Volume 21 Issue 10
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MAO Fangchao, ZHU Ping. Effect of 0.01% atropine eye drops on myopia control and its influencing factors in myopic teenagers[J]. Chinese Journal of General Practice, 2023, 21(10): 1683-1685. doi: 10.16766/j.cnki.issn.1674-4152.003200
Citation: MAO Fangchao, ZHU Ping. Effect of 0.01% atropine eye drops on myopia control and its influencing factors in myopic teenagers[J]. Chinese Journal of General Practice, 2023, 21(10): 1683-1685. doi: 10.16766/j.cnki.issn.1674-4152.003200
shu

Effect of 0.01% atropine eye drops on myopia control and its influencing factors in myopic teenagers

doi: 10.16766/j.cnki.issn.1674-4152.003200

  • Department of Ophthalmology, Haining People's Hospital, Haining, Zhejiang 314400, China

Funds:

 2023XY182

 2021065

  • Received Date: 2023-04-25
    Available Online: 2023-11-23
    Abstract
  •   Objective  The incidence of myopia in teenagers is gradually increasing, and the M receptor is involved in the whole process of myopia development. Atropine is a typical M receptor blocker. Therefore, the effect of 0.01% atropine eye drops on myopia control in adolescents with myopia and its influencing factors are discussed.  Methods  A total of 98 myopic adolescents admitted to Haining People's Hospital from March to August 2021 were selected as the research objects, and all received 0.01% atropine treatment. The 82 patients were followed up for 1 year. According to the treatment effect, they were divided into an effective group (50 cases, annual increase of myopia < 0.25 D or decrease of myopia ≥50%) and an ineffective group (32 cases, annual increase of myopia ≥0.25 D). A multivariate logistic regression model was used to analyze the related factors affecting the treatment effect of 0.01% atropine, and a ROC curve was drawn to evaluate the predictive value.  Results  There were significant differences in age, baseline equivalent spherical mirror SE and naked eye visual acuity between the two groups (all P < 0.05). Multivariate logistic regression analysis showed that age (OR=1.395, 95% CI: 1.023-1.901), naked eye visual acuity (OR=2.134, 95% CI: 1.087-4.187), equivalent spheroscope SE (OR=0.349, 95% CI: 0.183-0.666) were the factors influencing the therapeutic effect of 0.01% atropine (all P < 0.05). The ROC curve showed that the AUCs of age, baseline equivalent spheroscope SE and naked eye visual acuity in predicting the effect of 0.01% atropine were 0.708 (95% CI: 0.597-0.803), 0.799(95% CI: 0.696-0.879) and 0.714 (95% CI: 0.603-0.808), respectively.  Conclusion  The effect of 0.01% atropine in the treatment of myopic adolescents is significant. Younger age, higher baseline spherical equivalent SE and lower naked eye visual acuity are more likely to benefit from 0.01% atropine.

     

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