Volume 21 Issue 11
Nov.  2023
Turn off MathJax
Article Contents
Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(11): 1872-1875
ZHENG Zhenhui, JIANG Qiaomin, ZHANG Zunjing. Evaluation of the association between disease perception and medication adherence in patients with drug-resistant pulmonary tuberculosis using the propensity score method[J]. Chinese Journal of General Practice, 2023, 21(11): 1872-1875. doi: 10.16766/j.cnki.issn.1674-4152.003246
Citation: ZHENG Zhenhui, JIANG Qiaomin, ZHANG Zunjing. Evaluation of the association between disease perception and medication adherence in patients with drug-resistant pulmonary tuberculosis using the propensity score method[J]. Chinese Journal of General Practice, 2023, 21(11): 1872-1875. doi: 10.16766/j.cnki.issn.1674-4152.003246
shu

Evaluation of the association between disease perception and medication adherence in patients with drug-resistant pulmonary tuberculosis using the propensity score method

doi: 10.16766/j.cnki.issn.1674-4152.003246

  • Tuberculosis Department, Lishui Hospital of Traditional Chinese Medicine, Lishui, Zhejiang 323000, China

Funds:

 2022ZB399

  • Received Date: 2023-03-31
    Available Online: 2024-01-13
    Abstract
  •   Objective  The issue of medication adherence in patients with multi drug-resistance tuberculosis (MDR-TB) has received much attention. This study used propensity score matching (PSM) to explore the relationship between disease perception and medication adherence.  Methods  From June 2019 to October 2022, 172 patients with MDR-TB admitted to the tuberculosis department of Lishui Hospital of Traditional Chinese Medicine, and were divided into a good compliance group (n=103) and a poor compliance group (n=69) according to the Morisky medication adherence scale (MMAS-8). The relevant data between groups and the scores of the brief illness perception questionnaire (BIPQ) were compared, and the factors influencing MDR-TB patients' medication adherence were analyzed logistically. The PSM method performs balanced 1∶1 matching between groups and compares data between groups after PSM matching. To analyze the correlation between MMAS-8 and BIPQ scores in MDR-TB patients before and after PSM matching.  Results  Before PSM matching, the proportion of the good compliance group with age < 60 years, disease duration < 2 years, education level of high school or above, family monthly income ≥6 000 yuan, and family supervised medication use was higher than that of the poor compliance group (all P < 0.05); the proportion of medical expenses, adverse drug reactions, and BIPQ score were lower in the poor compliance group (all P < 0.05). Age, disease course, level of education, family economic level, method of medical payment, adverse drug reactions and BIPQ scale scores were independent predictors of drug adherence in MDR-TB patients (all P < 0.05). After 48 pairs of PSM were successfully matched, the BIPQ of the good compliance group was still significantly lower than that of the poor compliance group [(35.17±5.78) points vs. (43.22±6.25) points, t=6.551, P < 0.05]. There was a moderate negative correlation between BIPQ and MMAS-8 scores in MDR-TB patients before and after PSM matching (r=-0.674, -0.574, all P < 0.05).  Conclusion  There are many factors influencing drug adherence in MDR-TB patients, and their level of disease perception is strongly negatively correlated with drug adherence.

     

    • FullText(HTML)
  • loading
    • References(17)
  • [1]
    ID G D, ID A K, TOLA H H, et al. Molecular characterization and drug resistance patterns of Mycobacterium tuberculosis complex in extrapulmonary tuberculosis patients in Addis Ababa, Ethiopia[J]. PLoS One, 2020, 15(12): 62-68.
    [2]
    余旭良, 胡昌弟, 金菊仙, 等. Xpert MTB/RIF联合GenoType MTBDRplus在衢州地区耐多药结核病快速诊断中的应用研究[J]. 中华全科医学, 2019, 17(8): 1375-1378. doi: 10.16766/j.cnki.issn.1674-4152.000948

    YU X L, HU C D, JIN J X, et al. The application of Xpert MTB/RIF combined with GenoType MTBDRplus in the rapid diagnosis of MDR-TB in Quzhou[J]. Chinese Journal of General Practice, 2019, 17(8): 1375-1378. doi: 10.16766/j.cnki.issn.1674-4152.000948
    [3]
    REICH E, TORRES C, HALAC E, et al. Compromise of self awareness and disease perception in multiple sclerosis[J]. J Neurol Sci, 2019, 40(5): 334-338.
    [4]
    卢群, 曾莉, 龚美芳, 等. 疾病感知在慢性病管理中的研究进展[J]. 护理研究, 2016, 30(4): 1288-1291.

