Volume 21 Issue 10
Oct.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(10): 1669-1672
HU Chao, CHENG Xi, JIN Wangxun, YAO Hongqing, WANG Xinbao. Comparison of the efficacy of surgical resection and radiofrequency ablation after chemotherapy for resectable colorectal liver metastases[J]. Chinese Journal of General Practice, 2023, 21(10): 1669-1672. doi: 10.16766/j.cnki.issn.1674-4152.003196
Citation: HU Chao, CHENG Xi, JIN Wangxun, YAO Hongqing, WANG Xinbao. Comparison of the efficacy of surgical resection and radiofrequency ablation after chemotherapy for resectable colorectal liver metastases[J]. Chinese Journal of General Practice, 2023, 21(10): 1669-1672. doi: 10.16766/j.cnki.issn.1674-4152.003196
shu

Comparison of the efficacy of surgical resection and radiofrequency ablation after chemotherapy for resectable colorectal liver metastases

doi: 10.16766/j.cnki.issn.1674-4152.003196

  • Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China

Funds:

 2021KY598

  • Received Date: 2023-05-04
    Available Online: 2023-11-23
    Abstract
  •   Objective  Systemic chemotherapy followed by local treatment is recommended for patients with colorectal liver metastases (CRLMs). However, there is no consensus on the choice of local treatment for CRLMs after chemotherapy. The research aims to evaluate the efficacy of surgical resection and radiofrequency ablation (RFA) in these patients to provide some information for clinicians.  Methods  The clinical data of 63 patients with colorectal liver metastases who accepted chemotherapy and underwent local treatment (surgical resection or RFA) at Zhejiang Cancer hospital from January 1, 2017 to December 31, 2017 were retrospectively analyzed. All patients were divided into two groups according to the different methods of local treatment: hepatectomy group and RFA group. The 25 patients in hepatectomy group accepted hepatectomy and the 38 patients in RFA group accepted RFA. The efficacy of surgical resection and RFA in the treatment of colorectal liver metastases (CRLMs) was compared by analyzing local Recurrence-Free Survival time and Recurrence-Free Survival rates of 1 year, 2 years and 3 years.  Results  There was no significant difference in the number and maximum size of CRLMs between the hepatectomy and RFA groups. Patients were followed for 36 months. Local liver recurrences occurred in 16 patients in the hepatectomy group (64.0%) and 35 patients in the RFA group (92.1%). The median RFS time in the hepatectomy group (24.0 months, 95% CI: 6.0-42.0 months) was significant longer than the RFA group (4.0 months, 95% CI: 3.1-4.9 months, P < 0.05). The 1-year, 2-years and 3-years RFS rates were 64.0%, 52.0% and 36.0% in the hepatectomy group and 21.1%, 10.5%, 10.5% in the RFA group. There were significant differences between the two groups (all P < 0.05).  Conclusion  For some patients with resectable CRLMs who have accepted chemotherapy, surgical resection may result in a lower rate of local recurrence and longer RFS.

     

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