Volume 21 Issue 12
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Article Navigation >  Chinese Journal of General Practice  > 2023  >  21(12): 2009-2013
BI Weipei, SHI Yan, WANG Lingling, ZHANG Hui, CUI Zhen. Clinical value of ultrasonography combined with shear wave elastography for the assessment of molecular subtypes of breast cancer[J]. Chinese Journal of General Practice, 2023, 21(12): 2009-2013. doi: 10.16766/j.cnki.issn.1674-4152.003278
Citation: BI Weipei, SHI Yan, WANG Lingling, ZHANG Hui, CUI Zhen. Clinical value of ultrasonography combined with shear wave elastography for the assessment of molecular subtypes of breast cancer[J]. Chinese Journal of General Practice, 2023, 21(12): 2009-2013. doi: 10.16766/j.cnki.issn.1674-4152.003278
shu

Clinical value of ultrasonography combined with shear wave elastography for the assessment of molecular subtypes of breast cancer

doi: 10.16766/j.cnki.issn.1674-4152.003278

  • Department of Ultrasound Medicine, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

Funds:

 2023AH051947

  • Received Date: 2023-08-03
    Available Online: 2024-01-29
    Abstract
  •   Objective  To investigate the relationship between qualitative and quantitative parameters of contrast ultrasound combined with shear wave elastography and different molecular staging of breast cancer.  Methods  Fifty-two patients with suspected malignant lesions detected by mammography and/or routine ultrasonography and confirmed as invasive breast cancer by the Department of Pathology of the First Affiliated Hospital of Bengbu Medical College from October 2022 to July 2023 were enrolled, and immunohistochemical results were collected, and were divided into three groups of breast cancer types based on the pathological results: luminal type (26 cases), HER-2 type (17 cases) and triple-negative (9 cases). Ultrasonographic and elastographic features of these patients were observed and time-intensity curves of breast cancer lesions were analyzed using ultrasonographic software, and ultrasonographic features of mass and quantitative parametric indicators of elastography were analyzed in relation to different molecular subtypes of breast cancer.  Results  There were significant differences in histological grading and lymph node metastasis between different breast cancer subtypes (P < 0.05), HER-2 positive breast cancer lesions were more likely to have a rapidly enhancing enhancement pattern(n=15, 88.2%, P < 0.05) as well as hyper-enhancing enhancement features(n=14, 82.4%, P < 0.05), and ultrasound elastography Emax values and the quantitative contrast parameter PI were significantly higher in patients with HER-2 subtype breast cancer than in luminal and triple-negative types [(170.32±53.35) kPa vs. (119.26±36.95) kPa vs. (155.80±73.59) kPa, P=0.006); (25.22±5.79) dB vs. (20.82±4.80) dB vs.(24.51±6.75) dB, P=0.030].  Conclusion  There is a correlation between ultrasound enhancement features and perfusion parameters combined with quantitative parameters of shear wave elastography and different molecular subtypes of breast cancer, so ultrasound analysis and quantitative parameters can be used as a more objective and accurate means of detection, which can provide a reference basis for clinical diagnosis of breast cancer, individualized treatment and prognostic analysis.

     

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    • References(28)
  • [1]
    XIA C, DONG X, LI H, et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants[J]. Chin Med J (Engl), 2022, 135(5): 584-590. doi: 10.1097/CM9.0000000000002108
    [2]
    YAN C, LUO Z, LIN Z, et al. Shear wave elastography-assisted ultrasound breast image analysis and identification of abnormal data[J]. J Healthc Eng, 2022, 2022: 5499354. DOI: 10.1155/2022/5499354.
    [3]
    BURGUIN A, DIORIO C, DUROCHER F. Breast cancer treatments: updates and new challenges[J]. J Pers Med, 2021, 11(8): 808. doi: 10.3390/jpm11080808
    [4]
    任锋, 门永忠, 姚旗. 乳腺癌超声特征与病理、分子生物学指标的相关性研究[J]. 实用癌症杂志, 2020, 35(8): 1355-1358, 1372. doi: 10.3969/j.issn.1001-5930.2020.08.035

