Volume 21 Issue 11
Nov.  2023
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(11): 1856-1859
HUANG Yue, WEI Xiaosong, JIANG Chao, WU Hanxia, WANG Tao, LI Zhijun. Expression levels of serum Krebs von den Lungen-6 and interleukin 33 in rheumatoid arthritis patients and their clinical significance[J]. Chinese Journal of General Practice, 2023, 21(11): 1856-1859. doi: 10.16766/j.cnki.issn.1674-4152.003242
Citation: HUANG Yue, WEI Xiaosong, JIANG Chao, WU Hanxia, WANG Tao, LI Zhijun. Expression levels of serum Krebs von den Lungen-6 and interleukin 33 in rheumatoid arthritis patients and their clinical significance[J]. Chinese Journal of General Practice, 2023, 21(11): 1856-1859. doi: 10.16766/j.cnki.issn.1674-4152.003242
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Expression levels of serum Krebs von den Lungen-6 and interleukin 33 in rheumatoid arthritis patients and their clinical significance

doi: 10.16766/j.cnki.issn.1674-4152.003242
  • 1.

    Department of Rheumatology and Immunology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 2020WR03013

  • Received Date: 2023-04-08
    Available Online: 2024-01-13
    Abstract
  •   Objective  To understand the expression levels of serum Krebs von den Lungen-6 (KL-6) and interleukin 33 (IL-33) in patients with rheumatoid arthritis (RA), and to investigate the diagnostic value of detecting serum KL-6 and IL-33 in RA-associated interstitial lung disease (RA-ILD).  Methods  A total of 88 patients diagnosed with RA who were admitted to the Rheumatology Department of the First Affiliated Hospital of Bengbu Medical College and the First Affiliated Hospital of Anhui Hospital of Science and Technology from May 2022 to February 2023 were selected. They were divided into general RA group (40 cases) and RA-ILD group (48 cases) according to the presence of interstitial lung disease (ILD) on lung CT. Serological indicators of RA, such as serum rheumatoidfactors (RF), erythrocytesedimentationrate (ESR) and anticyclic citrullinated peptide antibody (anti-CCP) were found in all patients. At the same time, the levels of serum KL-6 and IL-33 in the above patients were determined, the correlation between each index and ILD was analyzed, and the diagnostic efficiency of each index for RA-ILD was analyzed by receiver operating characteristic (ROC) curve.  Results  Serum KL-6 and IL-33 levels were significantly increased in RA-ILD group; serum KL-6 was positively correlated with ESR, CRP, and D-dimer, and serum IL-33 was positively correlated with IgG and globulin. After ROC analysis, the area under the curve (AUC) of each index for diagnosing RA-ILD was RF (0.678), ESR (0.667), CRP (0.716), D-dimer (0.702), IgA (0.666), KL-6 (0.773) and IL-33 (0.705). The AUC of combined detection of KL-6 and IL-33 in diagnosing RA-ILD was 0.816, both of which were superior to individual detection.  Conclusion  The combined detection of serum KL-6 and IL-33 in RA patients has a high reference value for the early diagnosis of RA-ILD and the assessment of disease severity.

     

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