    LU Q, ZENG L, GONG M F, et al. Research progress on disease perception in chronic disease management[J]. Nursing Research, 2016, 30(4): 1288-1291.
    [5]
    顾瑾, 张立群, 李亮, 等. WHO2014年版《耐药结核病规划管理指南伙伴手册》解读之二(概念和定义)[J]. 中国防痨杂志, 2015, 17(4): 411-412. doi: 10.3969/j.issn.1000-6621.2015.04.019

    GU J, ZHANG L Q, LI L, et al. Interpretation of WHO 2014 Version of Partner Handbook of Planning and Management Guidelines for Drug resistant tuberculosis (concept and definition)[J]. The Journal of The Chinese Antituberculosis Association, 2015, 17(4): 411-412. doi: 10.3969/j.issn.1000-6621.2015.04.019
    [6]
    MORISKY D E, ANG A, KROUSEL-WOOD M, et al. Predictive validity of a medication adherence measure in an outpatient setting[J]. NIH Public Access, 2008, 10(5): 348-354.
    [7]
    俞吉, 冉烁, 徐玲. Morisky用药依从性量表 8条目在老年慢性病患者用药评价中的应用[J]. 临床药物治疗杂志, 2020, 18(11): 63-66. doi: 10.3969/j.issn.1672-3384.2020.11.015

    YU J, RAN S, XU L. Application of 8-item Morisky medication adherence scale in medication evaluation of elderly patients with chronic diseases[J]. Clinical Medication Journal, 2020, 18(11): 63-66. doi: 10.3969/j.issn.1672-3384.2020.11.015
    [8]
    潘曼, 李海燕, 齐戈尧. 动脉粥样硬化患者介入术后服用抗血小板药物的依从性及其影响因素[J]. 介入放射学杂志, 2022, 31(9): 4917-4920.

    PAN M, LI H Y, QI G Y. The adherence of taking antiplatelet drugs in patients with atherosclerosis after receiving interventional therapy and analysis of its influencing factors[J]. Journal of Interventional Radiology, 2022, 31(9): 4917-4920.
    [9]
    SUBHASHIS B, JON P. The brief illness perception questionnaire[J]. Occup Med(Lond), 2016, 66(5): 419-420. doi: 10.1093/occmed/kqv203
    [10]
    崔怡然, 宇传华. 基于全球视角下的中国结核病负担现状与趋势分析[J]. 中华疾病控制杂志, 2020, 24(3): 258-263, 283.

    CUI Y R, YU C H. Analysis on the status and trend of TB burden in China from the global views[J]. Chinese Journal of Disease Control & Prevention, 2020, 24(3): 258-263, 283.
    [11]
    刘家起, 姜婧, 王亮, 等. 2008—2017年全国肺结核发病的时空分布特征分析[J]. 现代预防医学, 2020, 47(19): 3461-3464.

    LIU J Q, JIANG J, WANG L, et al. Spatial and temporal distribution of pulmonary tuberculosis in China, 2008-2017[J]. Modern Preventive Medicine, 2020, 47(19): 3461-3464.
    [12]
    初乃惠, 周文强. 耐药结核病的诊治进展[J]. 中华传染病杂志, 2021, 39(7): 398-403. doi: 10.3760/cma.j.cn311365-20210507-00163

    CHU N H, ZHOU W Q. Advances in the diagnosis and treatment of drug-resistant tuberculosis[J]. Chinese Journal of Infectious Diseases, 2021, 9(7): 398-403. doi: 10.3760/cma.j.cn311365-20210507-00163
    [13]
    刘庆苗, 涂修毅, 周秋娴. 慢性病患者疾病感知对健康促进行为及疾病控制状况的影响[J]. 广州医药, 2019, 50(5): 49-53.

    LIU Q M, TU X Y, ZHOU Q X. Impact of illness perception on health behavior and disease control in patients with chronic diseases[J]. Guangzhou Medical Journal, 2019, 50(5): 49-53.
    [14]
    MVLHAUSER S, BONHÔTE BÖRNER M, SANER H, et al. The impact of motivational interviewing on illness perception in patients with stable coronary artery disease. A randomised controlled study[J]. Pflege, 2018, 31(2): 75-85. doi: 10.1024/1012-5302/a000595
    [15]
    吴娱, 陈鑫, 谢云. 头颈部肿瘤放疗患者疾病感知与生活质量的相关性调查[J]. 海军医学杂志, 2022, 43(8): 847-851. doi: 10.3969/j.issn.1009-0754.2022.08.017

    WU Y, CHEN X, XIE Y. Correlation between disease perception and quality of life in the patients with head and neck tumor undergoing radiotherapy[J]. Journal of Navy Medicine, 2022, 43(8): 847-851. doi: 10.3969/j.issn.1009-0754.2022.08.017
    [16]
    陈依琳, 张美芬, 覃惠英, 等. 结直肠癌患者口服化疗药依从性与疾病感知相关性的纵向研究[J]. 中华护理杂志, 2017, 52(1): 8-13.

    CHEN Y L, ZHANG M F, QIN H Y, et al. Correlation between oral chemotherapy adherence and illness perception in colorectal cancer patients: a longitudinal study[J]. Chinese Journal Nursing, 2017, 52(1): 8-13.
    [17]
    席明霞, 屈婧, 肖美慧, 等. 耐药肺结核患者服药依从性影响因素的质性研究[J]. 华西医学, 2021, 36(1): 50-54.

    XI M X, QU J, XIAO M H, et al. Qualitative study on influencing factors of drug compliance in patients with drugresistant pulmonary tuberculosis[J]. West China Medical Journal, 2021, 36(1): 50-54.
    • Relative Articles
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(3)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (210) PDF downloads(18) Cited by()
    Proportional views
    Related

    Address：No. 287, Changhuai Road, Bengbu, Anhui Province, 233004, P.R.ChinaphoneNo：0552-3066635； 0552-3051890Email：zhqkyx@163.com

    Copyright © Chinese Journal of General Practice皖ICP备2020018345号-2

    Supported by: Beijing Renhe Information Technology Co., Ltd.    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return