    REN F, MEN Y Z, YAO Q. Study on the correlation between ultrasonic characteristics and pathological and molecular biological indexes of breast cance[J]. The Practical Journal of Cancer, 2020, 35(8): 1355-1358, 1372. doi: 10.3969/j.issn.1001-5930.2020.08.035
    [5]
    CAI S, YAO M, CAI D, et al. Association between digital breast tomosynthesis and molecular subtypes of breast cancer[J]. Oncol Lett, 2019, 17(3): 2669-2676.
    [6]
    MURPHY B L, DAY C N, HOSKIN T L, et al. Adolescents and young adults with breast cancer have more aggressive disease and treatment than patients in their forties[J]. Ann Surg Oncol, 2019, 26(12): 3920-3930. doi: 10.1245/s10434-019-07653-9
    [7]
    WU T, LI J, WANG D, et al. Identification of a correlation between the sonographic appearance and molecular subtype of invasive breast cancer: a review of 311 cases[J]. Clin Imaging, 2019, 53: 179-185. doi: 10.1016/j.clinimag.2018.10.020
    [8]
    YUAN C, JIN F, GUO X, et al. Correlation analysis of breast cancer DWI combined with DCE-MRI imaging features with molecular subtypes and prognostic factors[J]. J Med Syst, 2019, 43(4): 1-10.
    [9]
    GUMOWSKA M, MACZEWSKA J, PROSTKO P, et al. Is there a correlation between multiparametric assessment in ultrasound and intrinsic subtype of breast cancer?[J]. J Clin Med, 2021, 10(22): 5394. doi: 10.3390/jcm10225394
    [10]
    陈雨薇, 李慧, 王才善. 超声弹性成像与超声造影对乳腺癌的诊断效能及其与免疫组织化学指标的相关性[J]. 临床与病理杂志, 2022, 42(10): 2420-2426. doi: 10.3978/j.issn.2095-6959.2022.10.013

    CHEN Y W, LI H, WANG C S. Diagnostic efficacy of ultrasonic elastography and contrast-enhanced ultrasound in breast cancer and their correlation with immunohistochemical markers[J]. Journal of Clinical and Pathological Research, 2022, 42(10): 2420-2426. doi: 10.3978/j.issn.2095-6959.2022.10.013
    [11]
    BURGUIN A, DIORIO C, DUROCHER F. Breast cancer treatments: updates and new challenges[J]. J Pers Med, 2021, 11(8): 808. doi: 10.3390/jpm11080808
    [12]
    CHEN F, HAN H, NING G, et al. Immunohistochemical index prediction of breast cancer by using hybrid ultrasound data[J]. IEEE Trans Biomed Eng, 2023, 70(4): 1401-1412. doi: 10.1109/TBME.2022.3217264
    [13]
    中国抗癌协会乳腺癌专业委员会. 中国抗癌协会乳腺癌诊治指南与规范(2021年版)[J]. 中国癌症杂志, 2021, 31(10): 954-1040.

    Breast Cancer Specialised Committee of the Chinese Anti-Cancer Association. Breast cancer diagnosis and treatment guidelines of the Chinese Anti-Cancer Association (2021 Edition)[J]. China Oncology, 2021, 31(10): 954-1040.
    [14]
    LIANG X, LI Z, ZHANG L, et al. Application of contrast-enhanced ultrasound in the differential diagnosis of different molecular subtypes of breast cancer[J]. Ultrason Imaging, 2020, 42(6): 261-270. doi: 10.1177/0161734620959780
    [15]
    KURT S A, KAYADIBI Y, SARACOGLU M S, et al. Prediction of molecular subtypes using superb microvascular imaging and shear wave elastography in invasive breast carcinomas[J]. Acad Radiol, 2023, 30(1): 14-21. doi: 10.1016/j.acra.2022.04.017
    [16]
    PEKER A, BALCI P, BASARA AKIN I, et al. Shear-Wave Elastography-guided core needle biopsy for the determination of breast cancer molecular subtype[J]. J Ultrasound Med, 2020, 40(6): 1183-1192.
    [17]
    MA M, LIU R, WEN C, et al. Predicting the molecular subtype of breast cancer and identifying interpretable imaging features using machine learning algorithms[J]. Eur Radiol, 2022, 32(3): 1652-1662. doi: 10.1007/s00330-021-08271-4
    [18]
    FERRE R, ELST J, SENTHILNATHAN S, et al. Machine learning analysis of breast ultrasound to classify triple negative and HER2+ breast cancer subtypes[J]. Breast Dis, 2023, 42(1): 59-66. doi: 10.3233/BD-220018
    [19]
    MAKAL G B, GÜVENĢ I. The role of shear wave elastography in differentiating idiopathic granulomatous mastitis from breast cancer[J]. Acad Radiol, 2021, 28(3): 339-344. doi: 10.1016/j.acra.2020.02.008
    [20]
    TEKCAN SANLI D E, YILDIRIM D, KANDEMIRLI S G, et al. Evaluation of multiparametric shear wave elastography indices in malignant and benign breast lesions[J]. Acad Radiol, 2022, 29(Suppl 1): S50-s61.
    [21]
    倪娟娟, 孙医学, 石彦, 等. 超声造影联合定量分析参数对炎症性肠病活动性诊断及治疗的临床指导价值[J]. 中华全科医学, 2023, 21(4): 655-658. doi: 10.16766/j.cnki.issn.1674-4152.002953

