Volume 21 Issue 10
Oct.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(10): 1698-1701
HUANG Xiangwei, WANG Hong, XU Xia, WU Dongjing, YANG Xiangchou. Early identification and correlation analysis of infectious mononucleosis and acute suppurative tonsillitis in children[J]. Chinese Journal of General Practice, 2023, 21(10): 1698-1701. doi: 10.16766/j.cnki.issn.1674-4152.003204
Citation: HUANG Xiangwei, WANG Hong, XU Xia, WU Dongjing, YANG Xiangchou. Early identification and correlation analysis of infectious mononucleosis and acute suppurative tonsillitis in children[J]. Chinese Journal of General Practice, 2023, 21(10): 1698-1701. doi: 10.16766/j.cnki.issn.1674-4152.003204
shu

Early identification and correlation analysis of infectious mononucleosis and acute suppurative tonsillitis in children

doi: 10.16766/j.cnki.issn.1674-4152.003204
  • 1.

    Department of Laboratory Medicine, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China

Funds:

 LGJ21H100001

  • Received Date: 2023-02-06
    Available Online: 2023-11-23
    Abstract
  •   Objective  To explore the early differential diagnosis and correlation between pediatric infectious mononucleosis (IM) and acute suppurative tonsillitis (AST), and to provide reference for clinical diagnosis.  Methods  A total of 130 children with IM (IM group) and 100 children with AST (control group) admitted between January 2021 and June 2022 were selected as study subjects. The clinical data and laboratory indicators of the two groups were analyzed and compared. The receiver operating characteristic curve (ROC curve) was used to analyze the predictive ability of multiple indicators for the early diagnosis of IM. Spearman correlation was used to analyze the correlation between laboratory indicators.  Results  In terms of clinical manifestations, body temperature < 39 ℃, eyelid edema, neck lymph node enlargement and tonsil secretions were significantly higher in IM group than in the control group, with statistical significance (all P < 0.05). At the early stage of infection, the levels of CRP, neutrophil lymphocyte ratio (NLR), monocyte lymphocyte ratio (MLR), CD4+/CD8+, prealbumin (PA), CRP/PA and C-reactive protein/albumin ratio (CAR) levels were lower in IM group than in the control group, with statistical significance (all P < 0.05). After IM treatment, the levels of CRP, WBC, MLR, CRP/PA and CAR were decreased, while the levels of NLR and PA were increased with statistical significance compared with before treatment (P < 0.05), while the level of ALB was not statistically significant. The ROC curve showed that the AUC of combined detection was 0.988, both higher than that of single detection. NLR was positively correlated with CRP and CAR (r=0.431, 0.433, all P < 0.05). CRP/PA was positively correlated with NLR (r=0.443, P < 0.05), and negatively correlated with PA (r=-0.340, P < 0.05).  Conclusion  Early identification of IM and AST is difficult and misdiagnosis is easy. Laboratory indicators such as CRP, NLR, MLR, CD4+/CD8+, PA, CRP/PA, CAR and clinical manifestations (body temperature < 39 ℃, eyelid edema, cervical lymph node enlargement, amygdala secretion) can be evaluated and compared. The combined application has great application value to improve the early diagnosis and efficacy evaluation of IM, and provides clinical assistance.

     

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