Volume 21 Issue 10
Oct.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(10): 1676-1678
YANG Xiaoming, ZHENG Xiang, WANG Chaochao. Correlation between gut microbiota metabolites and coronary heart disease combined with chronic heart failure and its predictive role in patient prognosis[J]. Chinese Journal of General Practice, 2023, 21(10): 1676-1678. doi: 10.16766/j.cnki.issn.1674-4152.003198
Citation: YANG Xiaoming, ZHENG Xiang, WANG Chaochao. Correlation between gut microbiota metabolites and coronary heart disease combined with chronic heart failure and its predictive role in patient prognosis[J]. Chinese Journal of General Practice, 2023, 21(10): 1676-1678. doi: 10.16766/j.cnki.issn.1674-4152.003198
shu

Correlation between gut microbiota metabolites and coronary heart disease combined with chronic heart failure and its predictive role in patient prognosis

doi: 10.16766/j.cnki.issn.1674-4152.003198
  • 1.

    Department of Cardiovascular Medicine, Wenzhou Integrated Traditional Chinese and Western Medicine Hospital, Wenzhou, Zhejiang 325000, China

Funds:

 2022KY1208

  • Received Date: 2023-06-21
    Available Online: 2023-11-23
    Abstract
  •   Objective  To explore of the correlation between intestinal microbiota metabolites trimethylamine oxide (TMAO) and phenylacetylglutamine (PAGln) and cardiac function indicators in patients with stable coronary heart disease (SCAD) and chronic heart failure (CHF), and analyze the clinical value of their combined use in predicting major adverse cardiovascular events (MACE) in patients with SCAD and CHF.  Methods  A total of 200 patients with SCAD combined with CHF and 200 patients with SCAD alone admitted to the Cardiovascular Department of Wenzhou Integrated Traditional Chinese and Western Medicine Hospital from April 2018 to April 2021 were selected as the study subjects. The correlation between the contents of TMAO and PAGln and cardiac function indexes in SCAD patients with CHF were analyzed. The diagnostic efficacy of TMAO combined with PAGln in predicting MACE were analyzed.  Results  The left ventricular end systolic diameter (LVESD), left ventricular end diastolic diameter (LVEDD), matrix metalloproteinase-9 (MMP-9), brain natriuretic peptide (BNP), TMAO, and PAGln values in patients with SCAD combined with CHF were significantly higher than those in simple SCAD patient, while left ventricular ejection fraction (LVEF) and adiponectin (APN) values were significantly lower than those in patients with simple SCAD (all P < 0.05). TMAO and PAGln in patients with SCAD combined with CHF were positively correlated with LVESD, LVEDD, MMP-9, and BNP detection values (all P < 0.05), while they were negatively correlated with LVEF and APN detection values (all P < 0.05). Serum TMAO and PAGln levels in SCAD patients with MACE combined with CHF were significantly higher than those in non-MACE patients (all P < 0.05). TMAO combined with PAGln predicted the area, sensitivity and specificity under the receiver operating characteristic of MACE in patients with SCAD and CHF (0.964, 91.20% and 93.70%), which were higher than those predicted by both alone.  Conclusion  The levels of intestinal microbiota metabolites TMAO and PAGln in SCAD combined with CHF patients show an increasing trend, and the combination of the two has high clinical value in predicting MACE in SCAD combined with CHF patients.

     

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