    NI J J, SUN Y X, SHI Y, et al. Contrast-enhanced ultrasound combined quantitative analysis of the parameters of clinical guidance value in the diagnosis and treatment of inflammatory bowel disease activity[J]. Chinese Journal of General Practice, 2023, 21(4): 655-658. doi: 10.16766/j.cnki.issn.1674-4152.002953
    [22]
    ZHANG H, GUO L, WANG D, et al. Multi-source transfer learning via multi-kernel support vector machine plus for B-mode ultrasound-based computer-aided diagnosis of liver cancers[J]. IEEE J Biomed Health Inform, 2021, 25(10): 3874-3875. doi: 10.1109/JBHI.2021.3073812
    [23]
    李玲玲, 苏荃利, 林菲菲, 等. 超声造影术前评价浸润性乳腺癌组织学分级的临床价值[J]. 中国超声医学杂志, 2022, 38(12): 1350-1354. doi: 10.3969/j.issn.1002-0101.2022.12.011

    LI L L, SU Q L, LIN F F, et al. Value of contrast-enhanced ultrasound in the preoperative evaluation of histological grade of invasive breast cancerr[J]. Chinese Journal of Ultrasound in Medicine, 2022, 38(12): 1350-1354. doi: 10.3969/j.issn.1002-0101.2022.12.011
    [24]
    赵青, 杨晓婧, 纪甜甜, 等. 超声助力式弹性成像和剪切波弹性成像及超声造影特征与乳腺癌分子生物学指标的相关性[J]. 中华实用诊断与治疗杂志, 2020, 34(8): 768-772.

    ZHAO Q, YANG X J, JI T T, et al. Correlations of ultrasound-assisted elasticity imaging, shear-wave elastography imaging and contrast-enhanced ultrasound features with molecular biological indexes of breast cancer[J]. Journal of Chinese Practical Diagnosis and Therapy, 2020, 34(8): 768-772.
    [25]
    ZHENG X, HUANG Y, LIU Y, et al. Shear-wave elastography of the breast: added value of a quality map in diagnosis and prediction of the biological characteristics of breast cancer[J]. Korean J Radiol, 2020, 21(2): 172-180. doi: 10.3348/kjr.2019.0453
    [26]
    PARK H J, KIM S M, YUN B, et al. Comparison of one- and two-region of interest strain elastography measurements in the differential diagnosis of breast masses[J]. Korean J Radiol, 2020, 21(4): 431-441. doi: 10.3348/kjr.2019.0479
    [27]
    方征兵, 鄢曹鑫. 超声造影及剪切波弹性成像与乳腺癌生物学预后因子的相关性分析[J]. 中国现代医生, 2023, 61(17): 1-5.

    FANG Z B, YAN C X. Correlation analysis of contrast-enhanced ultrasound and shear wave elastography with biological prognostic factors in breast cancer[J]. China Modern Doctor, 2023, 61(17): 1-5.
    [28]
    WEN B, KONG W, ZHANG Y, et al. Association between contrast-enhanced ultrasound characteristics and molecular subtypes of breast cancer[J]. J Ultrasound Med, 2022, 41(8): 2019-2031. doi: 10.1002/jum.15886
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