Volume 21 Issue 10
Oct.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(10): 1767-1769
CHEN Kelong, SONG Chengcheng, CHEN Ling. Clinical application of supplementing Qi and activating blood in patients with cognitive impairment due to cerebral small vessel disease[J]. Chinese Journal of General Practice, 2023, 21(10): 1767-1769. doi: 10.16766/j.cnki.issn.1674-4152.003220
Citation: CHEN Kelong, SONG Chengcheng, CHEN Ling. Clinical application of supplementing Qi and activating blood in patients with cognitive impairment due to cerebral small vessel disease[J]. Chinese Journal of General Practice, 2023, 21(10): 1767-1769. doi: 10.16766/j.cnki.issn.1674-4152.003220
shu

Clinical application of supplementing Qi and activating blood in patients with cognitive impairment due to cerebral small vessel disease

doi: 10.16766/j.cnki.issn.1674-4152.003220

  • Department of Neurology, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang 325000, China

Funds:

 2022ZB338

 Y20220219

  • Received Date: 2023-06-28
    Available Online: 2023-11-23
    Abstract
  •   Objective  The purpose of this study was to investigate the clinical effect of qi-supplementation and blood-activation therapy with Buyang Huanwu Decoction in the treatment of patients with cognitive impairment due to cerebral small vessel disease, focusing on the effects on cognitive function, attention, executive function and inflammatory factors.  Methods  A total of 60 patients with cerebral small vessel disease and cognitive impairment admitted to Wenzhou TCM Hospital of Zhejiang Chinese Medical University from February 2022 to May 2023 were selected. The random number table method was used in two groups. The control group (30 cases) was treated with donepezil tablets, and the observation group (30 cases) was treated with Buyang Huanwu decoction for qi-supplementation and blood-activation on the basis of the treatment scheme of the control group. The patients ' cognitive function, attention and executive function were assessed by using Montreal cognitive assessment scale (MoCA), the digit symbol substitution test (DSST) and the trail making test (TMT). Levels of inflammatory factors [blood homocysteine (Hcy), hypersensitive C-reactive protein (hs-CRP)] were compared between the two groups.  Results  Compared before treatment, the MoCA and DSST scores in both groups were significantly increased after treatment (all P < 0.05), and the MoCA and DSST scores in the observation group were significantly higher than those in the control group (all P < 0.05). Compared with before treatment, the TMT time in both groups decreased significantly after treatment (all P < 0.05), and the TMT time in the observation group [TMT-A: (71.10±10.44) s; TMT-B: (222.63±30.84) s] was significantly lower than that in the control group [TMT-A: (77.63±12.44) s; TMT-B: (241.53±38.03) s, all P < 0.05]. After treatment, the levels of Hcy and hs-CRP in both groups were significantly lower than those before treatment (all P < 0.05), and Hcy and hs-CRP in the observation group were significantly lower than those in the control group (all P < 0.05).  Conclusion  Supplemening Qi and activating blood circulation can significantly improve the cognitive function and executive function of patients with cognitive impairment due to cerebral small vessel disease, and reduce the level of inflammatory factors in patients.

     

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