
    Abstract
  •   Objective  To study the safety and efficacy of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) and precancerous lesions.  Methods  The clinical data of 110 patients with EGC and precancerous lesions treated with ESD in the Digestive Endoscope Center of the First Affiliated Hospital of Bengbu Medical College from January 1, 2019 to December 31, 2022 were analyzed retrospectively. The observation indexes included the characteristics of the focus, pathology, operative complications, postoperative recurrence and so on, and the difference of pathological results was compared before and after ESD. The data of sex, age, lesion diameter, focus location, intraoperative perforation and postoperative pathological results of patients with delayed hemorrhage after ESD and non-bleeding group were collected, and the risk factors of delayed hemorrhage after ESD were explored.  Results  In 110 patients treated with ESD, the overall resection rate was 100.0% (110/110), the complete resection rate was 95.5% (105/110), and the curative resection rate was 93.6% (103/110). Postoperative pathology: low-grade intraepithelial neoplasia was 54, high-grade intraepithelial neoplasia was 30, intramucosal carcinoma was 20 and submucosal carcinoma was 6. There was significant difference between preoperative and postoperative pathology (P < 0.05). Delayed bleeding occurred in 6 cases, all of which occurred within 24 hours after operation. Univariate analysis showed that the lesion diameter≥3 cm might be related to delayed bleeding after ESD. There were 3 cases of intraoperative perforation, and no delayed perforation occurred in all patients. Up to February 28, 2023, 110 patients were successfully followed up for 3 to 50 months, with a median follow-up period of 23 months. All patients had no recurrence.  Conclusion  ESD is a safe and effective surgical procedure for the treatment of EGC and precancerous lesions, but strict indications are required and accurate preoperative evaluation is particularly important.

     

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