Antimicrobial resistance of common pathogens and their special types in urinary tract infection

ZHENG Siqiang; LIU Lin; FAN Shendong; SUN Wenbo; CHEN Bin; HE Qiang

doi:10.16766/j.cnki.issn.1674-4152.003241

Volume 21 Issue 11

Nov. 2023

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ZHENG Siqiang, LIU Lin, FAN Shendong, SUN Wenbo, CHEN Bin, HE Qiang. Antimicrobial resistance of common pathogens and their special types in urinary tract infection[J]. Chinese Journal of General Practice, 2023, 21(11): 1852-1855. doi: 10.16766/j.cnki.issn.1674-4152.003241

Citation:

ZHENG Siqiang, LIU Lin, FAN Shendong, SUN Wenbo, CHEN Bin, HE Qiang. Antimicrobial resistance of common pathogens and their special types in urinary tract infection[J]. Chinese Journal of General Practice, 2023, 21(11): 1852-1855. doi: 10.16766/j.cnki.issn.1674-4152.003241

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Antimicrobial resistance of common pathogens and their special types in urinary tract infection

doi: 10.16766/j.cnki.issn.1674-4152.003241

ZHENG Siqiang^{1, 2}
, LIU Lin²
, FAN Shendong²
, SUN Wenbo²
, CHEN Bin³
, HE Qiang^{1, 4
,
,}

1.
Second Clinical Medical College, the Second Clinical Medical College of Zhejiang Chinese Medicine University, Hangzhou, Zhejiang 310053, China

Funds:

2022KY1172

Received Date: 2022-10-25
Available Online: 2024-01-13

Abstract

Abstract

Objective To investigate the antimicrobial resistance of common pathogenic bacteria and their special types in urine culture of urinary tract infection (UTI) patients, and to provide reference for clinical workers in the empirical treatment of urinary tract infection. Methods The urine culture results and drug resistance were collected from the information system database of Zhejiang Provincial People's Hospital from January 2020 to December 2021, and 3 770 UTI patients were eventually included. The isolated pathogens and their drug susceptibility results were statistically analyzed. Results A total of 4 284 non-duplicate strains were isolated in this study. There were 2 746 strains (64.10%) of Gram-negative bacteria, 875 strains (20.42%) of Gram-positive bacteria, 385 strains (8.99%) of fungi and 278 strains (6.49%) of mycoplasma. The top four isolates were Escherichia coli, Klebsiella pneumoniae, Enterococcus faecium and Enterococcus faecalis. Among them, the drug resistance rate of the bacteria producing extended-spectrum β-lactamases and carbapenem resistant bacteria was significantly higher than that of common pathogens. The resistance rate of the former to β-lactam and quinolone antibacterial drugs was significantly higher than that of common pathogens, and it maintained good antibacterial activity against antibiotics and carbapenems with enzyme inhibitors. The latter only showed good sensitivity to tigecycline and amikacin. Conclusion The most common pathogen in urinary tract infection is still gram-negative bacteria. Drug-resistant bacteria such as producing extended-spectrum β-lactamases and carbapenem resistant bacteria are more than before. Clinical initial use of antibacterial drugs can refer to the results of this study for empirical treatment, and antibacterial drugs can be changed according to the drug resistance of pathogenic bacteria after the results of urine culture are available.
- Urinary tract infection,
- Urine culture,
- Drug sensitivity analysis,
- Drug resistance rate

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References(17)

References

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Antimicrobial resistance of common pathogens and their special types in urinary tract infection

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