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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(12): 2009-2013
BI Weipei, SHI Yan, WANG Lingling, ZHANG Hui, CUI Zhen. Clinical value of ultrasonography combined with shear wave elastography for the assessment of molecular subtypes of breast cancer[J]. Chinese Journal of General Practice, 2023, 21(12): 2009-2013. doi: 10.16766/j.cnki.issn.1674-4152.003278
Citation: BI Weipei, SHI Yan, WANG Lingling, ZHANG Hui, CUI Zhen. Clinical value of ultrasonography combined with shear wave elastography for the assessment of molecular subtypes of breast cancer[J]. Chinese Journal of General Practice, 2023, 21(12): 2009-2013. doi: 10.16766/j.cnki.issn.1674-4152.003278
shu

Clinical value of ultrasonography combined with shear wave elastography for the assessment of molecular subtypes of breast cancer

doi: 10.16766/j.cnki.issn.1674-4152.003278

  • Department of Ultrasound Medicine, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 2023AH051947

  • Received Date: 2023-08-03
    Available Online: 2024-01-29
    Abstract
  •   Objective  To investigate the relationship between qualitative and quantitative parameters of contrast ultrasound combined with shear wave elastography and different molecular staging of breast cancer.  Methods  Fifty-two patients with suspected malignant lesions detected by mammography and/or routine ultrasonography and confirmed as invasive breast cancer by the Department of Pathology of the First Affiliated Hospital of Bengbu Medical College from October 2022 to July 2023 were enrolled, and immunohistochemical results were collected, and were divided into three groups of breast cancer types based on the pathological results: luminal type (26 cases), HER-2 type (17 cases) and triple-negative (9 cases). Ultrasonographic and elastographic features of these patients were observed and time-intensity curves of breast cancer lesions were analyzed using ultrasonographic software, and ultrasonographic features of mass and quantitative parametric indicators of elastography were analyzed in relation to different molecular subtypes of breast cancer.  Results  There were significant differences in histological grading and lymph node metastasis between different breast cancer subtypes (P < 0.05), HER-2 positive breast cancer lesions were more likely to have a rapidly enhancing enhancement pattern(n=15, 88.2%, P < 0.05) as well as hyper-enhancing enhancement features(n=14, 82.4%, P < 0.05), and ultrasound elastography Emax values and the quantitative contrast parameter PI were significantly higher in patients with HER-2 subtype breast cancer than in luminal and triple-negative types [(170.32±53.35) kPa vs. (119.26±36.95) kPa vs. (155.80±73.59) kPa, P=0.006); (25.22±5.79) dB vs. (20.82±4.80) dB vs.(24.51±6.75) dB, P=0.030].  Conclusion  There is a correlation between ultrasound enhancement features and perfusion parameters combined with quantitative parameters of shear wave elastography and different molecular subtypes of breast cancer, so ultrasound analysis and quantitative parameters can be used as a more objective and accurate means of detection, which can provide a reference basis for clinical diagnosis of breast cancer, individualized treatment and prognostic analysis.

     

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