Volume 21 Issue 10
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CAO Wei, LIU Liang, FANG Minjian, QIU Ruolan. Diagnostic value of CT combined with serum tumor marker in oral squamous cell carcinoma[J]. Chinese Journal of General Practice, 2023, 21(10): 1673-1675. doi: 10.16766/j.cnki.issn.1674-4152.003197
Citation: CAO Wei, LIU Liang, FANG Minjian, QIU Ruolan. Diagnostic value of CT combined with serum tumor marker in oral squamous cell carcinoma[J]. Chinese Journal of General Practice, 2023, 21(10): 1673-1675. doi: 10.16766/j.cnki.issn.1674-4152.003197
shu

Diagnostic value of CT combined with serum tumor marker in oral squamous cell carcinoma

doi: 10.16766/j.cnki.issn.1674-4152.003197

  • Department of Stomatology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 gxbjZD2021058

  • Received Date: 2023-03-11
    Available Online: 2023-11-23
    Abstract
  •   Objective  To explore the new diagnostic ideas of oral squamous cell carcinoma, and analyze the diagnostic efficacy and clinical significance of CT combined with tumor markers by observing the CT imaging features of patients and detecting the serum tumor markers of patients.  Methods  A total of 60 patients who underwent radical operation for oral squamous cell carcinoma in the First Affiliated Hospital of Bengbu Medical College from September 2020 to March 2022 and pathologically confirmed as squamous cell carcinoma were selected as the experimental group. In addition, 60 patients with oral and maxillofacial benign tumors were selected as the control group. Combined with preoperative CT images of patients, the differences in serum tumor markers between the two groups were compared. Postoperative pathological diagnosis was taken as the gold standard. Kappa test was used to compare the consistency between the two groups and pathological findings.  Results  Serum levels of tumor markers of squamous cell carcinoma associated antigen (SCC-Ag) and carcinoembryonic antigen (CEA) in experimental group were significantly higher than those in control group (all P < 0.05). CT combined with serum tumor marker detection showed high consistency with pathological results (Kappa=0.800, P < 0.001), and its diagnostic efficacy was higher than that of CT alone. CT combined with serum tumor markers had a high diagnostic value (AUC=0.900), serum tumor markers alone had a high diagnostic value (AUC=0.925), and CT alone had a medium diagnostic value (AUC=0.867). Tumor marker testing has the highest diagnostic efficacy, and the combination of the two has higher diagnostic efficacy than CT alone.  Conclusion  Compared with traditional preoperative CT imaging, serum tumor marker detection has a higher diagnostic accuracy. Considering the importance of patients ' preoperative imaging, CT combined with serum tumor marker detection can be used when necessary. The combined application of the two methods can improve the screening of oral squamous cell carcinoma, and both methods have less harm to patients, so they can be widely used.

     

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